合成气发酵装备、工艺及商业化进展研究

白雪; 梁楠; 李欣启; 莫志朋; 佟淑环; 岳美琪; 贾晓静; 任康; 息晓杰; 晁伟

doi:10.12211/2096-8280.2025-001

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合成气发酵装备、工艺及商业化进展研究

特约评述 | 更新时间：2025-02-24

- 合成气发酵装备、工艺及商业化进展研究
- Research on the equipment, process, and commercialization progress of syngas fermentation
- 合成生物学 2025年页码：1-22
- 作者机构：
  
  1.北京首钢朗泽科技股份有限公司，北京 100043
  2.河北首朗新能源科技有限公司，河北唐山 063200
- 作者简介：
  
  [ "白雪（1989—），女，博士。研究方向为乙醇梭菌的遗传改造与代谢工程，并开发适用于乙醇梭菌筛选的高通量设备及方法，促进其工业化应用。E-mail：baixue@sgltne.com" ]
  [ "晁伟（1982—），男，博士，高级工程师。研究方向为工业尾气生物转化制乙醇、蛋白和产业化应用。E-mail：chaowei@sgltne.com" ]
- 基金信息：
  
  国家重点研发计划(2024YFA0918100)
- DOI：10.12211/2096-8280.2025-001
  中图分类号： Q815
- 收稿：2025-01-02，
  
  修回：2025-02-21，
  
  网络首发：2025-02-24，
- 稿件说明：
移动端阅览
白雪，梁楠，李欣启，莫志朋，佟淑环，岳美琪，贾晓静，任康，息晓杰，晁伟. 合成气发酵装备、工艺及商业化进展研究［J］. 合成生物学， 2025， 6. DOI： 10.12211/2096-8280.2025-001

BAI Xue， LIANG Nan， LI Xinqi， MO Zhipeng， TONG Shuhuan， YUE Meiqi， JIA Xiaojing， REN Kang， XI Xiaojie， CHAO Wei. Research on the equipment， process， and commercialization progress of syngas fermentation［J］. Synthetic Biology Journal， 2025， 6. DOI： 10.12211/2096-8280.2025-001
白雪，梁楠，李欣启，莫志朋，佟淑环，岳美琪，贾晓静，任康，息晓杰，晁伟. 合成气发酵装备、工艺及商业化进展研究［J］. 合成生物学， 2025， 6. DOI： 10.12211/2096-8280.2025-001 DOI：

BAI Xue， LIANG Nan， LI Xinqi， MO Zhipeng， TONG Shuhuan， YUE Meiqi， JIA Xiaojing， REN Kang， XI Xiaojie， CHAO Wei. Research on the equipment， process， and commercialization progress of syngas fermentation［J］. Synthetic Biology Journal， 2025， 6. DOI： 10.12211/2096-8280.2025-001 DOI：

摘要

在全球气候变暖日益加剧的背景下，探索并实施有效的碳减排策略，已成为应对这一全球性挑战的当务之急。合成气发酵技术作为一种减少温室气体排放、回收工业尾气并生产可再生燃料和化学品的绿色低碳技术，在全球气候缓解和循环经济转型中发挥着重要作用。工业菌种被认为是生物发酵的“芯片”，而在合成气发酵技术转化落地过程中，新装备、新工艺的开发同样重要。本文综述了在合成气发酵领域菌种端和工业应用端重要装备的研究进展，总结了包括原料气净化处理、气体发酵、产物分离提取等工艺在内的全流程合成气发酵集成技术的发展和面临的挑战，系统梳理了合成气发酵商业化项目的发展脉络，指出技术的工程转化与推广不仅要求技术上的革新突破，更需要前瞻的商业布局以及政策的支持，为合成气发酵技术的发展和商业化项目复制推广提供重要参考。

Abstract

In the context of the increasingly severe global climate warming

exploring and implementing effective carbon reduction strategies has become an urgent priority to address this global challenge. Syngas fermentation

as a green low-carbon technology that reduces greenhouse gas emissions

recycles industrial waste gas

and produces renewable fuels and chemicals

plays an important role in global climate mitigation and the transition to a circular economy. Industrial strains are considered the "chips" of fermentation

and in the process of transforming and implementing syngas fermentation technology

the development of new equipment and new processes is equally important. Firstly

this article reviews the research progress on important equipment in the fields of strain development and industrial application of syngas fermentation. It summarizes the latest advancements in high-throughput cultivation and screening of anaerobic microorganisms in syngas atmosphere. The application of this technology will accelerate the optimization and iteration of industrial strains for syngas fermentation

providing better-performing industrial strains for commercial application. Then

the review outlines the research progress of various types of reactors currently used for syngas fermentation

including stirred tank reactors

bubble column reactors

gas-lift reactors

trickle bed reactors

and hollow fiber membrane reactors

and discusses the potential and challenges of each type of reactor in industrial production. Among these reactors

the gas-lift reactor

due to its low energy consumption

simple structure

and good economic benefits

has been widely used in the commercial application of syngas fermentation. Secondly

the review summarizes the development and challenges faced by the integrated syngas fermentation technology

including raw gas purification

gas fermentation

and product separation and extraction processes. After an in-depth discussion of the development trajectory of commercialization projects for syngas fermentation

the review points out that the promotion of syngas fermentation not only require technological breakthroughs but also meticulous engineering management

forward-looking commercial planning

and strong policy support

all of which are core to advancing the technology from the laboratory to the market.

关键词

Keywords

references

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