Progress in the development of instruments and processes and the commercialization of syngas fermentation

BAI Xue; LIANG Nan; LI Xinqi; MO Zhipeng; TONG Shuhuan; YUE Meiqi; JIA Xiaojing; REN Kang; XI Xiaojie; CHAO Wei

doi:10.12211/2096-8280.2025-001

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Progress in the development of instruments and processes and the commercialization of syngas fermentation

Invited Review | 更新时间：2026-07-03

- Progress in the development of instruments and processes and the commercialization of syngas fermentation
- Synthetic Biology Journal Vol. 7, Issue 3, Pages: 603-626(2026)
- 作者机构：
  
  1.北京首钢朗泽科技股份有限公司，北京 100043
  2.河北首朗新能源科技有限公司，河北唐山 063200
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2025-001
  CLC： Q815
- Received：02 January 2025，
  
  Revised：2025-02-21，
  
  Published：30 June 2026
- 稿件说明：
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白雪，梁楠，李欣启，莫志朋，佟淑环，岳美琪，贾晓静，任康，息晓杰，晁伟. 合成气发酵装备、工艺及商业化进展研究［J］. 合成生物学， 2026， 7（3）： 603-626

BAI Xue， LIANG Nan， LI Xinqi， MO Zhipeng， TONG Shuhuan， YUE Meiqi， JIA Xiaojing， REN Kang， XI Xiaojie， CHAO Wei. Progress in the development of instruments and processes and the commercialization of syngas fermentation［J］. Synthetic Biology Journal， 2026， 7（3）： 603-626
白雪，梁楠，李欣启，莫志朋，佟淑环，岳美琪，贾晓静，任康，息晓杰，晁伟. 合成气发酵装备、工艺及商业化进展研究［J］. 合成生物学， 2026， 7（3）： 603-626 DOI： 10.12211/2096-8280.2025-001.

BAI Xue， LIANG Nan， LI Xinqi， MO Zhipeng， TONG Shuhuan， YUE Meiqi， JIA Xiaojing， REN Kang， XI Xiaojie， CHAO Wei. Progress in the development of instruments and processes and the commercialization of syngas fermentation［J］. Synthetic Biology Journal， 2026， 7（3）： 603-626 DOI： 10.12211/2096-8280.2025-001.

摘要

在全球气候变暖日益加剧的背景下，探索并实施有效的碳减排策略，已成为应对这一全球性挑战的当务之急。合成气发酵技术作为一种减少温室气体排放、回收工业尾气并生产可再生燃料和化学品的绿色低碳技术，在全球气候缓解和循环经济转型中发挥着重要作用。工业菌种被认为是生物发酵的“芯片”，而在合成气发酵技术转化落地过程中，新装备、新工艺的开发同样重要。本文综述了在合成气发酵领域菌种端和工业应用端重要装备的研究进展，总结了包括原料气净化处理、气体发酵、产物分离提取等工艺在内的全流程合成气发酵集成技术的发展和面临的挑战，系统梳理了合成气发酵商业化项目的发展脉络，指出技术的工程转化与推广不仅要求技术上的革新突破，更需要前瞻的商业布局以及政策的支持，为合成气发酵技术的发展和商业化项目复制推广提供重要参考。

Abstract

In the context of the increasingly severe global warming

exploration and implementation of effective carbon reduction strategies have become an urgent priority to address this challenge. Syngas fermentation

as a green low-carbon technology that reduces greenhouse gas emissions

recycles industrial waste gas

and produces renewable fuels and chemicals

plays an important role in mitigating global warming for a circular economy. Industrial strains are “chips” of fermentation

but for transforming and implementing syngas fermentation technology

the development of new instruments and processes is also very important. In this article

we review the research progress on important instruments for the strain development and industrial applications of syngas fermentation. Firstly

we summarize the latest advances in high-throughput cultivation and screening of anaerobic microorganisms

which have accelerated the optimization and iteration of screening and engineering industrial strains for syngas fermentation

providing robust workhorses for commercial application. Then

the review outlines the research progress of various types of reactors that are currently used for syngas fermentation

including stirred tanks

bubble columns

gas-lift reactors

trickle bed reactors

and hollow fiber membrane reactors

and discusses their potentials and challenges in industrial productions. Among these reactors

the gas-lift reactor

due to its low energy consumption

simple structure for less maintenance

and good economic performance

has been widely used in the commercial application of syngas fermentation. Furthermore

we comment on the development and challenge faced by the integrated syngas fermentation process

including raw gas purification

gas fermentation

and product recovery. After an in-depth discussion of the development trajectory of commercialization projects for syngas fermentation

the review points out that the promotion of syngas fermentation not only requires technological breakthroughs

but also meticulous engineering management

forward-looking commercial planning

and strong policy support

all of which are critical for advancing the technology from the laboratory to the market.

关键词

Keywords

references

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