黄酮类化合物生物合成及其在化妆品中应用的研究

韦灵珍; 王佳; 孙新晓; 袁其朋; 申晓林

doi:10.12211/2096-8280.2024-058

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黄酮类化合物生物合成及其在化妆品中应用的研究

特约评述 | 更新时间：2025-05-20

- 黄酮类化合物生物合成及其在化妆品中应用的研究
- Biosynthesis of flavonoids and their applications in cosmetics
- 合成生物学 2025年6卷第2期页码：373-390
- 作者机构：
  
  北京化工大学化工资源有效利用全国重点实验室，北京 100029
- 作者简介：
  
  [ "韦灵珍（2001—），女，硕士研究生。研究方向为代谢工程及合成生物学。E-mail：2024201324@mail.buct.edu.cn" ]
  [ "申晓林（1984—），女，博士，教授。研究方向为代谢工程及合成生物学。E-mail：shenxl@mail.buct.edu.cn" ]
- 基金信息：
  
  国家自然科学基金(22078011)
- DOI：10.12211/2096-8280.2024-058
  中图分类号： Q812
- 收稿：2024-07-31，
  
  修回：2024-10-26，
  
  纸质出版：2025-04-30
- 稿件说明：
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韦灵珍，王佳，孙新晓，袁其朋，申晓林. 黄酮类化合物生物合成及其在化妆品中应用的研究［J］. 合成生物学， 2025， 6（2）： 373-390

WEI Lingzhen， WANG Jia， SUN Xinxiao， YUAN Qipeng， SHEN Xiaolin. Biosynthesis of flavonoids and their applications in cosmetics［J］. Synthetic Biology Journal， 2025， 6（2）： 373-390
韦灵珍，王佳，孙新晓，袁其朋，申晓林. 黄酮类化合物生物合成及其在化妆品中应用的研究［J］. 合成生物学， 2025， 6（2）： 373-390 DOI： 10.12211/2096-8280.2024-058.

WEI Lingzhen， WANG Jia， SUN Xinxiao， YUAN Qipeng， SHEN Xiaolin. Biosynthesis of flavonoids and their applications in cosmetics［J］. Synthetic Biology Journal， 2025， 6（2）： 373-390 DOI： 10.12211/2096-8280.2024-058.

摘要

黄酮类化合物是一类广泛存在于自然界中的多酚类化合物，因其显著的抗氧化、抗炎、抗菌等生物活性在化妆品中广泛应用。然而，传统植物提取方法的局限性促使研究人员转向合成生物学以寻求更高效的生产途径。本文根据美白抗氧化、抗菌消炎、防晒抗衰老和增色增彩四个功能分类分别列举了几种常见黄酮类化合物在化妆品中的应用；介绍了黄酮类化合物的现有生物合成途径并总结了典型黄酮类化合物的最新研究进展；详细讨论了合成生物学及代谢工程策略。接着，针对黄酮类化合物在化妆品应用中的水溶性差和稳定性低的问题，总结了相应解决方案的研究进程。最后，总结并展望了人工智能辅助合成生物学的策略以应对黄酮类化合物合成过程中的挑战。同时，本文强调了黄酮类化合物的安全性和有效性评估的重要性，以推动其在化妆品行业的应用。

Abstract

Flavonoids are natural ingredients commonly used in cosmetics

mainly for their antioxidant and anti-inflammatory effects

but they also present a variety of other biological activities such as antimicrobial

whitening

and anti-ultraviolet. Therefore

flavonoids have a huge application potential waiting to be explored. In this review

firstly

the numerous biological properties of flavonoids used in cosmetics

as well as examples of their applications in cosmetics are presented

with their biosynthetic pathways addressed. Then

recent advances in biosynthesis of typical flavonoids (

e.g

phloretin

naringenin

apigenin

luteolin

chrysin

rutin

and anthocyanins) are reviewed and discussed

with a focus on the novel synthetic biology and metabolic engineering strategies to improve the productivity and yield of biosynthesized flavonoids

including the enhancement of precursor supply

characterization and modification of key enzymes

regulation of gene expression

and optimization of fermentation processes. With the continuous innovation of synthetic biology technology

there has been an increase in the efficiency of flavonoid biosynthesis and a significant reduction in production cost

which contributes substantially to the widespread use of flavonoids in cosmetics. However

the prevalence of poor solubility and low stability of flavonoids

limits their applications in cosmetics. To address this issue

we outline the research process of two main strategies: nanocarrier technology and moiety modification. The application of these research results opens up new possibilities for the use of flavonoids in cosmetics. At the end

we discuss two major challenges in high-yield synthesis of complex flavonoids: the difficulty of key enzyme modification and the imbalance of metabolic flux. We also look forward to AI-assisted synthetic biology to address these challenges and drive the yield improvement and industrialization of flavonoid biosynthesis

providing biotechnological power for the development and innovation of the cosmetics industry.

关键词

Keywords

references

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