Applications of functional framework materials in C<sub>1</sub> biotransformation

DI Zeyan; ZHOU Shuo; YANG Mingfang; LIU Xin; CHEN Yao

doi:10.12211/2096-8280.2025-003

您当前的位置：

首页 >

文章列表页 >

Applications of functional framework materials in C₁ biotransformation

Invited Review | 更新时间：2026-07-03

- Applications of functional framework materials in C₁ biotransformation
- Synthetic Biology Journal Vol. 7, Issue 3, Pages: 567-587(2026)
- 作者机构：
  
  1.中国科学院过程工程研究所，生物药制备与递送全国重点实验室，北京 100190
  2.南开大学药物化学生物全国重点实验室，天津 300071
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2025-003
  CLC： Q81
- Received：02 January 2025，
  
  Revised：2025-03-09，
  
  Published：30 June 2026
- 稿件说明：
移动端阅览
狄泽燕，周铄，杨铭方，刘昕，陈瑶. 功能框架材料在一碳生物转化中的应用［J］. 合成生物学， 2026， 7（3）： 567-587

DI Zeyan， ZHOU Shuo， YANG Mingfang， LIU Xin， CHEN Yao. Applications of functional framework materials in C₁ biotransformation［J］. Synthetic Biology Journal， 2026， 7（3）： 567-587 DOI: 10.12211/2096-8280.2025-003.
狄泽燕，周铄，杨铭方，刘昕，陈瑶. 功能框架材料在一碳生物转化中的应用［J］. 合成生物学， 2026， 7（3）： 567-587 DOI： 10.12211/2096-8280.2025-003.

DI Zeyan， ZHOU Shuo， YANG Mingfang， LIU Xin， CHEN Yao. Applications of functional framework materials in C₁ biotransformation［J］. Synthetic Biology Journal， 2026， 7（3）： 567-587 DOI: 10.12211/2096-8280.2025-003. DOI：

摘要

一碳化合物（CO₂、甲烷、甲醇等）的生物转化是实现绿色生物制造的重要途径，但其效率受限于气相底物捕获困难、生物催化剂稳定性不足及辅因子再生成本高、操作复杂等问题。功能框架材料［金属有机框架（MOF）、共价有机框架（COF）和氢键有机框架（HOF）等］凭借其高比表面积、可调孔道结构和多功能特性，为解决上述挑战提供了新思路。本文系统综述了功能框架材料在一碳生物转化中的最新研究进展：①作为酶固定化载体，显著提升催化稳定性与效率；②构建级联催化体系；③开发框架材料基人工酶；④协同微生物催化。然而，功能框架材料在一碳生物转化中应用面临固定化酶种类受限及传质阻力、天然微生物和酶效率低、规模化成本高及工业化适配性亟待突破等挑战。未来需重点优化定向固定化策略以减少传质限制；利用合成生物学改造微生物和酶；开发低成本、可大量制备的框架材料，突破规模化生产与工业适配性瓶颈，并评估全生命周期环境影响。功能框架材料与生物催化的深度融合将为一碳资源的高值化利用提供变革性技术支撑。

Abstract

The bioconversion of one-carbon (C

) compounds (CO

methane

methanol

etc

.) is a critical pathway for green biomanufacturing

yet its efficiency is constrained by challenges such as the difficulty in capturing gaseous substrates

insufficient stability of biocatalysts under harsh environmental conditions

high cost and operational complexity of cofactor regeneration

and inherent inefficiencies of natural microbial systems. Functional framework materials

including metal-organic frameworks (MOFs)

covalent organic frameworks (COFs)

and hydrogen-bonded organic frameworks (HOFs)

offer potential solutions to these challenges due to their exceptional structural versatility

high surface area

and tunable physicochemical properties. These materials enable precise control over interactions for enzyme molecules/microbes

substrate enrichment

and catalytic microenvironment optimization. This review systematically summarizes recent advances in the applications of functional framework materials for C

bioconversion: ①serving as enzyme immobilization carriers to enhance catalytic robustness and operational stability

②constructing multi-enzyme cascade systems for sequential substrate conversion

③developing framework-based artificial enzymes mimicking natural catalytic mechanisms

and ④ synergizing microbial catalysis through material-mediated nutrient supply and metabolic regulation. By integrating material science with bioc

atalysis

these approaches address critical limitations in substrate accessibility

reaction kinetics

and system scalability. However

functional framework materials in C

bioconversion face challenges

including limited diversity in immobilized different enzymes

mass transfer constraints due to pore structure mismatches

low compatibility of natural microbial strains with industrial processes

and high costs associated with material synthesis and scale-up. Furthermore

the long-term stability of frameworks under industrial operating conditions (

e.g

humidity

acidic environments) remains a significant hurdle

alongside the technical complexity of co-immobilizing enzymes and microbial cells for hybrid catalytic systems. Future efforts should prioritize: ①designing hierarchical porous frameworks to minimize mass transfer barriers

②leveraging synthetic biology to engineer microbial chassis with enhanced C

assimilation pathways

③developing cost-effective

scalable synthesis methods for framework materials

④ expanding the functional scope of frameworks to include non-metallic catalytic centers and stimuli-responsive properties

and ⑤ validating industrial compatibility through material densification and lifecycle sustainability assessments. The deep integration of functional framework materials with biocatalysis will provide transformative technological support for the high-value utilization of C

resources.

关键词

Keywords

references

LIU K G , BIGDELI F , PANJEHPOUR A , et al . Metal organic framework composites for reduction of CO 2 [J ] . Coordination Chemistry Reviews , 2023 , 493 : 215257 .

LI D D , KASSYMOVA M , CAI X C , et al . Photocatalytic CO 2 reduction over metal-organic framework-based materials [J ] . Coordination Chemistry Reviews , 2020 , 412 : 213262 .

史硕博 , 王禹博 , 乔玮博 , 等 . 第三代生物炼制的挑战与机遇 [J ] . 科学通报 , 2023 , 68 ( 19 ): 2489 - 2503 .

SHI S B , WANG Y B , QIAO W B , et al . Challenges and opportunities in the third-generation biorefinery [J ] . Chinese Science Bulletin , 2023 , 68 ( 19 ): 2489 - 2503 .

WANG K , SU C S , BI H R , et al . The transition from 2G to 3G-feedstocks enabled efficient production of fuels and chemicals [J ] . Green Energy & Environment , 2024 , 9 ( 11 ): 1759 - 1770 .

LV X Q , YU W W , ZHANG C Y , et al . C 1 -based biomanufacturing: advances, challenges and perspectives [J ] . Bioresource Technology , 2023 , 367 : 128259 .

QIAO Y Y , MA W Y , ZHANG S J , et al . Artificial multi-enzyme cascades and whole-cell transformation for bioconversion of C 1 compounds: advances, challenge and perspectives [J ] . Synthetic and Systems Biotechnology , 2023 , 8 ( 4 ): 578 - 583 .

叶伟 , 李芮 , 姜卫红 , 等 . 二氧化碳微生物转化与体外酶催化体系研究进展 [J ] . 合成生物学 , 2023 , 4 ( 6 ): 1223 - 1245 .

YE W , LI R , JIANG W H , et al . Microbial conversion and in vitro enzymatic catalysis for carbon dioxide utilization: a review [J ] . Synthetic Biology Journal , 2023 , 4 ( 6 ): 1223 - 1245 .

刘洁铮 , 刘敏 , 赵广 , 等 . 一碳化合物非天然生物转化的研究进展 [J ] . 激光生物学报 , 2024 , 33 ( 5 ): 385 - 399 .

LIU J Z , LIU M , ZHAO G , et al . Progress in artificial microbiol transformation of one-carbon compounds [J ] . Acta Laser Biology Sinica , 2024 , 33 ( 5 ): 385 - 399 .

WANG K Y , ZHANG J Q , HSU Y C , et al . Bioinspired framework catalysts: from enzyme immobilization to biomimetic catalysis [J ] . Chemical Reviews , 2023 , 123 ( 9 ): 5347 - 5420 .

CHEN L Y , LUQUE R , LI Y W . Controllable design of tunable nanostructures inside metal-organic frameworks [J ] . Chemical Society Reviews , 2017 , 46 ( 15 ): 4614 - 4630 .

穆翠枝 , 徐峰 , 雷威 . 功能金属-有机骨架材料的应用 [J ] . 化学进展 , 2007 , 19 ( 9 ): 1345 - 1356 .

MU C Z , XU F , LEI W . Application of functional metal-organic framework materials [J ] . Progress in Chemistry , 2007 , 19 ( 9 ): 1345 - 1356 .

ZHOU H C , LONG J R , YAGHI O M . Introduction to metal-organic frameworks [J ] . Chemical Reviews , 2012 , 112 ( 2 ): 673 - 674 .

ZHOU H C , KITAGAWA S . Metal-organic frameworks (MOFs) [J ] . Chemical Society Reviews , 2014 , 43 ( 16 ): 5415 - 5418 .

CRAVILLON J , MÜNZER S , LOHMEIER S J , et al . Rapid room-temperature synthesis and characterization of nanocrystals of a prototypical zeolitic imidazolate framework [J ] . Chemistry of Materials , 2009 , 21 ( 8 ): 1410 - 1412 .

张荣 , 谢有超 , 喻昌木 , 等 . MOFs催化剂的设计合成与应用研究进展 [J ] . 化工新型材料 , 2021 , 49 ( 1 ): 223 - 228 .

ZHANG R , XIE Y C , YU C M , et al . Research progress of design, synthesis and application of MOFs catalyst [J ] . New Chemical Materials , 2021 , 49 ( 1 ): 223 - 228 .

XIAO K R , SHU B , LV K L , et al . Recent progress of MIL MOF materials in degradation of organic pollutants by Fenton reaction [J ] . Catalysts , 2023 , 13 ( 4 ): 734 .

HORCAJADA P , CHALATI T , SERRE C , et al . Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging [J ] . Nature Materials , 2010 , 9 ( 2 ): 172 - 178 .

WANG D Y , YAO H C , YE J S , et al . Metal-organic frameworks (MOFs): classification, synthesis, modification, and biomedical applications [J ] . Small , 2024 , 20 ( 47 ): 2404350 .

KOUSER S , HEZAM A , NAGESH KHADRI M J , et al . A review on zeolite imidazole frameworks: synthesis, properties, and applications [J ] . Journal of Porous Materials , 2022 , 29 ( 3 ): 663 - 681 .

YANG X G , ZHANG J R , TIAN X K , et al . Enhanced activity of enzyme immobilized on hydrophobic ZIF-8 modified by Ni 2+ ions [J ] . Angewandte Chemie International Edition , 2023 , 62 ( 7 ): e202216699 .

王茀学 , 王崇臣 , 王鹏 , 等 . UiO系列金属-有机骨架的合成方法与应用 [J ] . 无机化学学报 , 2017 , 33 ( 5 ): 713 - 737 .

WANG F X , WANG C C , WANG P , et al . Syntheses and applications of UiO series of MOFs [J ] . Chinese Journal of Inorganic Chemistry , 2017 , 33 ( 5 ): 713 - 737 .

ZHOU J , GU S X , XIANG Y Q , et al . UiO-67: a versatile metal-organic framework for diverse applications [J ] . Coordination Chemistry Reviews , 2025 , 526 : 216354 .

BEUERLE F , GOLE B . Covalent organic frameworks and cage compounds: design and applications of polymeric and discrete organic scaffolds [J ] . Angewandte Chemie International Edition , 2018 , 57 ( 18 ): 4850 - 4878 .

TRAN Q N , LEE H J , TRAN N . Covalent organic frameworks: from structures to applications [J ] . Polymers , 2023 , 15 ( 5 ): 1279 .

EL-KADERI H M , HUNT J R , MENDOZA-CORTÉS J L , et al . Designed synthesis of 3D covalent organic frameworks [J ] . Science , 2007 , 316 ( 5822 ): 268 - 272 .

CÔTÉ A P , BENIN A I , OCKWIG N W , et al . Porous, crystalline, covalent organic frameworks [J ] . Science , 2005 , 310 ( 5751 ): 1166 - 1170 .

KHAN M M , RAHMAN A , MATUSSIN S N . Recent progress of metal-organic frameworks and metal-organic frameworks-based heterostructures as photocatalysts [J ] . Nanomaterials , 2022 , 12 ( 16 ): 2820 .

HISAKI I , XIN C , TAKAHASHI K , et al . Designing hydrogen-bonded organic frameworks (HOFs) with permanent porosity [J ] . Angewandte Chemie International Edition , 2019 , 58 ( 33 ): 11160 - 11170 .

HAN Y F , YUAN Y X , WANG H B . Porous hydrogen-bonded organic frameworks [J ] . Molecules , 2017 , 22 ( 2 ): 266 .

LIN R B , CHEN B L . Hydrogen-bonded organic frameworks: chemistry and functions [J ] . Chem , 2022 , 8 ( 8 ): 2114 - 2135 .

SONG X Y , WANG Y , WANG C , et al . Self-healing hydrogen-bonded organic frameworks for low-concentration ammonia capture [J ] . Journal of the American Chemical Society , 2024 , 146 ( 1 ): 627 - 634 .

SHANG Y X , MA L S , KANG Z X , et al . Integrated monomer synthesis and framework assembly: achieving isoreticular modulation of hydrogen-bonded organic frameworks [J ] . Angewandte Chemie International Edition , 2025 , 64 ( 5 ): e202416966 .

LI Y B , WANG X , ZHANG H , et al . A microporous hydrogen bonded organic framework for highly selective separation of carbon dioxide over acetylene [J ] . Angewandte Chemie International Edition , 2023 , 62 ( 39 ): e202311419 .

FENG J , HUANG Q Y , ZHANG C , et al . Review of covalent organic frameworks for enzyme immobilization: strategies, applications, and prospects [J ] . International Journal of Biological Macromolecules , 2023 , 248 : 125729 .

BASSO A , SERBAN S . Industrial applications of immobilized enzymes: a review [J ] . Molecular Catalysis , 2019 , 479 : 110607 .

LIESE A , HILTERHAUS L . Evaluation of immobilized enzymes for industrial applications [J ] . Chemical Society Reviews , 2013 , 42 ( 15 ): 6236 - 6249 .

LIU D M , CHEN J , SHI Y P . Advances on methods and easy separated support materials for enzymes immobilization [J ] . TrAC Trends in Analytical Chemistry , 2018 , 102 : 332 - 342 .

SILVA ALMEIDA C , SIMÃO NETO F , DA SILVA SOUSA P , et al . Enhancing lipase immobilization via physical adsorption: advancements in stability, reusability, and industrial applications for sustainable biotechnological processes [J ] . ACS Omega , 2024 , 9 ( 47 ): 46698 - 46732 .

WANG X , MAKAL T A , ZHOU H C . Protein immobilization in metal-organic frameworks by covalent binding [J ] . Australian Journal of Chemistry , 2014 , 67 ( 11 ): 1629 - 1631 .

MEHTA J , BHARDWAJ N , BHARDWAJ S K , et al . Recent advances in enzyme immobilization techniques: metal-organic frameworks as novel substrates [J ] . Coordination Chemistry Reviews , 2016 , 322 : 30 - 40 .

SCHOEVAART R , WOLBERS M W , GOLUBOVIC M , et al . Preparation, optimization, and structures of cross-linked enzyme aggregates (CLEAs) [J ] . Biotechnology and Bioengineering , 2004 , 87 ( 6 ): 754 - 762 .

ZHU Q Q , ZHENG Y L , ZHANG Z J , et al . Enzyme immobilization on covalent organic framework supports [J ] . Nature Protocols , 2023 , 18 ( 10 ): 3080 - 3125 .

FAN X Y , ZHAI S B , XUE S , et al . Enzyme immobilization using covalent organic frameworks: from synthetic strategy to COFs functional role [J ] . ACS Applied Materials & Interfaces , 2024 , 16 ( 31 ): 40371 - 40390 .

SICARD C . In situ enzyme immobilization by covalent organic frameworks [J ] . Angewandte Chemie International Edition , 2023 , 62 ( 1 ): e202213405 .

FENG Y M , XU Y , LIU S C , et al . Recent advances in enzyme immobilization based on novel porous framework materials and its applications in biosensing [J ] . Coordination Chemistry Reviews , 2022 , 459 : 214414 .

LEE S H , CHOU A , NATTERMANN M , et al . Identification of 2-hydroxyacyl-CoA synthases with high acyloin condensation activity for orthogonal one-carbon bioconversion [J ] . ACS Catalysis , 2023 , 13 ( 18 ): 12007 - 12020 .

NETTO C G C M , NAKAMURA M , ANDRADE L H , et al . Improving the catalytic activity of formate dehydrogenase from Candida boidinii by using magnetic nanoparticles [J ] . Journal of Molecular Catalysis B: Enzymatic , 2012 , 84 : 136 - 143 .

JUN S H , YANG J S , JEON H , et al . Stabilized and immobilized carbonic anhydrase on electrospun nanofibers for enzymatic CO 2 conversion and utilization in expedited microalgal growth [J ] . Environmental Science & Technology , 2020 , 54 ( 2 ): 1223 - 1231 .

SALEHIZADEH H , YAN N , FARNOOD R . Recent advances in microbial CO 2 fixation and conversion to value-added products [J ] . Chemical Engineering Journal , 2020 , 390 : 124584 .

WOOLERTON T W , SHEARD S , REISNER E , et al . Efficient and clean photoreduction of CO 2 to CO by enzyme-modified TiO 2 nanoparticles using visible light [J ] . Journal of the American Chemical Society , 2010 , 132 ( 7 ): 2132 - 2133 .

LUO J Q , MEYER A S , MATEIU R V , et al . Cascade catalysis in membranes with enzyme immobilization for multi-enzymatic conversion of CO 2 to methanol [J ] . New Biotechnology , 2015 , 32 ( 3 ): 319 - 327 .

葛喜珍 , 赵有玺 , 刘晓宇 , 等 . 生物固定CO 2 代谢途径及关键酶的研究进展 [J ] . 北京联合大学学报(自然科学版) , 2013 , 27 ( 1 ): 63 - 68 .

GE X Z , ZHAO Y X , LIU X Y , et al . Research advances in biological CO 2 fixation pathways and key enzymes [J ] . Journal of Beijing Union University (Natural Sciences) , 2013 , 27 ( 1 ): 63 - 68 .

JIA Z C , DANG J N , WEN G B , et al . Constructing nanocaged enzymes for synergistic catalysis of CO 2 reduction [J ] . Advanced Science , 2023 , 10 ( 20 ): 2300752 .

YAN L H , LIU G H , LIU J Q , et al . Hierarchically porous metal organic framework immobilized formate dehydrogenase for enzyme electrocatalytic CO 2 reduction [J ] . Chemical Engineering Journal , 2022 , 450 : 138164 .

SILVERMAN D N , LINDSKOG S . The catalytic mechanism of carbonic anhydrase: implications of a rate-limiting protolysis of water [J ] . Accounts of Chemical Research , 1988 , 21 ( 1 ): 30 - 36 .

ZHANG Y M , WANG H X , LIU J D , et al . Enzyme-embedded metal-organic framework membranes on polymeric substrates for efficient CO 2 capture [J ] . Journal of Materials Chemistry A , 2017 , 5 ( 37 ): 19954 - 19962 .

ZHANG S H , DU M E , SHAO P J , et al . Carbonic anhydrase enzyme-MOFs composite with a superior catalytic performance to promote CO 2 absorption into tertiary amine solution [J ] . Environmental Science & Technology , 2018 , 52 ( 21 ): 12708 - 12716 .

CHAI M , RAZMJOU A , CHEN V . Metal-organic-framework protected multi-enzyme thin-film for the cascade reduction of CO 2 in a gas-liquid membrane contactor [J ] . Journal of Membrane Science , 2021 , 623 : 118986 .

CHAI M , RAZAVI BAZAZ S , DAIYAN R , et al . Biocatalytic micromixer coated with enzyme-MOF thin film for CO 2 conversion to formic acid [J ] . Chemical Engineering Journal , 2021 , 426 : 130856 .

BANERJEE T , GOTTSCHLING K , SAVASCI G , et al . H 2 evolution with covalent organic framework photocatalysts [J ] . ACS Energy Letters , 2018 , 3 ( 2 ): 400 - 409 .

HUANG W , LI Y G . Semiconducting 2D covalent organic frameworks: a new opportunity for efficient solar fuel production [J ] . Chinese Journal of Chemistry , 2019 , 37 ( 12 ): 1291 - 1292 .

HUANG W , LUO W , LI Y G . Two-dimensional semiconducting covalent organic frameworks for photocatalytic solar fuel production [J ] . Materials Today , 2020 , 40 : 160 - 172 .

PEI R , LIU J , JING C Y , et al . A multienzyme cascade pathway immobilized in a hydrogen-bonded organic framework for the conversion of CO 2 [J ] . Small , 2024 , 20 ( 14 ): 2306117 .

LUAN L K , ZHANG Y F , JI X L , et al . Electro-driven multi-enzymatic cascade conversion of CO 2 to ethylene glycol in nano-reactor [J ] . Advanced Science , 2024 , 11 ( 41 ): 2407204 .

ZHANG B Y , WU Z H , CHU Z Y , et al . Carbonic anhydrase-embedded hydrogen-bonded organic frameworks coating for facilitated offshore CO 2 fixation [J ] . ChemBioChem , 2023 , 24 ( 10 ): e202300114 .

张翀 , 邢新会 . 辅酶再生体系的研究进展 [J ] . 生物工程学报 , 2004 , 20 ( 6 ): 811 - 816 .

ZHANG C , XING X H . Research progress in cofactor regeneration systems [J ] . Chinese Journal of Biotechnology , 2004 , 20 ( 6 ): 811 - 816 .

LI Y , WEN L Y , TAN T W , et al . Sequential co-immobilization of enzymes in metal-organic frameworks for efficient biocatalytic conversion of adsorbed CO 2 to formate [J ] . Frontiers in Bioengineering and Biotechnology , 2019 , 7 : 394 .

REN S Z , WANG Z Y , BILAL M , et al . Co-immobilization multienzyme nanoreactor with co-factor regeneration for conversion of CO 2 [J ] . International Journal of Biological Macromolecules , 2020 , 155 : 110 - 118 .

CHEN Y J , LI P , ZHOU J W , et al . Integration of enzymes and photosensitizers in a hierarchical mesoporous metal-organic framework for light-driven CO 2 reduction [J ] . Journal of the American Chemical Society , 2020 , 142 ( 4 ): 1768 - 1773 .

LI Y , WANG J Q , SHI X Q , et al . Spatiotemporal encapsulation of tandem enzymes in hierarchical metal-organic frameworks for cofactor-dependent photoenzymatic CO 2 conversion [J ] . Advanced Science , 2024 , 11 ( 48 ): 2410024 .

ZHAO Z F , ZHENG D , GUO M L , et al . Engineering olefin-linked covalent organic frameworks for photoenzymatic reduction of CO 2 [J ] . Angewandte Chemie International Edition , 2022 , 61 ( 12 ): e202200261 .

CHEN Q , WANG Y J , LUO G S . Photoenzymatic CO 2 reduction dominated by collaborative matching of linkage and linker in covalent organic frameworks [J ] . Journal of the American Chemical Society , 2024 , 146 ( 1 ): 586 - 598 .

STANIASZEK Z , GRIFFITHS P T , FOLBERTH G A , et al . The role of future anthropogenic methane emissions in air quality and climate [J ] . npj Climate and Atmospheric Science , 2022 , 5 : 21 .

CONRADO R J , GONZALEZ R . Envisioning the bioconversion of methane to liquid fuels [J ] . Science , 2014 , 343 ( 6171 ): 621 - 623 .

LIAO J C , MI L , PONTRELLI S , et al . Fuelling the future: microbial engineering for the production of sustainable biofuels [J ] . Nature Reviews Microbiology , 2016 , 14 ( 5 ): 288 - 304 .

SAUNOIS M , JACKSON R B , BOUSQUET P , et al . The growing role of methane in anthropogenic climate change [J ] . Environmental Research Letters , 2016 , 11 ( 12 ): 120207 .

LUNDBERG D J , KIM J , TU Y M , et al . Concerted methane fixation at ambient temperature and pressure mediated by an alcohol oxidase and Fe-ZSM-5 catalytic couple [J ] . Nature Catalysis , 2024 , 7 ( 12 ): 1359 - 1371 .

WEI H , WANG E K . Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes [J ] . Chemical Society Reviews , 2013 , 42 ( 14 ): 6060 - 6093 .

GAO L Z , CHEN L , ZHANG R F , et al . Nanozymes: next-generation artificial enzymes [J ] . Scientia Sinica Chimica , 2022 , 52 ( 9 ): 1649 - 1663 .

GAO R , ZHONG N Y , HUANG S M , et al . Multienzyme biocatalytic cascade systems in porous organic frameworks for biosensing [J ] . Chemistry – a European Journal , 2022 , 28 ( 34 ): e202200074 .

ZHANG H , LI G L , LIAO C Y , et al . Bio-related applications of porous organic frameworks (POFs) [J ] . Journal of Materials Chemistry B , 2019 , 7 ( 15 ): 2398 - 2420 .

STANLEY P M , SU A Y , RAMM V , et al . Photocatalytic CO 2 -to-syngas evolution with molecular catalyst metal-organic framework nanozymes [J ] . Advanced Materials , 2023 , 35 ( 6 ): 2207380 .

GAO S Q , ZHAO X , ZHANG Q , et al . Mimic metalloenzymes with atomically dispersed Fe sites in covalent organic framework membranes for enhanced CO 2 photoreduction [J ] . Chemical Science , 2025 , 16 ( 3 ): 1222 - 1232 .

SUI J F , GAO M L , QIAN B , et al . Bioinspired microenvironment modulation of metal-organic framework-based catalysts for selective methane oxidation [J ] . Science Bulletin , 2023 , 68 ( 17 ): 1886 - 1893 .

BAEK J , RUNGTAWEEVORANIT B , PEI X K , et al . Bioinspired metal-organic framework catalysts for selective methane oxidation to methanol [J ] . Journal of the American Chemical Society , 2018 , 140 ( 51 ): 18208 - 18216 .

MAO X , GONG W B , FU Y , et al . Computational design and experimental validation of enzyme mimicking Cu-based metal-organic frameworks for the reduction of CO 2 into C 2 products: C—C coupling promoted by ligand modulation and the optimal Cu-Cu distance [J ] . Journal of the American Chemical Society , 2023 , 145 ( 39 ): 21442 - 21453 .

PARK W , CHA S , HAHN J S . Advancements in biological conversion of C 1 feedstocks: sustainable bioproduction and environmental solutions [J ] . ACS Synthetic Biology , 2024 , 13 ( 12 ): 3788 - 3798 .

ZHU Z , TIAN J , GENG P Y , et al . Chlamydomonas reinhardtii chloroplast factory construction for formate bioconversion [J ] . Bioresource Technology , 2024 , 401 : 130757 .

YANG Y W , LI M J , TAO W Q , et al . Study of carbon dioxide sequestration and electricity generation by a new hybrid bioenergy system with the novelty catalyst [J ] . Applied Thermal Engineering , 2021 , 197 : 117366 .

杜翠红 . 沼泽红假单胞菌RubisCO基因的克隆与表达及其固定二氧化碳特性的研究 [D ] . 大连 : 大连理工大学 , 2003 .

DU C H . Cloning and expression of RubisCO gene from Rhodopseudomonas palustris for CO 2 fixation [D ] . Dalian : Dalian University of Technology , 2003 .

YANG Y W , LI M J , HUNG T C . Enhancing CO 2 dissolution and inorganic carbon conversion by metal-organic frameworks improves microalgal growth and carbon fixation efficiency [J ] . Bioresource Technology , 2024 , 407 : 131113 .

XU J C , CHENG J , WANG Y L , et al . Strengthening CO 2 dissolution with zeolitic imidazolate framework-8 nanoparticles to improve microalgal growth in a horizontal tubular photobioreactor [J ] . Chemical Engineering Journal , 2021 , 405 : 126062 .

FLAIG R W , OSBORN POPP T M , FRACAROLI A M , et al . The chemistry of CO 2 capture in an amine-functionalized metal-organic framework under dry and humid conditions [J ] . Journal of the American Chemical Society , 2017 , 139 ( 35 ): 12125 - 12128 .

LI D Y , DONG H , CAO X P , et al . Enhancing photosynthetic CO 2 fixation by assembling metal-organic frameworks on Chlorella pyrenoidosa [J ] . Nature Communications , 2023 , 14 : 5337 .

JI Z , ZHANG H , LIU H , et al . Cytoprotective metal-organic frameworks for anaerobic bacteria [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2018 , 115 ( 42 ): 10582 - 10587 .

ZHENG D , ZHENG Y L , TAN J J , et al . Co-immobilization of whole cells and enzymes by covalent organic framework for biocatalysis process intensification [J ] . Nature Communications , 2024 , 15 : 5510 .

OEHLMANN N N , SCHMIDT F V , HERZOG M , et al . The iron nitrogenase reduces carbon dioxide to formate and methane under physiological conditions: a route to feedstock chemicals [J ] . Science Advances , 2024 , 10 ( 33 ): eado7729 .

FEDOROVA D , BEN-NISSAN R , MILSHTEIN E , et al . Demonstration of bioplastic production from CO 2 and formate using the reductive Glycine pathway in E . coli [J ] . PLoS One , 2025 , 20 ( 7 ): e0327512 .

GU Y M , QI H F , SUN T T , et al . Insights into the ultra-high volumetric capacity in a robust metal-organic framework for efficient C 2 H 2 /CO 2 separation [J ] . Chemistry of Materials , 2022 , 34 ( 6 ): 2708 - 2716 .

YIN Y , ZHANG Y , ZHOU X , et al . Ultrahigh-surface area covalent organic frameworks for methane adsorption [J ] . Science , 2024 , 386 ( 6722 ): 693 - 696 .

LI X S , ZHAO J , HOU S L , et al . Alkynol-supported new cascade strategy for eco-friendly conversion of CO 2 into 1,3-oxazinan-2-ones catalyzed by strong-acid/base-resistant metal-organic framework [J ] . CCS Chemistry , 2024 , 6 ( 12 ): 2982 - 2995 .

GUO Y Y , CHEN J W , PENG L , et al . Enhanced CO 2 photoconversion at elevated pressures using conductive polymer modified metal-organic framework [J ] . CCS Chemistry , 2024 , 6 ( 12 ): 2926 - 2939 .

HAO L Q , ZHU Q Q , QIAO X L , et al . Fast production of covalent organic frameworks for covalent enzyme immobilization with boosted enzymatic catalysis by solar-driven photothermal effect [J ] . Angewandte Chemie International Edition , 2025 , 64 ( 4 ): e202416550 .

YE J , WANG C , GAO C , et al . Solar-driven methanogenesis with ultrahigh selectivity by turning down H 2 production at biotic-abiotic interface [J ] . Nature Communications , 2022 , 13 : 6612 .

LIN J B , NGUYEN T T T , VAIDHYANATHAN R , et al . A scalable metal-organic framework as a durable physisorbent for carbon dioxide capture [J ] . Science , 2021 , 374 ( 6574 ): 1464 - 1469 .

WRIGHT A M , KAPELEWSKI M T , MARX S , et al . Transitioning metal-organic frameworks from the laboratory to market through applied research [J ] . Nature Materials , 2025 , 24 ( 2 ): 178 - 187 .

王孟锦 , 王洒 , 任红霞 , 等 . 共价有机框架材料: 一类新兴的均孔吸附分离树脂 [J ] . 科学通报 , 2024 , 69 ( 16 ): 2233 - 2245 .

WANG M J , WANG S , REN H X , et al . Covalent organic frameworks: an emerging class of resins with homopores [J ] . Chinese Science Bulletin , 2024 , 69 ( 16 ): 2233 - 2245 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Progress in hybrid systems of biological entities and materials for low-carbon biosynthesis

Applications of protein engineering in pharmaceutical industry

BioHPP®: a benchmark of biomanufacturing for high optically pure L-phosphinothricin

Chemoenzymatic synthesis of natural products: evolution of synthetic methodology and strategy

Recent development of directed evolution in protein engineering

Related Author

GUO Xinyi

GUO Shuqi

LI Shuwei

JIAO Ziyue

FEI Qiang

LIU Hedong

CAO Chunlai

WU Ruibo

Related Institution

Xi’an Key Laboratory of C1 Compound Bioconversion Technology

School of Chemical Engineering and Technology， Xi’an Jiaotong University

The United Biotechnology （Zhuhai Hengqin） Co.， Ltd.

Zhuhai United Laboratories Co.， Ltd

School of Pharmaceutical Science，Sun Yat-Sen University

⁰

Applications of functional framework materials in C1 biotransformation

DOI：10.12211/2096-8280.2025-003

摘要

Abstract

关键词

Keywords

references

Applications of functional framework materials in C₁ biotransformation