合成生物学竞赛：驱动产学研融合的新引擎

晏雄鹰; 王依; 耿碧男; 何桥宁; 杨世辉

doi:10.12211/2096-8280.2025-080

您当前的位置：

首页 >

文章列表页 >

合成生物学竞赛：驱动产学研融合的新引擎

特约评述 | 更新时间：2026-01-15

- 合成生物学竞赛：驱动产学研融合的新引擎
- Synthetic biology competitions： a new engine driving the integration of education， research and development， and entrepreneurship
- 合成生物学 2025年6卷第6期页码：1277-1293
- 作者机构：
  
  湖北大学生命科学学院，湖北武汉 430062
- 作者简介：
  
  [ "晏雄鹰（1998—），男，博士后。研究方向为微生物代谢工程与合成生物学。 E-mail：xiongying.Yan@stu.hubu.edu.cn" ]
  [ "何桥宁（1990—），女，博士，教授，博士生导师。研究方向为合成生物学，代谢工程，合成生物制造。 E-mail：Qiaoninghe@hubu.edu.cn" ]
  [ "杨世辉（1971—），男，博士，教授，博士生导师，武汉睿嘉康生物科技有限公司创始人。研究方向为微生物代谢工程、合成生物学，生物能源与绿色生物制造等。 E-mail：Shihui.Yang@hubu.edu.cn" ]
- 基金信息：
  
  国家重点研发计划“合成生物学”重点专项(2022YFA0911800);武汉市科技创新局成果转化项目(2024030803010187);湖北省技术创新计划(2024BCB025);武汉市自然科学基金特区计划(2024040701010048);湖北省国际科技合作基地项目(SH2318)
- DOI：10.12211/2096-8280.2025-080
  中图分类号： Q816
- 收稿：2025-08-01，
  
  修回：2025-11-05，
  
  纸质出版：2025-12-31
- 稿件说明：
移动端阅览
晏雄鹰，王依，耿碧男，何桥宁，杨世辉. 合成生物学竞赛：驱动产学研融合的新引擎［J］. 合成生物学， 2025， 6（6）： 1277-1293

YAN Xiongying， WANG Yi， GENG Bi′nan， HE Qiaoning， YANG Shihui. Synthetic biology competitions： a new engine driving the integration of education， research and development， and entrepreneurship［J］. Synthetic Biology Journal， 2025， 6（6）： 1277-1293
晏雄鹰，王依，耿碧男，何桥宁，杨世辉. 合成生物学竞赛：驱动产学研融合的新引擎［J］. 合成生物学， 2025， 6（6）： 1277-1293 DOI： 10.12211/2096-8280.2025-080.

YAN Xiongying， WANG Yi， GENG Bi′nan， HE Qiaoning， YANG Shihui. Synthetic biology competitions： a new engine driving the integration of education， research and development， and entrepreneurship［J］. Synthetic Biology Journal， 2025， 6（6）： 1277-1293 DOI： 10.12211/2096-8280.2025-080.

摘要

生命科学与信息技术的迅猛发展，不仅推动合成生物学发展成为一门新兴交叉学科，也加速了合成生物技术及生物制造产业的崛起，使之成为推动产业升级与生物经济增长的核心引擎。在这一背景下，合成生物学竞赛作为连接教育、科研与产业转化的关键枢纽，通过融合学科教育、创新创业实践以及初创企业孵化，有效促进了产学研深度融合。本文系统梳理了合成生物学及其竞赛体系的发展脉络，重点探讨了竞赛在人才培养、学科建设、技术创新与产业落地等方面的协同作用；同时，以湖北大学参赛实践作为案例，具体阐释了合成生物学竞赛对产学研融合的推动作用。针对当前面临的成果转化瓶颈、跨学科协作壁垒、合成生物学竞赛赛事优化等挑战，本文进一步从资源整合、评分机制、赛道发展、生物安全教育与伦理以及竞赛同质化这几大方面提出了可持续发展的优化路径，旨在为合成生物学领域的产教融合提供理论参考与实践策略。

Abstract

The rapid advancement of life sciences and information technology has not only propelled synthetic biology into a prominent interdisciplinary frontier but has also spurred the vigorous development of the synthetic biotechnology and biomanufacturing industry

making it a key engine driving the new wave of scientific and technological revolution and industrial transformation. In this context

synthetic biology competitions

serving as a critical nexus connecting education

research

and industrial translation

are increasingly playing a bridging and catalytic role. By integrating disciplinary education

innovative practice

and startup incubation

these competitions effectively promote deep integration and collaborative development among multiple stakeholders in academia

research

and industry. This review systematically reviews the evolution and current state of synthetic biology and its competition systems

with a focus on analyzing the synergistic mechanisms of competitions in talent cultivation

disciplinary development

technological innovation

and industrial application. Synthetic biology competitions not only provide a platform for interdisciplinary learning and practice for students but also facilitate the alignment of university research resources with industrial application needs

thereby promoting the translation of basic research into industrial applications. Using the participation practice of Hubei University as a case study

this paper further elucidates the specific effects of competitions in stimulating students’ innovative potential

promoting the restructuring of curriculum systems

and advancing the practical application of research outcomes

demonstrating their exemplary value in constructing regional innovation ecosystems. However

the development of synthetic biology competitions currently faces several challenges. On one hand

the pathway for translating scientific research achievements into industrialization remains obstructed

with issues such as insufficient technological maturity and gaps in funding support. On the other hand

interdisciplinary collaboration still encounters institutional barriers

and deeper integration among fields such as life sciences

engineering

and computer science needs to be strengthened. Additionally

the competition systems themselves face issues including imperfect evaluation mechanisms

homogenization in track design

and a lack of biosafety and ethics education

which hinder their sustainable development. In response to the aforementioned challenges

this review proposes a series of actionable optimization strategies from five aspects: resource integration

optimization of evaluation mechanisms

diversified development of competition tracks

enhancement of biosafety education and ethical norms

and avoidance of competition homogenization. Specific measures include establishing an integrated resource platform for industry-university-research

improving an evaluation system oriented towards innovation and application potential

expanding differentiated tracks catering to various stages and needs; strengthening the integration of biosafety and ethics education

and promoting the alignment of competitions with regional industrial characteristics. In summary

as an important vehicle for promoting the integration of industry and education

the healthy development of synthetic biology competitions is of great significance for advancing technological innovation and industrial upgrading in the field of synthetic biology.Through systematic analysis and case discussions

this review undertakes to furnish valuable theoretical references and practical strategies for educational practices and policy formulation in related fields

thereby fostering the construction and refinement of synthetic biology innovation ecosystem.

关键词

Keywords

references

YANG X H , JIANG Z H , YANG S H , et al . A framework for challenges and solutions in biodesign research [J ] . BioDesign Research , 2025 , 7 ( 3 ): 100029 .

ZHANG X N , LIU C L , DAI J B , et al . Enabling technology and core theory of synthetic biology [J ] . Science China Life Sciences , 2023 , 66 ( 8 ): 1742 - 1785 .

VENKATA MOHAN S , MODESTRA J A , AMULYA K , et al . A circular bioeconomy with biobased products from CO 2 sequestration [J ] . Trends in Biotechnology , 2016 , 34 ( 6 ): 506 - 519 .

CAMERON D E , BASHOR C J , COLLINS J J . A brief history of synthetic biology [J ] . Nature Reviews Microbiology , 2014 , 12 ( 5 ): 381 - 390 .

NIELSEN J , KEASLING J D . Synergies between synthetic biology and metabolic engineering [J ] . Nature Biotechnology , 2011 , 29 ( 8 ): 693 - 695 .

VAN DEN BERGHE L , MASSCHELEIN J , PINHEIRO V B . From competition to cure: the development of live biotherapeutic products for anticancer therapy in the iGEM competition [J ] . Frontiers in Bioengineering and Biotechnology , 2024 , 12 : 1447176 .

GIBSON D G , YOUNG L , CHUANG R Y , et al . Enzymatic assembly of DNA molecules up to several hundred kilobases [J ] . Nature Methods , 2009 , 6 ( 5 ): 343 - 345 .

GIBSON D G , GLASS J I , LARTIGUE C , et al . Creation of a bacterial cell controlled by a chemically synthesized genome [J ] . Science , 2010 , 329 ( 5987 ): 52 - 56 .

HUTCHISON C A , CHUANG R Y , NOSKOV V N , et al . Design and synthesis of a minimal bacterial genome [J ] . Science , 2016 , 351 ( 6280 ): aad6253 .

RO D K , PARADISE E M , OUELLET M , et al . Production of the antimalarial drug precursor artemisinic acid in engineered yeast [J ] . Nature , 2006 , 440 ( 7086 ): 940 - 943 .

JUMPER J , EVANS R , PRITZEL A , et al . Highly accurate protein structure prediction with AlphaFold [J ] . Nature , 2021 , 596 ( 7873 ): 583 - 589 .

中国科学院分子植物科学卓越创新中心/植物生理生态研究所 . 中国科学院合成生物学重点实验室 [J ] . 中国科学院院刊 , 2018 , 33 ( 11 ): 1258 - 1259 .

CAS Center for Excellence in Molecular Plant Science, Shanghai Institute of Plant Physiology and Ecology, CAS . Key laboratory of Synthetic Biology, CAS [J ] . Bulletin of Chinese Academy of Sciences , 2018 , 33 ( 11 ): 1258 - 1259 .

简甜甜 , 李遂焰 , 廖海 , 等 . 合成生物学与国际遗传工程机器大赛对培养大学生双创思维与能力的影响 [J ] . 生物工程学报 , 2022 , 38 ( 4 ): 1619 - 1630 .

JIAN T T , LI S Y , LIAO H , et al . Cultivation of college students’innovative and entrepreneurial thinking and ability based on Synthetic Biology and iGEM [J ] . Chinese Journal of Biotechnology , 2022 , 38 ( 4 ): 1619 - 1630 .

赵霞 , 卢曙光 , 王竞 , 等 . 国际基因工程机器大赛在中国 [J ] . 生物工程学报 , 2018 , 34 ( 12 ): 1915 - 1922 .

ZHAO X , LU S G , WANG J , et al . Development of international genetically engineered machine competition in China [J ] . Chinese Journal of Biotechnology , 2018 , 34 ( 12 ): 1915 - 1922 .

DIEP P , BOUCINHA A , KELL B , et al . Advancing undergraduate synthetic biology education: insights from a Canadian iGEM student perspective [J ] . Canadian Journal of Microbiology , 2021 , 67 ( 10 ): 749 - 770 .

BIGGS J B . Teaching for quality learning at university [M ] . 2nd edition . Buckingham : The Society for research into Higher Education and Open University Press , 2003 .

吕原野 , 张益豪 , 王博祥 , 等 . 国际基因工程机器大赛对本科生科研教育的启示 [J ] . 生物工程学报 , 2018 , 34 ( 12 ): 1923 - 1930 .

LÜ Y Y , ZHANG Y H , WANG B X , et al . Bringing scientific research education closer to undergraduates through International Genetically Engineered Machine competition [J ] . Chinese Journal of Biotechnology , 2018 , 34 ( 12 ): 1923 - 1930 .

XIE X M , YANG K X , LU Y P , et al . Broad-spectrum and effective rare earth enriching via Lanmodulin-displayed Yarrowia lipolytica [J ] . Journal of Hazardous Materials , 2022 , 438 : 129561 .

SUN Y Y , YAN L , SUN J J , et al . Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8 + T cell detection [J ] . Nature Communications , 2022 , 13 : 3916 .

WU Y , LI B Z , ZHAO M , et al . Bug mapping and fitness testing of chemically synthesized chromosome X [J ] . Science , 2017 , 355 ( 6329 ): eaaf4706 .

XIE Z X , LI B Z , MITCHELL L A , et al . “Perfect” designer chromosome Ⅴ and behavior of a ring derivative [J ] . Science , 2017 , 355 ( 6329 ): eaaf4704 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

合成生物制造进展

合成生物学赋能细胞膜纳米颗粒的精准诊疗

合成生物学策略下的人工血液研究进展