Advances in electro-microbial synergistic systems for value-added conversion of carbon dioxide

HAN Lin; GUO Yuman; LI Yan; CAO Hengheng; LI Jiajing; YANG Minghao; WANG Mengmeng; LI Jinping; LV Yongqin

doi:10.12211/2096-8280.2025-070

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Advances in electro-microbial synergistic systems for value-added conversion of carbon dioxide

更新时间：2025-10-10

- Advances in electro-microbial synergistic systems for value-added conversion of carbon dioxide
- Synthetic Biology Journal Pages: 1-30(2025)
- 作者机构：
  
  1.有机无机复合材料全国重点实验室，北京软物质科学与工程高精尖创新中心，北京化工大学，北京 100029
  2.国家能源生物炼制研发中心，教育部生物能源国际合作联合实验室，绿色化学品生物制造北京市重点实验室，生命科学与技术学院，北京化工大学，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2025-070
  CLC： Q819;O646
- Received：01 July 2025，
  
  Revised：2025-10-01，
  
  Online First：10 October 2025，
- 稿件说明：
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韩林，郭禹曼，李燕，曹珩珩，李嘉婧，杨明浩，汪萌萌，李晋萍，吕永琴. 电-微生物协同系统用于CO₂高值转化的研究进展［J］. 合成生物学， 2025， 6. DOI： 10.12211/2096-8280.2025-070

HAN Lin， GUO Yuman， LI Yan， CAO Hengheng， LI Jiajing， YANG Minghao， WANG Mengmeng， LI Jinping， LV Yongqin. Advances in electro-microbial synergistic systems for value-added conversion of carbon dioxide［J］. Synthetic Biology Journal， 2025， 6. DOI： 10.12211/2096-8280.2025-070
韩林，郭禹曼，李燕，曹珩珩，李嘉婧，杨明浩，汪萌萌，李晋萍，吕永琴. 电-微生物协同系统用于CO₂高值转化的研究进展［J］. 合成生物学， 2025， 6. DOI： 10.12211/2096-8280.2025-070 DOI：

HAN Lin， GUO Yuman， LI Yan， CAO Hengheng， LI Jiajing， YANG Minghao， WANG Mengmeng， LI Jinping， LV Yongqin. Advances in electro-microbial synergistic systems for value-added conversion of carbon dioxide［J］. Synthetic Biology Journal， 2025， 6. DOI： 10.12211/2096-8280.2025-070 DOI：

摘要

随着全球气候变化问题的日益加剧，开发高效、可持续的CO

转化技术已成为国际研究的前沿课题。特别是将CO

升级转化为具有高附加值的长链碳氢化合物（C

及以上）不仅有助于缓解温室效应，还为实现碳中和和构建循环经济体系提供了新路径。在众多技术路线中，电催化与生物催化因其温和的反应条件、良好的可控性和可模块化集成特性，展现出广阔的发展前景。然而，两者在独立应用中分别存在产物选择性差、固碳效率低或系统稳定性不足等瓶颈问题。近年来，电催化与微生物催化的协同耦合策略逐渐成为研究热点。该策略利用电能为微生物固碳过程提供能量和还原力，或通过电催化将CO

还原为C

中间产物（如CO、甲酸、乙酸等），进一步作为碳源被特定微生物利用，通过代谢途径高选择性合成丁醇、己酸、烯烃等多碳产物，实现对CO

的深度转化和资源化利用。根据电化学系统与生物系统在时间、空间及能量耦合方式的不同，该类系统可划分为电-菌原位耦合系统与电-菌异位耦合系统两大类。本文系统梳理了当前电-微生物细胞协同固碳转化合成化学品领域的研究进展，重点分析了不同耦合模式在产物分布调控、电子传递机制、界面构建策略及系统稳定性等方面的技术关键与科学挑战。进一步结合合成生物学、材料科学与反应工程的交叉融合趋势，提出了未来该领域在精准调控、高通量筛选与系统集成等方向的发展前景。本综述为推动电

-微生物协同固碳转化技术的深入研究与实际应用提供了重要参考与理论支撑。

Abstract

With the escalating challenge of global climate change

the development of efficient and sustainable carbon dioxide (CO

) conversion technologies has become a forefront priority in energy and environmental research. Among the diverse strategies

the upgrading of CO

into high-value

long-chain hydrocarbons (C

) not only alleviates the greenhouse effect but also provides a transformative pathway toward carbon neutrality and a circular carbon economy. Electrocatalysis and biocatalysis have each demonstrated unique advantages

including mild operating conditions

tunable selectivity

and modular integration capacity. Nevertheless

when deployed independently

both approaches suffer from intrinsic bottlenecks

such as limited carbon fixation efficiency

suboptimal product selectivity

and long-term instability. In recent years

electro-microbial hybrid systems have emerged as a promising solution by synergistically coupling electrochemical reduction with microbial metabolism. In such systems

electrical energy can directly fuel microbial CO

fixation

or electrocatalysts can reduce CO

into C

intermediates (e.g.

formate

acetate) that subsequently serve as versatile carbon feedstocks for microbial pathways. Through rationally engineered metabolic networks

these intermediates are further upgraded into multicarbon products

such as butanol

hexanoic acid

and olefins

thereby bridging the gap between simple reduction chemistry and complex biochemical synthesis. Depending on the degree of spatial

temporal

and energetic coupling

these systems can be broadly classified into in situ electro-microbe interfaces and ex situ cascade configurations

each offering distinct advantages and challenges. This review provides a comprehensive overview of recent advances in electro-microbial CO

conversion

with emphasis on key

scientific and technological frontiers: (i) control of product selectivity through pathway engineering and catalyst design

(ii) elucidation of direct versus mediated electron transfer mechanisms

(iii) strategies for designing robust and conductive bio-electrode interfaces

and (iv) approaches to enhance system durability and scalability. Finally

by highlighting the convergence of synthetic biology

materials science

and systems engineering

we outline future research opportunities

including precision genetic regulation

high-throughput catalyst-microbe screening

and integrated device architectures. This review aims to deliver mechanistic insights and design principles that will guide the next generation of electro-microbial technologies for carbon-neutral chemical manufacturing.

关键词

Keywords

references

YAN T X , CHEN X Y , KUMARI L , et al . Multiscale CO 2 electrocatalysis to C 2+ products: Reaction mechanisms, catalyst design, and device fabrication [J ] . Chemical Reviews , 2023 , 123 ( 17 ): 10530 - 10583 .

NAGARAJAN P , AUGUSTINE I J , ROSS M B . Strategies for multi-step carbon dioxide upgrading and valorization [J ] . Cell Reports Physical Science , 2023 , 4 ( 7 ): 101472 .

WANG Q , ZHANG J F , DAI Q L , et al . When green carbon plants meet synthetic biology [J ] . Modern Agriculture , 2023 , 1 ( 2 ): 98 - 111 .

QIAO J L , LIU Y Y , HONG F , et al . A review of catalysts for the electroreduction of carbon dioxide to produce low-carbon fuels [J ] . Chemical Society Reviews , 2014 , 43 ( 2 ): 631 - 675 .

NITOPI S , BERTHEUSSEN E , SCOTT B S , et al . Progress and perspectives of electrochemical CO 2 reduction on copper in aqueous electrolyte [J ] . Chemical Reviews , 2019 , 119 ( 12 ): 7610 - 7672 .

SUN Y , LUO Z H , QIU J S . Breakthrough in CO 2 electroreduction to multi‐carbon products at ampere‐level enabled by active sites engineering [J ] . Angewandte Chemie International Edition , 2024 , 136 ( 38 ): e202406879 .

SHUBA E S , KIFLE D . Microalgae to biofuels: 'Promising' alternative and renewable energy, review [J ] . Renewable and Sustainable Energy Reviews , 2018 , 81 : 743 - 755 .

POUREBRAHIMI S , PIROOZ M , AHMADI S , et al . Nanoengineering of metal-based electrocatalysts for carbon dioxide (CO 2 ) reduction: A critical review [J ] . Materials Today Physics , 2023 , 38 : 101250 .

IZADI P , HARNISCH F . Microbial | electrochemical CO 2 reduction: To integrate or not to integrate? [J ] . Joule , 2022 , 6 ( 5 ): 935 - 940 .

TAN X Y , NIELSEN J . The integration of bio-catalysis and electrocatalysis to produce fuels and chemicals from carbon dioxide [J ] . Chemical Society Reviews , 2022 , 51 ( 11 ): 4763 - 4785 .

ZHANG S X , JIANG J W , WANG H N , et al . A review of microbial electrosynthesis applied to carbon dioxide capture and conversion: The basic principles, electrode materials, and bioproducts [J ] . Journal of CO 2 Utilization , 2021 , 51 : 101640 .

MOSCOVIZ R , TOLEDO-ALARCóN J , TRABLY E , et al . Electro-fermentation: How to drive fermentation using electrochemical systems [J ] . Trends in Biotechnology , 2016 , 34 ( 11 ): 856 - 865 .

LUAN L K , JI X L , GUO B X , et al . Bioelectrocatalysis for CO 2 reduction: recent advances and challenges to develop a sustainable system for CO 2 utilization [J ] . Biotechnology Advances , 2023 , 63 : 108098 .

MAUREIRA D , ROMERO O , ILLANES A , et al . Industrial bioelectrochemistry for waste valorization: State of the art and challenges [J ] . Biotechnology Advances , 2023 , 64 : 108123 .

YU Y Y , WANG Y Z , FANG Z , et al . Single cell electron collectors for highly efficient wiring-up electronic abiotic/biotic interfaces [J ] . Nature Communication , 2020 , 11 ( 1 ): 4087 .

RABAEY K , ROZENDAL R A . Microbial electrosynthesis-revisiting the electrical route for microbial production [J ] . Nature Review Microbiology , 2010 , 8 ( 10 ): 706 - 716 .

FLEXER V , JOURDIN L . Purposely designed hierarchical porous electrodes for high rate microbial electrosynthesis of acetate from carbon dioxide [J ] . Accounts of Chemical Research , 2020 , 53 ( 2 ): 311 - 321 .

TAHIR K , MIRAN W , JANG J , et al . MXene-coated biochar as potential biocathode for improved microbial electrosynthesis system [J ] . Science of The Total Environment , 2021 , 773 : 145677 .

NIE H R , ZHANG T , CUI M M , et al . Improved cathode for high efficient microbial-catalyzed reduction in microbial electrosynthesis cells [J ] . Physical Chemistry Chemical Physics , 2013 , 15 ( 34 ): 14290 .

CUI M M , NIE H R , ZHANG T , et al . Three-dimensional hierarchical metal oxide-carbon electrode materials for highly efficient microbial electrosynthesis [J ] . Sustainable Energy & Fuels , 2017 , 1 ( 5 ): 1171 - 1176 .

XIA R X , CHENG J , CHEN Z , et al . Tailoring interfacial microbiome and charge dynamics via a rationally designed atomic-nanoparticle bridge for bio-electrochemical CO 2 -fixation [J ] . Energy & Environmental Science , 2023 , 16 ( 3 ): 1176 - 1186 .

XIA R X , FANG Y S , CHEN Z , et al . Manipulating electron extraction efficiency in microbial electrochemical carbon fixation via single-atom engineering [J ] . Materials Today , 2023 , 68 : 51 - 61 .

XIA R X , CHENG J , CHEN Z , et al . Revealing Co-N 4 @Co-NP bridge-enabled fast charge transfer and active intracellular methanogenesis in bio-electrochemical CO 2 -conversion with Methanosarcina Barkeri [J ] . Advanced Materials , 2023 , 35 ( 52 ): 2304920 .

ARYAL N , HALDER A , TREMBLAY P-L , et al . Enhanced microbial electrosynthesis with three-dimensional graphene functionalized cathodes fabricated via solvothermal synthesis [J ] . Electrochimica Acta , 2016 , 217 : 117 - 122 .

LI Q , FU Q , KOBAYASHI H , et al . GO/PEDOT modified biocathodes promoting CO 2 reduction to CH 4 in microbial electrosynthesis [J ] . Sustainable Energy & Fuels , 2020 , 4 ( 6 ): 2987 - 2997 .

JOURDIN L , GRIEGER T , MONETTI J , et al . High acetic acid production rate obtained by microbial electrosynthesis from carbon dioxide [J ] . Environmental Science & Technology , 2015 , 49 ( 22 ): 13566 - 13574 .

YU L P , YUAN Y , TANG J H , et al . Thermophilic Moorella thermoautotrophica -immobilized cathode enhanced microbial electrosynthesis of acetate and formate from CO 2 [J ] . Bioelectrochemistry , 2017 , 117 : 23 - 28 .

ZHANG T , NIE H R , BAIN T S , et al . Improved cathode materials for microbial electrosynthesis [J ] . Energy & Environmental Science , 2013 , 6 ( 1 ): 217 - 224 .

CHEN H , LI J W , FAN Q C , et al . A feasible strategy for microbial electrocatalytic CO 2 reduction via whole-cell-packed and exogenous-mediator-free rGO/ Shewanella biohydrogel [J ] . Chemical Engineering Journal , 2023 , 460 : 141863 .

BIAN B , ALQAHTANI M F , KATURI K P , et al . Porous nickel hollow fiber cathodes coated with CNTs for efficient microbial electrosynthesis of acetate from CO 2 using Sporomusa ovata [J ] . Journal of Materials Chemistry A , 2018 , 6 ( 35 ): 17201 - 17211 .

FU S F , ANGELIDAKI I , ZHANG Y F . In situ biogas upgrading by CO 2 -to-CH 4 bioconversion [J ] . Trends in Biotechnology , 2021 , 39 ( 4 ): 336 - 347 .

YANG Y , JI Z X , ZHOU J T , et al . Production of C 2+ products in novel microbial electrosynthesis coupled with anaerobic membrane bioreactor [J ] . Chemical Engineering Journal , 2023 , 476 : 146328 .

AMULYA K , VENKATA MOHAN S . Augmenting succinic acid production by bioelectrochemical synthesis: Influence of applied potential and CO 2 availability [J ] . Chemical Engineering Journal , 2021 , 411 : 128377 .

NEVIN K P , WOODARD T L , FRANKS A E , et al . Microbial electrosynthesis: Feeding microbes electricity to convert carbon dioxide and water to multicarbon extracellular organic compounds [J ] . mBio , 2010 , 1 ( 2 ): e00103-10 .

ARYAL N , TREMBLAY P-L , LIZAK D M , et al . Performance of different Sporomusa species for the microbial electrosynthesis of acetate from carbon dioxide [J ] . Bioresource Technology , 2017 , 233 : 184 - 90 .

LABELLE E V , MARSHALL C W , MAY H D . Microbiome for the electrosynthesis of chemicals from carbon dioxide [J ] . Accounts of Chemical Research , 2020 , 53 ( 1 ): 62 - 71 .

THARAK A , KATAKOJWALA R , KAJLA S , et al . Chemolithoautotrophic reduction of CO 2 to acetic acid in gas and gas-electro fermentation systems: Enrichment, microbial dynamics, and sustainability assessment [J ] . Chemical Engineering Journal , 2023 , 454 : 140200 .

MAYER F , ENZMANN F , LOPEZ A M , et al . Performance of different methanogenic species for the microbial electrosynthesis of methane from carbon dioxide [J ] . Bioresource Technology , 2019 , 289 : 121706 .

LIU C Q , XIAO J W , LI H Y , et al . High efficiency in-situ biogas upgrading in a bioelectrochemical system with low energy input [J ] . Water Research , 2021 , 197 : 117055 .

WANG D L , LIANG Q J , CHU N , et al . Deciphering mixotrophic microbial electrosynthesis with shifting product spectrum by genome-centric metagenomics [J ] . Chemical Engineering Journal , 2023 , 451 : 139010 .

LE G T H , MOHAMED H O , KIM H , et al . Microbial symbiotic electrobioconversion of carbon dioxide to biopolymer (poly (3-hydroxybutyrate)) via single-step microbial electrosynthesis cell [J ] . Chemical Engineering Journal , 2024 , 500 : 156635 .

SHI X C , TREMBLAY P L , WAN L L , et al . Improved robustness of microbial electrosynthesis by adaptation of a strict anaerobic microbial catalyst to molecular oxygen [J ] . Science of The Total Environment , 2021 , 754 : 142440 .

ROSENBAUM M , AULENTA F , VILLANO M , et al . Cathodes as electron donors for microbial metabolism: which extracellular electron transfer mechanisms are involved? [J ] . Bioresource Technology , 2011 , 102 ( 1 ): 324 - 333 .

JIANG Y , ZENG R J . Expanding the product spectrum of value added chemicals in microbial electrosynthesis through integrated process design-A review [J ] . Bioresource Technology , 2018 , 269 : 503 - 512 .

FENG Y H , XU M Y , TREMBLAY P-L , et al . The one-pot synthesis of a ZnSe/ZnS photocatalyst for H 2 evolution and microbial bioproduction [J ] . International Journal of Hydrogen Energy , 2021 , 46 ( 42 ): 21901 - 21911 .

NICHOLS E M , GALLAGHER J J , LIU C , et al . Hybrid bioinorganic approach to solar-to-chemical conversion [J ] . Proceedings of the National Academy of Sciences , 2015 , 112 ( 37 ): 11461 - 11466 .

TREMBLAY P-L , XU M Y , CHEN Y M , et al . Nonmetallic abiotic-biological hybrid photocatalyst for visible water splitting and carbon dioxide reduction [J ] . iScience , 2020 , 23 ( 1 ): 100784 .

TIAN S H , WANG H Q , DONG Z W , et al . Mo 2 C-induced hydrogen production enhances microbial electrosynthesis of acetate from CO 2 reduction [J ] . Biotechnology for Biofuels , 2019 , 12 ( 1 ): 71 .

TORELLA J P , GAGLIARDI C J , CHEN J S , et al . Efficient solar-to-fuels production from a hybrid microbial-water-splitting catalyst system [J ] . Proceedings of the National Academy of Sciences , 2015 , 112 ( 8 ): 2337 - 2342 .

CHONG LIU , COLóN B C , ZIESACK M , et al . Water splitting-biosynthetic system with CO 2 reduction efficiencies exceeding photosynthesis [J ] . Science , 2016 , 352 ( 6290 ): 1210 - 1213 .

JIANG Y , CHU N , ZHANG W , et al . Zinc: A promising material for electrocatalyst-assisted microbial electrosynthesis of carboxylic acids from carbon dioxide [J ] . Water Research , 2019 , 159 : 87 - 94 .

IZADI P , FONTMORIN J-M , LIM S S , et al . Enhanced bio-production from CO 2 by microbial electrosynthesis (MES) with continuous operational mode [J ] . Faraday Discussions , 2021 , 230 : 344 - 359 .

ARYAL N , WAN L L , OVERGAARD M H , et al . Increased carbon dioxide reduction to acetate in a microbial electrosynthesis reactor with a reduced graphene oxide-coated copper foam composite cathode [J ] . Bioelectrochemistry , 2019 , 128 : 83 - 93 .

JIANG Y , LIANG Q J , CHU N , et al . A slurry electrode integrated with membrane electrolysis for high-performance acetate production in microbial electrosynthesis [J ] . Science of The Total Environment , 2020 , 741 : 140198 .

ROHBOHM N , SUN T , BLASCO-GóMEZ R , et al . Carbon oxidation with sacrificial anodes to inhibit O 2 evolution in membrane-less bioelectrochemical systems for microbial electrosynthesis [J ] . EES Catalysis , 2023 , 1 ( 6 ): 972 - 986 .

CAI W F , CUI K , LIU Z Z , et al . An electrolytic-hydrogen-fed moving bed biofilm reactor for efficient microbial electrosynthesis of methane from CO 2 [J ] . Chemical Engineering Journal , 2022 , 428 : 132093 .

BAJRACHARYA S , KRIGE A , MATSAKAS L , et al . Dual cathode configuration and headspace gas recirculation for enhancing microbial electrosynthesis using Sporomusa ovata [J ] . Chemosphere , 2022 , 287 : 132188 .

GAO J Y , CAI W F , BAI J R , et al . Strengthening H 2 gas-liquid mass transfer using superaerophobic cathodes for enhanced methane production from CO 2 in H 2 -mediated microbial electrosynthesis system [J ] . Bioresource Technology , 2025 , 417 : 131850 .

RODRIGUES R M , GUAN X , IñIGUEZ J A , et al . Perfluorocarbon nanoemulsion promotes the delivery of reducing equivalents for electricity-driven microbial CO 2 reduction [J ] . Nature Catalysis , 2019 , 2 ( 5 ): 407 - 414 .

BAJRACHARYA S , TER HEIJNE A , DOMINGUEZ BENETTON X , et al . Carbon dioxide reduction by mixed and pure cultures in microbial electrosynthesis using an assembly of graphite felt and stainless steel as a cathode [J ] . Bioresource Technology , 2015 , 195 : 14 - 24 .

BAJRACHARYA S , VANBROEKHOVEN K , BUISMAN C J N , et al . Bioelectrochemical conversion of CO 2 to chemicals: CO 2 as a next generation feedstock for electricity-driven bioproduction in batch and continuous modes [J ] . Faraday Discussions , 2017 , 202 : 433 - 449 .

VELVIZHI G , SARKAR O , ROVIRA-ALSINA L , et al . Conversion of carbon dioxide to value added products through anaerobic fermentation and electro fermentation: A comparative approach [J ] . International Journal of Hydrogen Energy , 2022 , 47 ( 34 ): 15442 - 15455 .

CHU W J , WU Z Y , LI X H , et al . Reduction short-chain volatile fatty acids and CO 2 into alcohols in microbial electrosynthesis system [J ] . Renewable Energy , 2024 , 237 : 121751 .

BATLLE-VILANOVA P , PUIG S , GONZALEZ-OLMOS R , et al . Continuous acetate production through microbial electrosynthesis from CO 2 with microbial mixed culture [J ] . Journal of Chemical Technology & Biotechnology , 2015 , 91 ( 4 ): 921 - 927 .

XIAO S , FU Q , XIONG K R , et al . Parametric study of biocathodes in microbial electrosynthesis for CO 2 reduction to CH 4 with a direct electron transfer pathway [J ] . Renewable Energy , 2020 , 162 : 438 - 446 .

BLANCHET E , DUQUENNE F , RAFRAFI Y , et al . Importance of the hydrogen route in up-scaling electrosynthesis for microbial CO 2 reduction [J ] . Energy & Environmental Science , 2015 , 8 ( 12 ): 3731 - 3744 .

JOURDIN L , FREGUIA S , FLEXER V , et al . Bringing high-rate, CO 2 -based microbial electrosynthesis closer to practical implementation through improved electrode design and operating conditions [J ] . Environmental Science & Technology , 2016 , 50 ( 4 ): 1982 - 1989 .

ROY M , YADAV R , CHIRANJEEVI P , et al . Direct utilization of industrial carbon dioxide with low impurities for acetate production via microbial electrosynthesis [J ] . Bioresource Technology , 2021 , 320 : 124289 .

AMMAM F , TREMBLAY P-L , LIZAK D M , et al . Effect of tungstate on acetate and ethanol production by the electrosynthetic bacterium Sporomusa ovata [J ] . Biotechnology for Biofuels , 2016 , 9 ( 1 ): 163 .

VILLANO M , AULENTA F , CIUCCI C , et al . Bioelectrochemical reduction of CO 2 to CH 4 via direct and indirect extracellular electron transfer by a hydrogenophilic methanogenic culture [J ] . Bioresource Technology , 2010 , 101 ( 9 ): 3085 - 3090 .

XIE Y C , ERŞAN S , GUAN X , et al . Unexpected metabolic rewiring of CO 2 fixati on in H 2 -mediated materials-biology hybrids [J ] . Proceedings of the National Academy of Sciences , 2023 , 120 ( 42 ): e2308373120 .

BOLOGNESI S , BAñERAS L , PERONA-VICO E , et al . Carbon dioxide to bio-oil in a bioelectrochemical system-assisted microalgae biorefinery process [J ] . Sustainable Energy & Fuels , 2022 , 6 ( 1 ): 150 - 161 .

DI STADIO G , ORITA I , NAKAMURA R , et al . Gas fermentation combined with water electrolysis for production of polyhydroxyalkanoate copolymer from carbon dioxide by engineered Ralstonia eutropha [J ] . Bioresource Technology , 2024 , 394 : 130266 .

WU H L , PAN H J , LI Z J , et al . Efficient production of lycopene from CO 2 via microbial electrosynthesis [J ] . Chemical Engineering Journal , 2022 , 430 : 132943 .

KRIEG T , SYDOW A , FAUST S , et al . CO 2 to terpenes: autotrophic and electroautotrophic α-humulene production with Cupriavidus necator [J ] . Angewandte Chemie International Edition , 2018 , 57 ( 7 ): 1879 - 1882 .

STEINBUSCH K J J , HAMELERS H V M , SCHAAP J D , et al . Bioelectrochemical ethanol production through mediated acetate reduction by mixed cultures [J ] . Environmental Science & Technology , 2010 , 44 ( 1 ): 513 - 517 .

SONG J , KIM Y , LIM M , et al . Microbes as electrochemical CO 2 conversion catalysts [J ] . ChemSusChem , 2011 , 4 ( 5 ): 587 - 590 .

SEELAJAROEN H , HABERBAUER M , HEMMELMAIR C , et al . Enhanced bio-electrochemical reduction of carbon dioxide by using neutral red as a redox mediator [J ] . ChemBioChem , 2019 , 20 ( 9 ): 1196 - 1205 .

SONG Y E , KIM C , BAEK J , et al . Increased CODH activity in a bioelectrochemical system improves microbial electrosynthesis with CO [J ] . Sustainable Energy & Fuels , 2020 , 4 ( 12 ): 5952 - 5957 .

YANG H Y , WANG Y X , HE C S , et al . Redox mediator-modified biocathode enables highly efficient microbial electro-synthesis of methane from carbon dioxide [J ] . Applied Energy , 2020 , 274 : 115292 .

CHEN H , SIMOSKA O , LIM K , et al . Fundamentals, applications, and future directions of bioelectrocatalysis [J ] . Chemical Reviews , 2020 , 120 ( 23 ): 12903 - 12993 .

LUO H P , QI J X , ZHOU M Z , et al . Enhanced electron transfer on microbial electrosynthesis biocathode by polypyrrole-coated acetogens [J ] . Bioresource Technology , 2020 , 309 : 123322 .

JOURDIN L , FREGUIA S , DONOSE B C , et al . A novel carbon nanotube modified scaffold as an efficient biocathode material for improved microbial electrosynthesis [J ] . Journal of Materials Chemistry A , 2014 , 2 ( 32 ): 13093 - 13102 .

HAN S , LIU H , ZHOU C , et al . Growth of carbon nanotubes on graphene as 3D biocathode for NAD + /NADH balance model and high-rate production in microbial electrochemical synthesis from CO 2 [J ] . Journal of Materials Chemistry A , 2019 , 7 ( 3 ): 1115 - 1123 .

MA Z S , YANG Z L , LAI W C , et al . CO 2 electroreduction to multicarbon products in strongly acidic electrolyte via synergistically modulating the local microenvironment [J ] . Nature Communications , 2022 , 13 ( 1 ): 7596 .

SONG T S , ZHANG H , LIU H , et al . High efficiency microbial electrosynthesis of acetate from carbon dioxide by a self-assembled electroactive biofilm [J ] . Bioresource Technology , 2017 , 243 : 573 - 582 .

XIA R X , CHENG J , CHEN Z , et al . Atomic pyridinic nitrogen as highly active metal-free coordination sites at the biotic-abiotic interface for bio-electrochemical CO 2 reduction [J ] . Small , 2023 , 20 ( 18 ): 2306331 .

LIU X , HUANG L Y , RENSING C , et al . Syntrophic interspecies electron transfer drives carbon fixation and growth by Rhodopseudomonas palustris under dark, anoxic conditions [J ] . Science Advances , 2017 , 7 : eabh1852 .

VU M T , NOORI M T , MIN B . Conductive magnetite nanoparticles trigger syntrophic methane production in single chamber microbial electrochemical systems [J ] . Bioresource Technology , 2020 , 296 : 122265 .

LI H , OPGENORTH P H , WERNICK D G , et al . Integrated electromicrobial conversion of CO 2 to higher alcohols [J ] . Science , 2012 , 335 ( 6076 ): 1596 .

CHEN X Y , FENG Q Y , CAI Q H , et al . Mn 3 O 4 nanozyme coating accelerates nitrate reduction and decreases N 2 O emission during photoelectrotrophic denitrification by Thiobacillus denitrificans -CdS [J ] . Environmental Science & Technology , 2020 , 54 ( 17 ): 10820 - 10830 .

CHEN K , MA C L , CHENG X L , et al . Construction of Cupriavidus necator displayed with superoxide dismutases for enhanced growth in bioelectrochemical systems [J ] . Bioresources and Bioprocessing , 2023 , 10 ( 1 ): 36 .

IM C , VALGEPEA K , MODIN O , et al . Clostridium ljungdahlii as a biocatalyst in microbial electrosynthesis--Effect of culture conditions on product formation [J ] . Bioresource Technology Reports , 2022 , 19 : 101156 .

LI Y X , LUO Q L , SU J Y , et al . Metabolic regulation of Shewanella oneidensis for microbial electrosynthesis: From extracellular to intracellular [J ] . Metabolic Engineering , 2023 , 80 : 1 - 11 .

TU W M , XU J B , THOMPSON I P , et al . Engineering artificial photosynthesis based on rhodopsin for CO 2 fixation [J ] . Nature Communications , 2023 , 14 ( 1 ): 8012 .

ZHANG P , CHEN K N , XU B , et al . Chem-bio interface design for rapid conversion of CO 2 to bioplastics in an integrated system [J ] . Chem , 2022 , 8 ( 12 ): 3363 - 3381 .

LIU X J , ZHANG K , SUN Y D , et al . Upgrading CO 2 into acetate on Bi 2 O 3 @carbon felt integrated electrode via coupling electrocatalysis with microbial synthesis [J ] . Susmat , 2023 , 3 ( 2 ): 235 - 247 .

BI H R , WANG K , XU C C , et al . Biofuel synthesis from carbon dioxide via a bio-electrocatalysis system [J ] . Chem Catalysis , 2023 , 3 ( 3 ): 100557 .

ZHANG M , CAO A H , XIANG Y C , et al . Strongly coupled Ag/Sn-SnO 2 nanosheets toward CO 2 electroreduction to pure HCOOH solutions at ampere‑level current [J ] . Nano-Micro Letters , 2024 , 16 : 50 .

HAN J Y , BIN T , AN P F , et al . Structuring Cu membrane electrode for maximizing ethylene yield from CO 2 electroreduction [J ] . Advanced Materials , 2024 , 36 ( 21 ): 2313926 .

CUI H J , LIU W S , MA C L , et al . Converting CO 2 to single-cell protein via an integrated electrocatalytic-biosynthetic system [J ] . Applied Catalysis B: Environment and Energy , 2024 , 350 : 123946 .

LIM J , CHOI S Y , LEE J W , et al . Biohybrid CO 2 electrolysis for the direct synthesis of polyesters from CO 2 [J ] . Proceedings of the National Academy of Sciences , 2023 , 120 ( 14 ): e2221438120 .

ZHENG T T , ZHANG M L , WU L H , et al . Upcycling CO 2 into energy-rich long-chain compounds via electrochemical and metabolic engineering [J ] . Nature Catalysis , 2022 , 5 ( 5 ): 388 - 396 .

ZHANG G R , JI N , LYU S , et al . Artificial synthesis of polyesters at ambient condition via consecutive CO 2 electrolysis and fermentation [J ] . Nano Research , 2024 , 17 : 6016 - 6025 .

FAN L , ZHU Z H , ZHAO S Y , et al . Blended nexus molecules promote CO 2 to L-tyrosine conversion [J ] . Science Advances , 2024 , 10 ( 36 ): eado1352 .

HAN L , LI Y , WANG X Y , et al . Spatially Decoupled Electro-Biosystem for Eﬃcient CO 2 -to-Chemicals Conversion via Tandem Catalysis [J ] . Advanced Energy Materials , 2025 .

LI C B , GUO M M , YANG B , et al . Efficient and scalable upcycling of oceanic carbon sources into bioplastic monomers [J ] . Nature Catalysis , 2025 .

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