Recent advances in synthetic biology-intensified lipopeptide biosurfactants for environmental pollution remediation

ZHANG Yisang; SHANG Wei; DING Mingzhu; CHENG Jingsheng

doi:10.12211/2096-8280.2026-025

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Recent advances in synthetic biology-intensified lipopeptide biosurfactants for environmental pollution remediation

更新时间：2026-07-23

- Recent advances in synthetic biology-intensified lipopeptide biosurfactants for environmental pollution remediation
- 合成生物技术强化脂肽表面活性剂环境修复进展
- Synthetic Biology Journal Pages: 1-29(2026)
- 作者机构：
  
  1.合成生物技术全国重点实验室，天津　300350
  2.天津大学合成生物与生物制造学院，天津　300350
  3.物质绿色创造与制造海河实验室，天津　300192
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2026-025
  CLC： Q816
- Received：14 April 2026，
  
  Revised：2026-07-04，
  
  Online First：23 July 2026，
- 稿件说明：
移动端阅览
张亦桑，尚维，丁明珠，程景胜. 合成生物技术强化脂肽表面活性剂环境修复进展［J］. 合成生物学， 2026， 7. DOI： 10.12211/2096-8280.2026-025

ZHANG Yisang， SHANG Wei， DING Mingzhu， CHENG Jingsheng. Recent advances in synthetic biology-intensified lipopeptide biosurfactants for environmental pollution remediation［J］. Synthetic Biology Journal， 2026， 7. DOI： 10.12211/2096-8280.2026-025
张亦桑，尚维，丁明珠，程景胜. 合成生物技术强化脂肽表面活性剂环境修复进展［J］. 合成生物学， 2026， 7. DOI： 10.12211/2096-8280.2026-025 DOI：

ZHANG Yisang， SHANG Wei， DING Mingzhu， CHENG Jingsheng. Recent advances in synthetic biology-intensified lipopeptide biosurfactants for environmental pollution remediation［J］. Synthetic Biology Journal， 2026， 7. DOI： 10.12211/2096-8280.2026-025 DOI：

摘要

污染场地中疏水有机物、重金属及新污染物的去除常受界面传质、强吸附和群落稳定性限制，单纯增强降解代谢难以保证场地效果。脂肽类生物表面活性剂兼具高界面活性、低环境负荷和非核糖体肽合成酶（NRPS）介导的结构可编程性，是连接污染物分配、细胞行为和工程部署的关键界面功能模块。本文以“从外源添加剂到可编程界面模块”为主线，综述脂肽结构—功能关系、NRPS装配逻辑、底盘细胞重塑与混菌构建策略，以及在石油烃、重金属、抗生素和农药污染修复中的应用。现有进展表明，脂肽研究的核心已由简单提高溶解度，推进到三类可工程化问题：一是通过调节脂肪酸链长、肽环组成和同系物分布控制临界胶束浓度（CMC）、乳化和络合性能；二是通过原位生成和合成菌群设计同步改善传质、定殖和群落分工；三是通过低劣生物质（如厨余、农业废弃物和工业副产物）供给与泡沫分馏、过程放大及生物安全控制耦合，提升场地部署可行性。未来需围绕可编程脂肽库、数据驱动DBTL循环、场景化剂量窗口和开放环境生物封存建立标准化评价体系，推动脂肽由经验性修复增效因子转化为环境合成生物学中的可设计、可预测和可控制模块。

Abstract

Pollutant removal in soils

sediments

and wastewater is often constrained by interfacial mass transfer

strong sorption

limited contaminant bioavailability

and instability of introduced microbial functions under open environmental conditions. Lipopeptide biosurfactants offer a distinctive route to address these constraints because they combine strong interfacial activity

biodegradability

relatively low environmental burden

and nonribosomal peptide synthetase (NRPS)-encoded structural programmability. Given the interfacial mass-transfer limitations in pollutant remediation and the design requirements of environmental synthetic biology

this review reframes lipopeptides not merely as exogenous surfactant additives

but as programmable interfacial functional modules that connect contaminant partitioning

microbial adhesion

community organization

and field deployment. We summarize the structural features and NRPS assembly logic of representative lipopeptide families

discuss chassis engineering

metabolic regulation

mixed-culture production

low-grade biomass valorization

and evaluate application evidence in the pollution remediation of petroleum hydrocarbons

heavy metals

antibiotics

and pesticides. Current progress indicates that the central advances in this field have moved beyond the simple enhancement of contaminant solubility. First

fatty-acid chain length

peptide-ring composition

and homologue distribution can be engineered to tune critical micelle concentration

emulsification

adsorption

membrane interaction

and metal-complexation behavior. Second

in situ lipopeptide generation and synthetic microbial consortia can couple interfacial mass transfer with colonization

division of labor

and community persistence. Third

integration with low-grade biomass feedstocks

foam-based in situ recovery

process scale-up

and biosafety control provides a more realistic route toward deployable remediation systems. This perspective also clarifies why lipopeptide performance must be interpreted through the joint effects of molecular structure

phase behavior

microbial physiology

and site heterogeneity rather than by surface tension alone. We further analyze dose-window effects

micellar sequestration

membrane stress

chassis compatibility

foam management

downstream recovery

regulatory constraints

and genetic biocontainment as key boundaries for translation. Future research should establish programmable lipopeptide libraries

standardized interfacial phenotyping

data-driven Design-Build-Test-Learn cycles

scenario-specific dose windows

and biosafety-by-design strategies. Such developments would enable lipopeptides to evolve from empirical remediation enhancers into designable

predictable

and controllable modules within environmental synthetic biology.

关键词

Keywords

references

SHARMA A K , SHARMA M , SHARMA A K , et al . Mapping the impact of environmental pollutants on human health and environment: a systematic review and meta-analysis [J ] . Journal of Geochemical Exploration , 2023 , 255 : 107325 .

AWEWOMOM J , DZEBLE F , TAKYI Y D , et al . Addressing global environmental pollution using environmental control techniques: a focus on environmental policy and preventive environmental management [J ] . Discover Environment , 2024 , 2 ( 1 ): 8 .

MONIRUZZAMAN . Why environmental pollution remains unresolved despite efforts to mitigate it? [J ] . DIROSAT: Journal of Education , Social Sciences & Humanities, 2025 , 3 ( 2 ): 136 - 148 .

SINGH N , HU X H , KUMAR V , et al . Microbially derived surfactants: an ecofriendly, innovative, and effective approach for managing environmental contaminants [J ] . Frontiers in Bioengineering and Biotechnology , 2024 , 12 .

SELVA FILHO A A P , CONVERTI A , SOARES DA SILVA R de C F , et al . Biosurfactants as multifunctional remediation agents of environmental pollutants generated by the petroleum industry [J ] . Energies , 2023 , 16 ( 3 ): 1209 .

ZHOU H , LIU Q , JIANG L , et al . Enhanced remediation of oil-contaminated intertidal sediment by bacterial consortium of petroleum degraders and biosurfactant producers [J ] . Chemosphere , 2023 , 330 : 138763 .

SINGHA L P , KUMARI R , SINGHA K M , et al . Synergistic co-metabolism enhancing the crude oil degradation by acinetobacter oleivorans DR1 and its metabolic potential [J ] . Microbiology Spectrum , 2025 , 13 ( 7 ): e03023-24 .

PHULPOTO I A , QI Z , QAZI M A , et al . Biosurfactants-based mixed polycyclic aromatic hydrocarbon degradation: from microbial community structure toward non-targeted metabolomic profile determination [J ] . Environment International , 2024 , 184 : 108448 .

LEA-SMITH D J , HASSARD F , COULON F , et al . Engineering biology applications for environmental solutions: potential and challenges [J ] . Nature Communications , 2025 , 16 ( 1 ): 3538 .

JAISWAL S , SHUKLA P . Alternative strategies for microbial remediation of pollutants via synthetic biology [J ] . Frontiers in Microbiology , 2020 , 11 .

YAASHIKAA P R , DEVI M K , KUMAR P S . Engineering microbes for enhancing the degradation of environmental pollutants: a detailed review on synthetic biology [J ] . Environmental Research , 2022 , 214 : 113868 .

LI J Y , WANG L , LIU Y F , et al . Microbial lipopeptide-producing strains and their metabolic roles under anaerobic conditions [J ] . Microorganisms , 2021 , 9 ( 10 ): 2030 .

MNIF I , GHRIBI D . Review lipopeptides biosurfactants: mean classes and new insights for industrial, biomedical, and environmental applications [J ] . Peptide Science , 2015 , 104 ( 3 ): 129 - 147 .

IBRAR M , ZHANG H . Construction of a hydrocarbon-degrading consortium and characterization of two new lipopeptides biosurfactants [J ] . Science of the Total Environment , 2020 , 714 : 136400 .

LOZANO-ANDRADE C N , DINESEN C , WIBOWO M , et al . Surfactin facilitates establishment of bacillus subtilis in synthetic communities [J ] . The ISME Journal , 2025 , 19 ( 1 ): wraf013 .

HABIB S , AHMAD S A , WAN JOHARI W L , et al . Production of lipopeptide biosurfactant by a hydrocarbon-degrading antarctic rhodococcus [J ] . International Journal of Molecular Sciences , 2020 , 21 ( 17 ): 6138 .

PACWA-PŁOCINICZAK M , PŁAZA G A , PIOTROWSKA-SEGET Z , et al . Environmental applications of biosurfactants: recent advances [J ] . International Journal of Molecular Sciences , 2011 , 12 ( 1 ): 633 - 654 .

SHETTY S S , D D , S H , et al . Environmental pollutants and their effects on human health [J ] . Heliyon , 2023 , 9 ( 9 ): e19496 .

CHEN C , LI K , LIN X , et al . Engineering natural microbial communities: harnessing synthetic communities for bioremediation [J ] . Current Opinion in Microbiology , 2025 , 87 : 102652 .

LI S , JIANG X , ZHAO C , et al . Evaluation of lipopeptides biosurfactant from raoultella planticola for bioremediation in n-hexadecane-contaminated soil [J ] . Journal of Environmental Chemical Engineering , 2024 , 12 ( 3 ): 112622 .

CHEN X , JI Q , KONG J , et al . HOCs bioavailability response to soil aging: focusing on the indirect effects of aging conditions, environmental factors, and carrier-mediated changes in soil properties - a review [J ] . Emerging Contaminants , 2025 , 11 ( 4 ): 100566 .

LIN Z , ZOU X , ZHANG R , et al . Development and environmental implication of pedotransfer functions of Cd desorption rate coefficients in historically polluted soils [J ] . Environmental Pollution , 2020 , 257 : 113602 .

MISHRA S , LIN Z , PANG S , et al . Biosurfactant is a powerful tool for the bioremediation of heavy metals from contaminated soils [J ] . Journal of Hazardous Materials , 2021 , 418 : 126253 .

BOSE S , SENTHIL KUMAR P , RANGASAMY G . Exploring the role of biosurfactants in the remediation of organic contaminants with a focus on the mechanism- a review [J ] . Journal of Molecular Liquids , 2024 , 393 : 123585 .

JI X , WANG Y , GUO Z , et al . Synthetic bacterial community based on microbial interactions for bioremediation of petroleum contaminated sites [J ] . Journal of Environmental Sciences , 2026 , 161 : 536 - 544 .

ZHANG Y , GILBERT J A , LIU X , et al . SynCom-mediated herbicide degradation activates microbial carbon metabolism in soils [J ] . iMeta , 2025 , 4 ( 5 ): e70058 .

CUI J , DÖRMANN P . Microbial degradation of hydrocarbons from petroleum assisted by biosurfactants: pathways and bioremediation potential [J ] . Biochimie , 2025 , 239 : 103 - 119 .

ZHU S , LI M , QIAN T , et al . Influence of surfactants on interfacial microbial degradation of hydrophobic organic compounds [J ] . Catalysts , 2025 , 15 ( 2 ).

ALCÁNTARA M T , GÓMEZ J , PAZOS M , et al . Electrokinetic remediation of lead and phenanthrene polluted soils [J ] . Geoderma , 2012 , 173-174 : 128 - 133 .

PHULPOTO I A , YU Z , QAZI M A , et al . A comprehensive study on microbial-surfactants from bioproduction scale-up toward electrokinetics remediation of environmental pollutants: challenges and perspectives [J ] . Chemosphere , 2023 , 311 : 136979 .

GARCIA-BLAS N , JIMENEZ-RELINQUE E , CASTELLOTE M . Surfactants in electrokinetic remediation of sediments to enhance the removal of metals [J ] . Journal of Soils and Sediments , 2022 , 22 ( 11 ): 2853 - 2864 .

THAPA B S , PANDIT S , MISHRA R K , et al . Emergence of per- and poly-fluoroalkyl substances (PFAS) and advances in the remediation strategies [J ] . Science of the Total Environment , 2024 , 916 : 170142 .

AMEN R , IBRAHIM A , SHAFQAT W , et al . A critical review on PFAS removal from water: removal mechanism and future challenges [J ] . Sustainability , 2023 , 15 ( 23 ).

THAKUR A , KHUSNUTDINOVA A N , NAVARRO-MÁRQUEZ M , et al . Comprehensive strategies for the remediation of per- and polyfluoroalkyl substances (PFAS): mechanisms, technologies, and future perspectives [J ] . Ecotoxicology and Environmental Safety , 2025 , 306 : 119374 .

NAPOLI R , FAZZINO F , VAGLIASINDI F G A , et al . Sustainable remediation strategies and technologies of per- and polyfluoroalkyl substances (PFAS)-contaminated soils: a critical review [J ] . Sustainability , 2025 , 17 ( 14 ): 6635 .

DELL'ARMI E , CIAMPI P , MARCHETTI A , et al . Field test of a scaled-up bioelectrochemical sequential reductive/oxidative process for chlorinated aliphatic hydrocarbons (CAHs) remediation from contaminated groundwater [J ] . Chemical Engineering Journal , 2025 , 524 : 169825 .

GHANDEHARI S S , VAN BENSCHOTEN I , ARCELLANA P D , et al . Use of upcycled biosolids for bioremediation of groundwater contaminated with chlorinated solvents [J ] . Environmental Science and Pollution Research International , 2026 , 33 ( 2 ): 526 - 539 .

HOSSEINI S , SHARIFI R , HABIBI A . Efficient bioremediation of crude oil contaminated soil by a consortium of in-situ biosurfactant producing hydrocarbon-degraders [J ] . Scientific Reports , 2025 , 15 ( 1 ): 19852 .

WANG X , HOU J , LING H , et al . Enhancing petroleum hydrocarbon degradation by a synthetic bacterial consortium: insights into functional complementarity and regulatory coordination [J ] . Chemical Engineering Journal , 2026 , 527 : 171992 .

ELUMALAI P , RAJAMOHAN R , THASHBIN VAYAL PURAYIL A , et al . Biosurfactant and iron oxide nanoparticle-assisted bioremediation of soil co-contaminated with hydrocarbons and hazardous heavy metals [J ] . Chemical Engineering Journal , 2024 , 497 : 154677 .

MA X . Heavy metals remediation through lactic acid bacteria: current status and future prospects [J ] . Science of the Total Environment , 2024 , 946 : 174455 .

SU C , CUI H , WANG W , et al . Bioremediation of complex organic pollutants by engineered vibrio natriegens [J ] . Nature , 2025 , 642 ( 8069 ): 1024 - 1033 .

HELVIG C , KARIYAWASAM T , VRIENS B , et al . Genetically engineered bacteria and microalgae expressing a mutant of cytochrome P450 BM3 for efficient diuron degradation in wastewater treatment [J ] . Microbiology Spectrum , 2025 , 13 ( 6 ): e02905-24 .

REN H , QIN M , ZHANG L , et al . Modular engineering of a synthetic biology-based platform for sustainable bioremediation of residual antibiotics in aquatic environments [J ] . Engineering , 2025 , 53 : 231 - 244 .

LIU H , ZHANG L , WANG W , et al . An intelligent synthetic bacterium for chronological toxicant detection, biodegradation, and its subsequent suicide [J ] . Advanced Science , 2023 , 10 ( 31 ): 2304318 .

HUANG Y , HU J , ZHENG J , et al . A review of microbial degradation of perfluorinated and polyfluoroalkyl substances (PFAS) during waste biotransformation processes: influencing factors and alleviation measures [J ] . Environmental Research , 2025 , 279 : 121795 .

LIN J , YE W , XIE M , et al . Environmental impacts and remediation of dye-containing wastewater [J ] . Nature Reviews Earth & Environment , 2023 , 4 ( 11 ): 785 - 803 .

RANE A N , BAIKAR V V , RAVI KUMAR V , et al . Agro-industrial wastes for production of biosurfactant by bacillus subtilis ANR 88 and its application in synthesis of silver and gold nanoparticles [J ] . Frontiers in Microbiology , 2017 , 8 .

GUZMÁN E , ORTEGA F , RUBIO R G . Exploring the world of rhamnolipids: a critical review of their production, interfacial properties, and potential application [J ] . Current Opinion in Colloid & Interface Science , 2024 , 69 : 101780 .

XIE Z , LIU S . Interface mechanism of promoting low-rank coal flotation by characteristic groups in hydrophilic moieties of cationic–anionic surfactants [J ] . Langmuir , 2025 , 41 ( 2 ): 1502 - 1518 .

RAHEJA Y , SHARMA P , GAUR P , et al . Advancing bioremediation: biosurfactants as catalysts for sustainable remediation [J ] . Biodegradation , 2025 , 36 ( 3 ): 33 .

HE L , LI O , QIN J , et al . Effects of mono- and multicomponent nonaqueous-phase liquid on the migration and retention of pollutant-degrading bacteria in porous media [J ] . Water Research , 2025 , 268 : 122673 .

Preethi , SHANMUGAVEL S P , KUMAR G , et al . Recent progress in mineralization of emerging contaminants by advanced oxidation process: A review [J ] . Environmental Pollution , 2024 , 341 : 122842 .

DUOANDICOECHEA U , BILBAO-GARCÍA E , VILLOTA N . Kinetic modeling of sulfamethoxazole degradation by photo-fenton: tracking color development and iron complex formation for enhanced bioremediation [J ] . Applied Sciences , 2025 , 15 ( 8 ): 4531 .

DENG S , WANG B , ZHANG H , et al . Degradation and enhanced oil recovery potential of alcanivorax borkumensis through production of bio-enzyme and bio-surfactant [J ] . Bioresource Technology , 2024 , 400 : 130690 .

TONG W K , DAI C , HU J , et al . A novel eco-friendly strategy for removing phenanthrene from groundwater: synergism of nanobubbles and rhamnolipid [J ] . Science of the Total Environment , 2024 , 907 : 168099 .

BEZZA F A , NKHALAMBAYAUSI CHIRWA E M . Biosurfactant-enhanced bioremediation of aged polycyclic aromatic hydrocarbons (PAHs) in creosote contaminated soil [J ] . Chemosphere , 2016 , 144 : 635 - 644 .

ZHANG H , ZHANG W , ZONG Y , et al . Dynamics of microbial-induced oil degradation at the microscale [J ] . Microbiology Spectrum , 2024 , 12 ( 12 ): e01176-24 .

PRASAD M , OBANA N , LIN S Z , et al . Alcanivorax borkumensis biofilms enhance oil degradation by interfacial tubulation [J ] . Science , 2023 , 381 ( 6659 ): 748 - 753 .

WANG Z , WANG S , HE Q , et al . Ecological design of high-performance synthetic microbial communities: from theoretical foundations to functional optimization [J ] . ISME Communications , 2025 , 5 ( 1 ): ycaf133 .

ZHAI Y , MA J , GAO G , et al . Enhancing phenanthrene degradation by burkholderia sp. FM-2 with rhamnolipid: mechanistic insights from cell surface properties and transcriptomic analysis [J ] . Microorganisms , 2025 , 13 ( 11 ): 2608 .

LAHA S , LUTHY R G . Inhibition of phenanthrene mineralization by nonionic surfactants in soil-water systems [J ] . Environmental Science & Technology , 1991 , 25 ( 11 ): 1920 - 1930 .

MORA A K , SINGH P K , NATH S . Controlled Sequestration of DNA Intercalated Drug by Polymer–Surfactant Supramolecular Assemblies [J ] . The Journal of Physical Chemistry B , 2016 , 120 ( 17 ): 4143 - 4151 .

MAKKAR R S , ROCKNE K J . Comparison of synthetic surfactants and biosurfactants in enhancing biodegradation of polycyclic aromatic hydrocarbons [J ] . Environmental Toxicology and Chemistry , 2003 , 22 ( 10 ): 2280 - 2292 .

SIKANDAR S , JAMAL A , MANSOOR A , et al . Deciphering supramolecular arrangements, micellization patterns, and antimicrobial potential of bacterial rhamnolipids under extreme treatments of temperature and electrolyte [J ] . Frontiers in Microbiology , 2024 , 15 .

MANASA B , PATRO L , BHARGAVA B L . Interactions of surfactin with ether-linked and ester-linked lipid membranes: a molecular dynamics simulation study [J ] . Biophysical Chemistry , 2026 , 330 : 107567 .

THAKUR V , BAGHMARE P , VERMA A , et al . Recent progress in microbial biosurfactants production strategies: applications, technological bottlenecks, and future outlook [J ] . Bioresource Technology , 2024 , 408 : 131211 .

SREEDHARAN S M , RISHI N , SINGH R . Microbial lipopeptides: properties, mechanics and engineering for novel lipopeptides [J ] . Microbiological Research , 2023 , 271 : 127363 .

AOKI R , KUMAGAWA E , KAMATA K , et al . Engineering of acyl ligase domain in non-ribosomal peptide synthetases to change fatty acid moieties of lipopeptides [J ] . Communications Chemistry , 2025 , 8 ( 1 ): 17 .

WANG Z , LIU C , SHI Y , et al . Classification, application, multifarious activities and production improvement of lipopeptides produced by bacillus [J ] . Critical Reviews in Food Science and Nutrition , 2024 , 64 ( 21 ): 7451 - 7464 .

RABBEE M F , BAEK K H . Antimicrobial Activities of Lipopeptides and Polyketides of Bacillus velezensis for Agricultural Applications [J ] . Molecules , 2020 , 25 ( 21 ).

MÜNSSINGER S , BECK A , ORABY A , et al . Past, present and future of glycolipids from Ustilaginaceae – A review on cellobiose lipids and mannosylerythritol lipids [J ] . Journal of Surfactants and Detergents , 2024 , 27 ( 5 ): 647 - 689 .

YANG R , LEI S , XU X , et al . Key elements and regulation strategies of NRPSs for biosynthesis of lipopeptides by bacillus [J ] . Applied Microbiology and Biotechnology , 2020 , 104 ( 19 ): 8077 - 8087 .

ZHANG M , PENG Z , HUANG Z , et al . Functional diversity and engineering of the adenylation domains in nonribosomal peptide synthetases [J ] . Marine Drugs , 2024 , 22 ( 8 ).

IZORÉ T , CRYLE M J . The many faces and important roles of protein–protein interactions during non-ribosomal peptide synthesis [J ] . Natural Product Reports , 2018 , 35 ( 11 ): 1120 - 1139 .

HUANG Z , PENG Z , ZHANG M , et al . Structure, function and engineering of the nonribosomal peptide synthetase condensation domain [J ] . International Journal of Molecular Sciences , 2024 , 25 ( 21 ).

BLOUDOFF K , SCHMEING T M . Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity [J ] . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics , 2017 , 1865 ( 11, Part B): 1587-1604.

REIMER J M , HAQUE A S , TARRY M J , et al . Piecing together nonribosomal peptide synthesis [J ] . Current Opinion in Structural Biology , 2018 , 49 : 104 - 113 .

侯正杰 , 孙慧中 , 白松 , 等 . 环脂肽生物合成的研究进展 [J ] . 合成生物学 , 2021 , 2 ( 4 ): 577 - 597 .

HOU Z J , SUN H Z , BAI S , et al . Research progress of cyclic lipopeptide biosynthesis [J ] . Synthetic Biology Journal , 2021 , 2 ( 4 ): 577 - 597 .

ZHONG L , DIAO X , ZHANG N , et al . Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis [J ] . Nature Communications , 2021 , 12 ( 1 ): 296 .

GAO L , MA W , LU Z , et al . Translocation of subunit PPSE in plipastatin synthase and synthesis of novel lipopeptides [J ] . Synthetic and Systems Biotechnology , 2022 , 7 ( 4 ): 1173 - 1180 .

THONG W L , ZHANG Y , ZHUO Y , et al . Gene editing enables rapid engineering of complex antibiotic assembly lines [J ] . Nature Communications , 2021 , 12 ( 1 ): 6872 .

GAO L , GUO J , FAN Y , et al . Module and individual domain deletions of NRPS to produce plipastatin derivatives in bacillus subtilis [J ] . Microbial Cell Factories , 2018 , 17 ( 1 ): 84 .

Research on the regulation of plipastatin production by the quorum-sensing ComQXPA system of bacillus amyloliquefaciens [J ] . Journal of Agricultural and Food Chemistry , 2023 .

WANG S , WANG R , ZHAO X , et al . Systemically engineering bacillus amyloliquefaciens for increasing its antifungal activity and green antifungal lipopeptides production [J ] . Frontiers in Bioengineering and Biotechnology , 2022 , 10 .

TREINEN C , BIERMANN L , VAHIDINASAB M , et al . Deletion of Rap-phosphatases for quorum sensing control in Bacillus and its effect on surfactin production [J ] . AMB Express , 2023 , 13 ( 1 ): 51 .

WANG J , PING Y , LIU W , et al . Improvement of lipopeptide production in bacillus subtilis HNDF2-3 by overexpression of the sfp and comA genes [J ] . Preparative Biochemistry & Biotechnology , 2024 , 54 ( 2 ): 184 - 192 .

LILGE L , VAHIDINASAB M , ADIEK I , et al . Expression of degQ gene and its effect on lipopeptide production as well as formation of secretory proteases in bacillus subtilis strains [J ] . MicrobiologyOpen , 2021 , 10 ( 5 ): e1241 .

WANG M , ZHENG J , SUN S , et al . An integrated pipeline and overexpression of a novel efflux transporter, YoeA, significantly increases plipastatin production in bacillus subtilis [J ] . Foods , 2024 , 13 ( 11 ).

GAO G R , HOU Z J , DING M Z , et al . Improved production of fengycin in bacillus subtilis by integrated strain engineering strategy [J ] . ACS Synthetic Biology , 2022 , 11 ( 12 ): 4065 - 4076 .

CAROLIN C F , KUMAR P S , NGUEAGNI P T . A review on new aspects of lipopeptide biosurfactant: types, production, properties and its application in the bioremediation process [J ] . Journal of Hazardous Materials , 2021 , 407 : 124827 .

ZHU Z , ZHANG B , CAI Q , et al . A critical review on the environmental application of lipopeptide micelles [J ] . Bioresource Technology , 2021 , 339 : 125602 .

WANG S , BERGMAN M T , HALL C K , et al . De novo design of multiple microplastic-binding peptides with a protein language model-guided generative adversarial network [J ] . Journal of Chemical Information and Modeling , 2025 , 65 ( 16 ): 8527 - 8537 .

JAIN V , BERGMAN M T , HALL C K , et al . AI-driven rational design of promiscuous and selective plastic-binding peptides [J ] . Chemical Science , 2025 , 16 ( 44 ): 20823 - 20832 .

LIANG J , YANG F , DING Y , et al . Batch fermentation kinetics study of biosynthesis lipopeptides by Bacillus altitudinis Q7 in 5 L fermenter [J ] . Process Biochemistry , 2024 , 140 : 96 - 107 .

BINIARZ P , COUTTE F , GANCEL F , et al . High-throughput optimization of medium components and culture conditions for the efficient production of a lipopeptide pseudofactin by pseudomonas fluorescens BD5 [J ] . Microbial Cell Factories , 2018 , 17 ( 1 ): 121 .

COUTTE F , LECOUTURIER D , DIMITROV K , et al . Microbial lipopeptide production and purification bioprocesses, current progress and future challenges [J ] . Biotechnology Journal , 2017 , 12 ( 7 ): 1600566 .

ZHI Y , WU Q , XU Y . Genome and transcriptome analysis of surfactin biosynthesis in bacillus amyloliquefaciens MT45 [J ] . Scientific Reports , 2017 , 7 ( 1 ): 40976 .

JIAO S , LI X , YU H , et al . In situ enhancement of surfactin biosynthesis in Bacillus subtilis using novel artificial inducible promoters [J ] . Biotechnology and Bioengineering , 2017 , 114 ( 4 ): 832 - 842 .

WU Q , ZHI Y , XU Y . Systematically engineering the biosynthesis of a green biosurfactant surfactin by bacillus subtilis 168 [J ] . Metabolic Engineering , 2019 , 52 : 87 - 97 .

HOU Z J , LAI H M , CAO C Y , et al . Targeted knockout and plasmid-based transfer of NRPS/PKS for improving lipopeptide iturin A synthesis [J ] . International Journal of Biological Macromolecules , 2025 , 302 : 140610 .

ZHENG W , WANG X , ZHOU H , et al . Establishment of recombineering genome editing system in paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters [J ] . Microbial Biotechnology , 2020 , 13 ( 2 ): 397 - 405 .

XIA T Y , CHEN X A , LIU Y Q , et al . Redirection of acyl donor metabolic flux for lipopeptide A40926B0 biosynthesis [J ] . Microbial Biotechnology , 2022 , 15 ( 6 ): 1852 - 1866 .

ÖKTEM M , NGUYEN T H , BOSMAN E D C , et al . Lipopeptide-mediated delivery of CRISPR/Cas9 ribonucleoprotein complexes for gene editing and correction [J ] . Journal of Controlled Release , 2025 , 383 : 113854 .

ZHI Y , WU Q , XU Y . Production of surfactin from waste distillers' grains by co-culture fermentation of two Bacillus amyloliquefaciens strains [J ] . Bioresource Technology , 2017 , 235 : 96 - 103 .

WANG M , YU H , SHEN Z . Antisense RNA-based strategy for enhancing surfactin production in bacillus subtilis TS1726 via overexpression of the unconventional biotin carboxylase II to enhance ACCase activity [J ] . ACS Synthetic Biology , 2019 , 8 ( 2 ): 251 - 256 .

GAO L , SHE M , SHI J , et al . Enhanced production of iturin a by strengthening fatty acid synthesis modules in bacillus amyloliquefaciens [J ] . Frontiers in Bioengineering and Biotechnology , 2022 , 10 .

SHE M , ZHOU H , DONG W , et al . Modular metabolic engineering of bacillus amyloliquefaciens for high-level production of green biosurfactant iturin a [J ] . Applied Microbiology and Biotechnology , 2024 , 108 ( 1 ): 311 .

HE J X , HOU Z J , QIAO B , et al . Integration of engineering microbial consortium and boosting extracellular amylase of B. amyloliquefaciens for intensifying bioconversion of food waste into lipopeptides [J ] . Journal of Environmental Chemical Engineering , 2024 , 12 ( 4 ): 113161 .

QIN W Q , LIU Y F , GANG H Z , et al . Structural diversity of surfactin lipopeptides and their molecular behaviors in solutions and at interfaces [J ] . Advances in Colloid and Interface Science , 2025 , 343 : 103581 .

SUN H Z , CHEN X Y , ZHANG Y M , et al . Construction of multi-strain microbial consortia producing amylase, serine and proline for enhanced bioconversion of food waste into lipopeptides [J ] . Biochemical Engineering Journal , 2022 , 188 : 108682 .

CHEN X Y , SUN H Z , QIAO B , et al . Improved the lipopeptide production of bacillus amyloliquefaciens HM618 under co-culture with the recombinant corynebacterium glutamicum producing high-level proline [J ] . Bioresource Technology , 2022 , 349 : 126863 .

BAI S , QIAO B , HOU Z J , et al . Mutualistic microbial community of bacillus amyloliquefaciens and recombinant yarrowia lipolytica co-produced lipopeptides and fatty acids from food waste [J ] . Chemosphere , 2023 , 310 : 136864 .

ZHANG Y M , QIAO B , SHANG W , et al . Improving salt-tolerant artificial consortium of bacillus amyloliquefaciens for bioconverting food waste to lipopeptides [J ] . Waste Management , 2024 , 181 : 89 - 100 .

DUAN T X , SONG K G , SUN H Z , et al . Intensifying bioconversion of rich-capsaicinoids food waste into fengycin by the tolerant-artificial consortium [J ] . Chemical Engineering Journal , 2025 , 505 : 159389 .

LIU C X , XU Q M , YU S C , et al . Bio-removal of tetracycline antibiotics under the consortium with probiotics bacillus clausii T and bacillus amyloliquefaciens producing biosurfactants [J ] . Science of The Total Environment , 2020 , 710 : 136329 .

KHONDEE N , SUKSOMBOON B , KHUN-ARWUT N , et al . Scaled-up production and recovery of lipopeptide biosurfactant and its application for washing petroleum-contaminated drill cuttings [J ] . Journal of Environmental Chemical Engineering , 2024 , 12 ( 6 ): 114605 .

RAVINDRAN A , SAJAYAN A , PRIYADHARSHINI G B , et al . Revealing the efficacy of thermostable biosurfactant in heavy metal bioremediation and surface treatment in vegetables [J ] . Frontiers in Microbiology , 2020 , 11 : 222 .

ZHU Z , ZHANG B , CAI Q , et al . Fish waste based lipopeptide production and the potential application as a bio-dispersant for oil spill control [J ] . Frontiers in Bioengineering and Biotechnology , 2020 , 8 .

MULLIGAN C N . Sustainable remediation of contaminated soil using biosurfactants [J ] . Frontiers in Bioengineering and Biotechnology , 2021 , 9 .

ERAS-MUÑOZ E , FARRÉ A , SÁNCHEZ A , et al . Microbial biosurfactants: a review of recent environmental applications [J ] . Bioengineered , 2022 , 13 ( 5 ): 12365 - 12391 .

SAH D , RAI J P N , GHOSH A , et al . A review on biosurfactant producing bacteria for remediation of petroleum contaminated soils [J ] . 3 Biotech , 2022 , 12 ( 9 ): 218 .

GEORGE D R , DANCIU M , DAVENPORT P W , et al . A bumpy road ahead for genetic biocontainment [J ] . Nature Communications , 2024 , 15 ( 1 ): 650 .

CHEMLA Y , SWEENEY C J , WOZNIAK C A , et al . Design and regulation of engineered bacteria for environmental release [J ] . Nature Microbiology , 2025 , 10 ( 2 ): 281 - 300 .

SCHWAB A P . Bioremediation of polyaromatic hydrocarbons in soils: a review of recent progress [J ] . Current Pollution Reports , 2024 , 10 ( 4 ): 711 - 721 .

ŁAWNICZAK Ł , WOŹNIAK-KARCZEWSKA M , LOIBNER A P , et al . Microbial degradation of hydrocarbons—basic principles for bioremediation: a review [J ] . Molecules , 2020 , 25 ( 4 ).

PATOWARY K , PATOWARY R , KALITA M C , et al . Characterization of biosurfactant produced during degradation of hydrocarbons using crude oil As sole source of carbon [J ] . Frontiers in Microbiology , 2017 , 8 .

ZHAO F , CUI Q , SU H , et al . Biosurfactants are green and versatile enhancers for sustainable treatment of oily sludge: a review [J ] . Journal of Environmental Chemical Engineering , 2025 , 13 ( 1 ): 115087 .

HU F , WANG P , LI Y , et al . Bioremediation of environmental organic pollutants by Pseudomonas aeruginosa : Mechanisms, methods and challenges [J ] . Environmental Research , 2023 , 239 : 117211 .

WANG X T , LIU B , LI X Z , et al . Biosurfactants produced by novel facultative-halophilic bacillus sp. XT-2 with biodegradation of long chain n-alkane and the application for enhancing waxy oil recovery [J ] . Energy , 2022 , 240 : 122802 .

BEZZA F A , CHIRWA E M N . Production and applications of lipopeptide biosurfactant for bioremediation and oil recovery by Bacillus subtilis CN2 [J ] . Biochemical Engineering Journal , 2015 , 101 : 168 - 178 .

DAS S , DAS N , CHOURE K , et al . Biodegradation of asphaltene by lipopeptide-biosurfactant producing hydrocarbonoclastic, crude oil degrading Bacillus spp [J ] . Bioresource Technology , 2023 , 382 : 129198 .

PHULPOTO I A , YU Z , HU B , et al . Production and characterization of surfactin-like biosurfactant produced by novel strain bacillus nealsonii S2MT and it's potential for oil contaminated soil remediation [J ] . Microbial Cell Factories , 2020 , 19 ( 1 ): 145 .

Bioremediation of polycyclic aromatic hydrocarbon contaminated soil by a microbial consortium through supplementatio n of biosurfactant produced by pseudomonas aeruginosa strain [J ] . Polycyclic Aromatic Compounds , 2016 , 36 ( 5 ): 848 - 872 .

BEZZA F A , CHIRWA E M N . Pyrene biodegradation enhancement potential of lipopeptide biosurfactant produced by Paenibacillus dendritiformis CN5 strain [J ] . Journal of Hazardous Materials , 2017 , 321 : 218 - 227 .

BEZZA F A , NKHALAMBAYAUSI CHIRWA E M . Biosurfactant from Paenibacillus dendritiformis and its application in assisting polycyclic aromatic hydrocarbon (PAH) and motor oil sludge removal from contaminated soil and sand media [J ] . Process Safety and Environmental Protection , 2015 , 98 : 354 - 364 .

BEZZA F A , CHIRWA E M N . The role of lipopeptide biosurfactant on microbial remediation of aged polycyclic aromatic hydrocarbons (PAHs)-contaminated soil [J ] . Chemical Engineering Journal , 2017 , 309 : 563 - 576 .

BOCHYNEK M , LEWIŃSKA A , WITWICKI M , et al . Formation and structural features of micelles formed by surfactin homologues [J ] . Frontiers in Bioengineering and Biotechnology , 2023 , 11 : 1211319 .

LI J L , CHEN B H . Surfactant-mediated biodegradation of polycyclic aromatic hydrocarbons [J ] . Materials , 2009 , 2 ( 1 ): 76 - 94 .

PARUS A , CIESIELSKI T , WOŹNIAK-KARCZEWSKA M , et al . Basic principles for biosurfactant-assisted (bio)remediation of soils contaminated by heavy metals and petroleum hydrocarbons – a critical evaluation of the performance of rhamnolipids [J ] . Journal of Hazardous Materials , 2023 , 443 : 130171 .

DASGUPTA A , SAHA S , GANGULI P , et al . Characterization of pumilacidin, a lipopeptide biosurfactant produced from bacillus pumilus NITDID1 and its prospect in bioremediation of hazardous pollutants [J ] . Archives of Microbiology , 2023 , 205 ( 8 ): 274 .

SINGH A K , CAMEOTRA S S . Efficiency of lipopeptide biosurfactants in removal of petroleum hydrocarbons and heavy metals from contaminated soil [J ] . Environmental Science and Pollution Research , 2013 , 20 ( 10 ): 7367 - 7376 .

NARENKUMAR J , DAS B , ABILAJI S , et al . Biosurfactant-assisted bio-electrokinetic enhanced remediation of heavy metal-contaminated soil [J ] . Frontiers in Microbiology , 2024 , 15 .

SHANG W , ZHANG Y M , DING M Z , et al . Improved engineered fungal-bacterial commensal consortia simultaneously degrade multiantibiotics and biotransform food waste into lipopeptides [J ] . Journal of Environmental Management , 2024 , 371 : 123177 .

FENG Y , LIN D , YANG K , et al . A novel Bacillus cereus KB-2 strain for highly efficient bioregeneration of high-temperature biochar after sulfamethoxazole adsorption [J ] . Environmental Research , 2026 , 293 : 123694 .

RAJ A , KUMAR A , DAMES J F . Tapping the role of microbial biosurfactants in pesticide remediation: an eco-friendly approach for environmental sustainability [J ] . Frontiers in Microbiology , 2021 , 12 .

JAKINALA P , LINGAMPALLY N , KYAMA A , et al . Enhancement of atrazine biodegradation by marine isolate bacillus velezensis MHNK1 in presence of surfactin lipopeptide [J ] . Ecotoxicology and Environmental Safety , 2019 , 182 : 109372 .

SCHALCHLI H , LAMILLA C , RUBILAR O , et al . Production and characterization of a biosurfactant produced by Bacillus amyloliquefaciens C11 for enhancing the solubility of pesticides [J ] . Journal of Environmental Chemical Engineering , 2023 , 11 ( 6 ): 111572 .

SATAPUTE P , JOGAIAH S . A biogenic microbial biosurfactin that degrades difenoconazole fungicide with potential antimicrobial and oil displacement properties [J ] . Chemosphere , 2022 , 286 : 131694 .

ODUKKATHIL G , VASUDEVAN N . Biodegradation of endosulfan isomers and its metabolite endosulfate by two biosurfactant producing bacterial strains of bordetella petrii [J ] . Journal of Environmental Science and Health. Part . B, Pesticides, Food Contaminants, and Agricultural Wastes, 2015 , 50 ( 2 ): 81 - 89 .

AWASTHI N , KUMAR A , MAKKAR R , et al . Biodegradation of soil-applied endosulfan in the presence of a biosurfactant [J ] . Journal of Environmental Science and Health, Part B , 1999 , 34 ( 5 ): 793 - 803 .

TISO T , DEMLING P , KARMAINSKI T , et al . Foam control in biotechnological processes—challenges and opportunities [J ] . Discover Chemical Engineering , 2024 , 4 ( 1 ): 2 .

LEE B S , KIM E K . Lipopeptide production from Bacillus sp. GB16 using a novel oxygenation method [J ] . Enzyme and Microbial Technology , 2004 , 35 ( 6 ): 639 - 647 .

KHONDEE N , TATHONG S , PINYAKONG O , et al . Lipopeptide biosurfactant production by chitosan-immobilized Bacillus sp. GY19 and their recovery by foam fractionation [J ] . Biochemical Engineering Journal , 2015 , 93 : 47 - 54 .

VAN NIEKERK K , POTT R W M . The in situ production and separation of surfactin, iturin, and fengycin lipopeptides in an aqueous two-phase system [J ] . Journal of Surfactants and Detergents , 2025 , 28 ( 5 ): 1127 - 1136 .

GUDIÑA E J , TEIXEIRA J A . Bacillus licheniformis : the unexplored alternative for the anaerobic production of lipopeptide biosurfactants? [J ] . Biotechnology Advances , 2022 , 60 : 108013 .

BINIARZ P , HENKEL M , HAUSMANN R , et al . Development of a bioprocess for the production of cyclic lipopeptides pseudofactins with efficient purification from collected foam [J ] . Frontiers in Bioengineering and Biotechnology , 2020 , 8 : 565619 .

TREINEN C , CLAASSEN L , HOFFMANN M , et al . Evaluation of an external foam column for in situ product removal in aerated surfactin production processes [J ] . Frontiers in Bioengineering and Biotechnology , 2023 , 11 : 1264787 .

GEISSLER M , HERAVI K M , HENKEL M , et al . Lipopeptide biosurfactants from bacillus species [J ] . Biobased Surfactants (Second Edition) , 2019 : 205 - 240 .

TRAN K M , NONG N T , REN J , et al . Genetic "expiry-date" circuits control lifespan of synthetic scavenger bacteria for safe bioremediation [J ] . Nucleic Acids Research , 2025 , 53 ( 14 ): gkaf703 .

HAYASHI N , LAI Y , FUERTE-STONE J , et al . Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements [J ] . Nature Communications , 2024 , 15 ( 1 ): 2096 .

HARTIG A M , DAI W , ZHANG K , et al . Influence of environmental conditions on the escape rates of biocontained genetically engineered microbes [J ] . Environmental Science & Technology , 2024 , 58 ( 51 ): 22657 - 22667 .

SONG X , TIAN C , WANG P , et al . Thermal kill-switches based biocontainment for genetically engineered cyanobacteria [J ] . Chemical Engineering Journal , 2026 , 527 : 171691 .

LI S , ZUO X , CARPENTER M D , et al . Microbial bioelectronic sensors for environmental monitoring [J ] . Nature Reviews Bioengineering , 2025 , 3 ( 1 ): 31 - 49 .

LI Y , LUCCI T , VILLARRUEL DUJOVNE M , et al . A cell-free biosensor signal amplification circuit with polymerase strand recycling [J ] . Nature Chemical Biology , 2025 , 21 ( 6 ): 949 - 958 .

GALLAGHER R R , PATEL J R , INTERIANO A L , et al . Multilayered genetic safeguards limit growth of microorganisms to defined environments [J ] . Nucleic Acids Research , 2015 , 43 ( 3 ): 1945 - 1954 .

MANEIRA C , BECKER S , CHAMAS A , et al . A multilayered biocontainment system for laboratory and probiotic yeast [J ] . Metabolic Engineering , 2025 , 91 : 442 - 454 .

MA Y , MANNA A , MOON T S . Advances in engineering genetic circuits for microbial biocontainment [J ] . Current Opinion in Systems Biology , 2023 , 36 : 100483 .

HOFFMANN S A , DIGGANS J , DENSMORE D , et al . Safety by design: biosafety and biosecurity in the age of synthetic genomics [J ] . iScience , 2023 , 26 ( 3 ): 106165 .

MOON T S . Be a GEM: biocontained, environmentally applied, genetically engineered microbes [J ] . Advanced Drug Delivery Reviews , 2025 , 221 : 115578 .

SU Y , GAO L , LI C , et al . Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains [J ] . Microbial Cell Factories , 2024 , 23 ( 1 ): 94 .

MESSENGER S R , MCGUINNIETY E M R , STEVENSON L J , et al . Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides [J ] . Nature Chemical Biology , 2024 , 20 ( 2 ): 251 - 260 .

ZHANG Z , ZHOU Y , XIE S , et al . NRPStransformer, an accurate adenylation domain specificity prediction algorithm for genome mining of nonribosomal peptides [J ] . Journal of the American Chemical Society , 2025 , 147 ( 36 ): 32662 - 32670 .

LIU Y , XUE B , LIU H , et al . Rational construction of synthetic consortia: key considerations and model-based methods for guiding the development of a novel biosynthesis platform [J ] . Biotechnology Advances , 2024 , 72 : 108348 .

JANSSON J K , MCCLURE R , EGBERT R G . Soil microbiome engineering for sustainability in a changing environment [J ] . Nature Biotechnology , 2023 , 41 ( 12 ): 1716 - 1728 .

RUAN Z , CHEN K , CAO W , et al . Engineering natural microbiomes toward enhanced bioremediation by microbiome modeling [J ] . Nature Communications , 2024 , 15 ( 1 ): 4694 .

BAO T , QIAN Y , XIN Y , et al . Engineering microbial division of labor for plastic upcycling [J ] . Nature Communications , 2023 , 14 ( 1 ): 5712 .

VAN LENT P , SCHMITZ J , ABEEL T . Simulated design–build–test–learn cycles for consistent comparison of machine learning methods in metabolic engineering [J ] . ACS Synthetic Biology , 2023 , 12 ( 9 ): 2588 - 2599 .

RAI K , WANG Y , O'CONNELL R W , et al . Using machine learning to enhance and accelerate synthetic biology [J ] . Current Opinion in Biomedical Engineering , 2024 , 31 : 100553 .

RAPP J T , BREMER B J , ROMERO P A . Self-driving laboratories to autonomously navigate the protein fitness landscape [J ] . Nature Chemical Engineering , 2024 , 1 ( 1 ): 97 - 107 .

WACKETT L P , ROBINSON S L . A prescription for engineering PFAS biodegradation [J ] . Biochemical Journal , 2024 , 481 ( 23 ): 1757 - 1770 .

YU Y , XU F , ZHAO W , et al . Electron bifurcation and fluoride efflux systems implicated in defluorination of perfluorinated unsaturated carboxylic acids by acetobacterium spp [J ] . Science Advances , 2024 , 10 ( 29 ): eado2957 .

ZIMMERMANN W . Polyester-degrading enzymes in a circular economy of plastics [J ] . Nature Reviews Bioengineering , 2025 , 3 ( 8 ): 681 - 696 .

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State Key Laboratory of Microbial Metabolism， School of Life Sciences and Biotechnology， Shanghai Jiao Tong University

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State Key Laboratory of Microbial Metabolism， Shanghai Jiao Tong University

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