KNÖFLER M , HAIDER S , SALEH L , et al . Human placenta and trophoblast development: key molecular mechanisms and model systems [J ] . Cellular and Molecular Life Sciences , 2019 , 76 ( 18 ): 3479 - 3496 .

ROSENFELD C S . Transcriptomics and other omics approaches to investigate effects of xenobiotics on the placenta [J ] . Frontiers in Cell and Developmental Biology , 2021 , 9 : 723656 .

ANDER S E , DIAMOND M S , COYNE C B . Immune responses at the maternal-fetal interface [J ] . Science Immunology , 2019 , 4 ( 31 ): eaat6114 .

BROSENS I , PIJNENBORG R , VERCRUYSSE L , et al . The “Great Obstetrical Syndromes” are associated with disorders of deep placentation [J ] . American Journal of Obstetrics and Gynecology , 2011 , 204 ( 3 ): 193 - 201 .

KRISHNA U , BHALERAO S . Placental insufficiency and fetal growth restriction [J ] . Journal of Obstetrics and Gynaecology of India , 2011 , 61 ( 5 ): 505 - 511 .

SMITH G C S . First-trimester determination of complications of late pregnancy [J ] . The Journal of the American Medical Association , 2010 , 303 ( 6 ): 561 - 562 .

SCHMIDT A , MORALES-PRIETO D M , PASTUSCHEK J , et al . Only humans have human placentas: molecular differences between mice and humans [J ] . Journal of Reproductive Immunology , 2015 , 108 : 65 - 71 .

CHAOUAT G , CLARK D A . Are animal models useful or confusing in understanding the human feto-maternal relationship? A debate [J ] . Journal of Reproductive Immunology , 2015 , 108 : 56 - 64 .

AUBUCHON M , SCHULZ L C , SCHUST D J . Preeclampsia: animal models for a human cure [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2011 , 108 ( 4 ): 1197 - 1198 .

MCCARTHY F P , KINGDOM J C , KENNY L C , et al . Animal models of preeclampsia; uses and limitations [J ] . Placenta , 2011 , 32 ( 6 ): 413 - 419 .

ROTHBAUER M , PATEL N , GONDOLA H , et al . A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines [J ] . Scientific Reports , 2017 , 7 ( 1 ): 5892 .

ABBAS Y , TURCO M Y , BURTON G J , et al . Investigation of human trophoblast invasion in vitro [J ] . Human Reproduction Update , 2020 , 26 ( 4 ): 501 - 513 .

CONINGS S , AMANT F , ANNAERT P , et al . Integration and validation of the ex vivo human placenta perfusion model [J ] . Journal of Pharmacological and Toxicological Methods , 2017 , 88 ( Pt 1 ): 25 - 31 .

MYLLYNEN P , MATHIESEN L , WEIMER M , et al . Preliminary interlaboratory comparison of the ex vivo dual human placental perfusion system [J ] . Reproductive Toxicology , 2010 , 30 ( 1 ): 94 - 102 .

ORENDI K , KIVITY V , SAMMAR M , et al . Placental and trophoblastic in vitro models to study preventive and therapeutic agents for preeclampsia [J ] . Placenta , 2011 , 32 ( Suppl ): S49 - S54 .

XIAO Z Y , YAN L , LIANG X Y , et al . Progress in deciphering trophoblast cell differentiation during human placentation [J ] . Current Opinion in Cell Biology , 2020 , 67 : 86 - 91 .

WONG F , COX B J . Cellular analysis of trophoblast and placenta [J ] . Placenta , 2017 , 59 : S2 - S7 .

LI L P , SCHUST D J . Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta [J ] . Reproductive Biology and Endocrinology , 2015 , 13 : 71 .

VARDHANA P A , ILLSLEY N P . Transepithelial glucose transport and metabolism in BeWo choriocarcinoma cells [J ] . Placenta , 2002 , 23 ( 8-9 ): 653 - 660 .

FUCHS R , ELLINGER I . Endocytic and transcytotic processes in villous syncytiotrophoblast: role in nutrient transport to the human fetus [J ] . Traffic , 2004 , 5 ( 10 ): 725 - 738 .

MARTINEZ F , OLVERA-SANCHEZ S , ESPARZA-PERUSQUIA M , et al . Multiple functions of syncytiotrophoblast mitochondria [J ] . Steroids , 2015 , 103 : 11 - 22 .

COSTA M A . The endocrine function of human placenta: an overview [J ] . Reproductive BioMedicine Online , 2016 , 32 ( 1 ): 14 - 43 .

PIJNENBORG R , DIXON G , ROBERTSON W B , et al . Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy [J ] . Placenta , 1980 , 1 ( 1 ): 3 - 19 .

HE N N , VAN IPEREN L , JONG D D , et al . Human extravillous trophoblasts penetrate decidual veins and lymphatics before remodeling spiral arteries during early pregnancy [J ] . PLoS One , 2017 , 12 ( 1 ): e0169849 .

MORLEY L C , BEECH D J , WALKER J J , et al . Emerging concepts of shear stress in placental development and function [J ] . Molecular Human Reproduction , 2019 , 25 ( 6 ): 329 - 339 .

CHANG C W , WAKELAND A K , PARAST M M . Trophoblast lineage specification, differentiation and their regulation by oxygen tension [J ] . The Journal of Endocrinology , 2018 , 236 ( 1 ): R43 - R56 .

ROBERTS V H J , MORGAN T K , BEDNAREK P , et al . Early first trimester uteroplacental flow and the progressive disintegration of spiral artery plugs: new insights from contrast-enhanced ultrasound and tissue histopathology [J ] . Human Reproduction , 2017 , 32 ( 12 ): 2382 - 2393 .

WEISS G , SUNDL M , GLASNER A , et al . The trophoblast plug during early pregnancy: a deeper insight [J ] . Histochemistry and Cell Biology , 2016 , 146 ( 6 ): 749 - 756 .

JAMES J L , WHITLEY G S , CARTWRIGHT J E . Shear stress and spiral artery remodelling: the effects of low shear stress on trophoblast-induced endothelial cell apoptosis [J ] . Cardiovascular Research , 2011 , 90 ( 1 ): 130 - 139 .

BURTON G J , CINDROVA-DAVIES T , YUNG H W , et al . Hypoxia and reproductive health: oxygen and development of the human placenta [J ] . Reproduction , 2021 , 161 ( 1 ): F53 - F65 .

JAMES J L , SAGHIAN R , PERWICK R , et al . Trophoblast plugs: impact on utero-placental haemodynamics and spiral artery remodelling [J ] . Human Reproduction , 2018 , 33 ( 8 ): 1430 - 1441 .

JAUNIAUX E , WATSON A L , HEMPSTOCK J , et al . Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure [J ] . The American Journal of Pathology , 2000 , 157 ( 6 ): 2111 - 2122 .

BURTON G J , WOODS A W , JAUNIAUX E , et al . Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy [J ] . Placenta , 2009 , 30 ( 6 ): 473 - 482 .

BURTON G J , REDMAN C W , ROBERTS J M , et al . Pre-eclampsia: pathophysiology and clinical implications [J ] . British Medical Journal , 2019 , 366 : l2381 .

ROTH C J , HAEUSSNER E , RUEBELMANN T , et al . Dynamic modeling of uteroplacental blood flow in IUGR indicates vortices and elevated pressure in the intervillous space - a pilot study [J ] . Scientific Reports , 2017 , 7 : 40771 .

AL-NASIRY S , SPITZ B , HANSSENS M , et al . Differential effects of inducers of syncytialization and apoptosis on BeWo and JEG-3 choriocarcinoma cells [J ] . Human Reproduction , 2006 , 21 ( 1 ): 193 - 201 .

KNYAZEV E N , NIKULIN S V , KHRISTICHENKO A Y , et al . Transport and toxicity of 5-fluorouracil, doxorubicin, and cyclophosphamide in in vitro placental barrier model based on BeWo b30 cells [J ] . Russian Chemical Bulletin , 2019 , 68 ( 12 ): 2344 - 2349 .

KLOET S K , WALCZAK A P , LOUISSE J , et al . Translocation of positively and negatively charged polystyrene nanoparticles in an in vitro placental model [J ] . Toxicology in Vitro , 2015 , 29 ( 7 ): 1701 - 1710 .

KAWAMURA E , HAMILTON G B , MISKIEWICZ E I , et al . Examination of FERMT1 expression in placental chorionic villi and its role in HTR8-SVneo cell invasion [J ] . Histochemistry and Cell Biology , 2021 , 155 ( 6 ): 669 - 681 .

NONG Y Q , LI S F , LIU W J , et al . Aquaporin 3 promotes human extravillous trophoblast migration and invasion [J ] . Reproductive Biology and Endocrinology , 2021 , 19 ( 1 ): 49 .

NURSALIM Y N S , GROOM K M , BLENKIRON C , et al . A simple method to isolate term trophoblasts and maintain them in extended culture [J ] . Placenta , 2021 , 108 : 1 - 10 .

CASTEL G , MEISTERMANN D , BRETIN B , et al . Induction of human trophoblast stem cells from somatic cells and pluripotent stem cells [J ] . Cell Reports , 2020 , 33 ( 8 ): 108419 .

LIU X D , OUYANG J F , ROSSELLO F J , et al . Reprogramming roadmap reveals route to human induced trophoblast stem cells [J ] . Nature , 2020 , 586 ( 7827 ): 101 - 107 .

WEI Y X , WANG T Y , MA L S , et al . Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells [J ] . Science Advances , 2021 , 7 ( 33 ): eabf4416 .

NAAMA M , RAHAMIM M , ZAYAT V , et al . Pluripotency-independent induction of human trophoblast stem cells from fibroblasts [J ] . Nature Communications , 2023 , 14 ( 1 ): 3359 .

OKAE H , TOH H , SATO T , et al . Derivation of human trophoblast stem cells [J ] . Cell Stem Cell , 2018 , 22 ( 1 ): 50 - 63.e6 .

LEE J S , ROMERO R , HAN Y M , et al . Placenta-on-a-chip: a novel platform to study the biology of the human placenta [J ] . The Journal of Maternal-Fetal & Neonatal Medicine , 2016 , 29 ( 7 ): 1046 - 1054 .

CAO R K , WANG Y Q , LIU J Y , et al . Self-assembled human placental model from trophoblast stem cells in a dynamic organ-on-a-chip system [J ] . Cell Proliferation , 2023 , 56 ( 5 ): e13469 .

BLUNDELL C , YI Y S , MA L , et al . Placental drug transport-on-a-chip: a microengineered in vitro model of transporter-mediated drug efflux in the human placental barrier [J ] . Advanced Healthcare Materials , 2018 , 7 ( 2 ): 1700786 .

BLUNDELL C , TESS E R , SCHANZER A S , et al . A microphysiological model of the human placental barrier [J ] . Lab on a Chip , 2016 , 16 ( 16 ): 3065 - 3073 .

YIN F C , ZHU Y J , ZHANG M , et al . A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier [J ] . Toxicology in Vitro , 2019 , 54 : 105 - 113 .

ZHU Y J , YIN F C , WANG H , et al . Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection [J ] . ACS Biomaterials Science & Engineering , 2018 , 4 ( 9 ): 3356 - 3363 .

LI Q , SHARKEY A , SHERIDAN M , et al . Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy [J ] . Cell Stem Cell , 2024 , 31 ( 2 ): 181 - 195.e9 .

PARK J Y , MANI S , CLAIR G , et al . A microphysiological model of human trophoblast invasion during implantation [J ] . Nature Communications , 2022 , 13 ( 1 ): 1252 .

HIGHET A R , KHODA S M , BUCKBERRY S , et al . Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion [J ] . European Journal of Cell Biology , 2015 , 94 ( 12 ): 589 - 602 .

WONG M K , LI E W , ADAM M , et al . Establishment of an in vitro placental barrier model cultured under physiologically relevant oxygen levels [J ] . Molecular Human Reproduction , 2020 , 26 ( 5 ): 353 - 365 .

HU X Q , ZHANG L B . Hypoxia and mitochondrial dysfunction in pregnancy complications [J ] . Antioxidants , 2021 , 10 ( 3 ): 405 .

WOO J H , LEE I , KIM S M , et al . Recapitulation of trophoblast invasion during pregnancy in a physiological hypoxia induced microfluidic device [C/OL ] // ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference , July 28–August 1 , 2019 , San Francisco, California, USA . (2019-11-20)[2024-03-01] . https://doi.org/10.1115/AJKFluids2019-5002 https://doi.org/10.1115/AJKFluids2019-5002 .

LECARPENTIER E , BHATT M , BERTIN G I , et al . Computational fluid dynamic simulations of maternal circulation: wall shear stress in the human placenta and its biological implications [J ] . PLoS One , 2016 , 11 ( 1 ): e0147262 .

BRUGGER B A , GUETTLER J , GAUSTER M . Go with the flow-trophoblasts in flow culture [J ] . International Journal of Molecular Sciences , 2020 , 21 ( 13 ): 4666 .

MIURA S , SATO K , KATO-NEGISHI M , et al . Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6 [J ] . Nature Communications , 2015 , 6 : 8871 .

SANZ G , DANIEL N , AUBRIÈRE M C , et al . Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier [J ] . Biochimica et Biophysica Acta General Subjects , 2019 , 1863 ( 10 ): 1608 - 1618 .

HOLDER B S , TOWER C L , JONES C J , et al . Heightened pro-inflammatory effect of preeclamptic placental microvesicles on peripheral blood immune cells in humans [J ] . Biology of Reproduction , 2012 , 86 ( 4 ): 103 .

JONES C J P , FOX H . An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia [J ] . Placenta , 1980 , 1 ( 1 ): 61 - 76 .

RIQUELME G , VALLEJOS C , GREGORIO N D , et al . Lipid rafts and cytoskeletal proteins in placental microvilli membranes from preeclamptic and IUGR pregnancies [J ] . The Journal of Membrane Biology , 2011 , 241 ( 3 ): 127 - 140 .

ARISHE O O , EBEIGBE A B , WEBB R C . Mechanotransduction and uterine blood flow in preeclampsia: the role of mechanosensing Piezo 1 ion channels [J ] . American Journal of Hypertension , 2020 , 33 ( 1 ): 1 - 9 .

MA Z W , SAGRILLO-FAGUNDES L , MOK S , et al . Mechanobiological regulation of placental trophoblast fusion and function through extracellular matrix rigidity [J ] . Scientific Reports , 2020 , 10 ( 1 ): 5837 .

NABA A . TenYears of extracellular matrix proteomics: accomplishments, challenges, and future perspectives [J ] . Molecular & Cellular Proteomics , 2023 , 22 ( 4 ): 100528 .

NISHIGUCHI A , GILMORE C , SOOD A , et al . In vitro placent a barrier model using primary human trophoblasts, underlying connective tissue and vascular endothelium [J ] . Biomaterials , 2019 , 192 : 140 - 148 .

ZAMBUTO S G , RATTILA S , DVEKSLER G , et al . Effects of pregnancy-specific glycoproteins on trophoblast motility in three-dimensional gelatin hydrogels [J ] . Cellular and Molecular Bioengineering , 2022 , 15 ( 2 ): 175 - 191 .

MANDT D , GRUBER P , MARKOVIC M , et al . Fabrication of biomimetic placental barrier structures within a microfluidic device utilizing two-photon polymerization [J ] . International Journal of Bioprinting , 2018 , 4 ( 2 ): 144 .

WONG M K , SHAWKY S A , ARYASOMAYAJULA A , et al . Extracellular matrix surface regulates self-assembly of three-dimensional placental trophoblast spheroids [J ] . PLoS One , 2018 , 13 ( 6 ): e0199632 .

ABBAS Y , CARNICER-LOMBARTE A , GARDNER L , et al . Tissue stiffness at the human maternal-fetal interface [J ] . Human Reproduction , 2019 , 34 ( 10 ): 1999 - 2008 .

SHOJAEI S , ALI M S , SURESH M , et al . Dynamic placenta-on-a-chip model for fetal risk assessment of nanoparticles intended to treat pregnancy-associated diseases [J ] . Biochimica et Biophysica Acta Molecular Basis of Disease , 2021 , 1867 ( 7 ): 166131 .

ARUMUGASAAMY N , ROCK K D , KUO C Y , et al . Microphysiological systems of the placental barrier [J ] . Advanced Drug Delivery Reviews , 2020 , 161-162 : 161 - 175 .

KAZEMIAN A , HOOSHMANDABBASI R , SCHRANER E M , et al . Evolutionary implications of fetal and maternal microvillous surfaces in epitheliochorial placentae [J ] . Journal of Morphology , 2019 , 280 ( 4 ): 615 - 622 .

TUTAR R , ÇELEBI-SALTIK B . Modeling of artificial 3D human placenta [J ] . Cells , Tissues, Organs, 2022 , 211 ( 4 ): 527 - 536 .

LEACH L . The phenotype of the human materno-fetal endothelial barrier: molecular occupancy of paracellular junctions dictate permeability and angiogenic plasticity [J ] . Journal of Anatomy , 2002 , 200 ( 6 ): 599 - 606 .

MOORE K H , MURPHY H A , CHAPMAN H , et al . Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts [J ] . American Journal of Physiology Cell Physiology , 2021 , 321 ( 4 ): C694 - C703 .

WALKER N , FILIS P , SOFFIENTINI U , et al . Placental transporter localization and expression in the Human: the importance of species, sex, and gestational age differences [J ] . Biology of Reproduction , 2017 , 96 ( 4 ): 733 - 742 .

EVAIN-BRION D , MALASSINE A . Human placenta as an endocrine organ [J ] . Growth Hormone & IGF Research , 2003 , 13 : S34 - S37 .

D’HAUTERIVE S P , CLOSE R , GRIDELET V , et al . Human chorionic gonadotropin and early embryogenesis: review [J ] . International Journal of Molecular Sciences , 2022 , 23 ( 3 ): 1380 .

ZHANG N , WANG W S , LI W J , et al . Reduction of progesterone, estradiol and hCG secretion by perfluorooctane sulfonate via induction of apoptosis in human placental syncytiotrophoblasts [J ] . Placenta , 2015 , 36 ( 5 ): 575 - 580 .

ROGERS L M , HUGGINS M , DOSTER R S , et al . Impact of metabolic stress on BeWo syncytiotrophoblast function [J ] . ChemBioChem , 2023 , 24 ( 24 ): e202300410 .

BHATIA S N , INGBER D E . Microfluidic organs-on-chips [J ] . Nature Biotechnology , 2014 , 32 : 760 - 772 .

RENNERT K , STEINBORN S , GRÖGER M , et al . A microfluidically perfused three dimensional human liver model [J ] . Biomaterials , 2015 , 71 : 119 - 131 .

KIM H J , LI H , COLLINS J J , et al . Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2016 , 113 ( 1 ): E7 - E15 .

MAOZ B M , HERLAND A , FITZGERALD E A , et al . A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells [J ] . Nature Biotechnology , 2018 , 36 ( 9 ): 865 - 874 .

HUH D , MATTHEWS B D , MAMMOTO A , et al . Reconstituting organ-level lung functions on a chip [J ] . Science , 2010 , 328 ( 5986 ): 1662 - 1668 .

PU Y , GINGRICH J , VEIGA-LOPEZ A . A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening [J ] . Lab on a Chip , 2021 , 21 ( 3 ): 546 - 557 .

ABBAS Y , OEFNER C M , POLACHECK W J , et al . A microfluidics assay to study invasion of human placental trophoblast cells [J ] . Journal of the Royal Society , Interface, 2017 , 14 ( 130 ): 20170131 .

ZHANG W J , LI J W , ZHOU J Q , et al . Translational organoid technology - the convergence of chemical, mechanical, and computational biology [J ] . Trends in Biotechnology , 2022 , 40 ( 9 ): 1121 - 1135 .

TURCO M Y , GARDNER L , KAY R G , et al . Trophoblast organoids as a model for maternal-fetal interactions during human placentation [J ] . Nature , 2018 , 564 ( 7735 ): 263 - 267 .

HAIDER S , MEINHARDT G , SALEH L , et al . Self-renewing trophoblast organoids recapitulate the developmental program of the early human placenta [J ] . Stem Cell Reports , 2018 , 11 ( 2 ): 537 - 551 .

SHERIDAN M A , FERNANDO R C , GARDNER L , et al . Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta [J ] . Nature Protocols , 2020 , 15 ( 10 ): 3441 - 3463 .

YANG L H , LIANG P F , YANG H H , et al . Trophoblast organoids with physiological polarity model placental structure and function [J ] . Journal of Cell Science , 2024 , 137 ( 5 ): jcs261528 .

HORI T , OKAE H , SHIBATA S , et al . Trophoblast stem cell-based organoid models of the human placental barrier [J ] . Nature Communications , 2024 , 15 ( 1 ): 962 .

IO S , KABATA M , IEMURA Y , et al . Capturing human trophoblast development with naive pluripotent stem cells in vitro [J ] . Cell Stem Cell , 2021 , 28 ( 6 ): 1023 - 1039.e13 .

SONCIN F , MOREY R , BUI T , et al . Derivation of functional trophoblast stem cells from primed human pluripotent stem cells [J ] . Stem Cell Reports , 2022 , 17 ( 6 ): 1303 - 1317 .

HUANG L J , TU Z W , WEI L D , et al . Generating functional multicellular organoids from human placenta villi [J ] . Advanced Science , 2023 , 10 ( 26 ): e2301565 .

CUI K L , ZHU Y J , SHI Y , et al . Establishment of trophoblast-like tissue model from human pluripotent stem cells in three-dimensional culture system [J ] . Advanced Science , 2022 , 9 ( 3 ): e2100031 .

DENG P W , CUI K L , SHI Y , et al . Fluidic flow enhances the differentiation of placental trophoblast-like 3D tissue from hiPSCs in a perfused macrofluidic device [J ] . Frontiers in Bioengineering and Biotechnology , 2022 , 10 : 907104 .

TURCO M Y , GARDNER L , HUGHES J , et al . Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium [J ] . Nature Cell Biology , 2017 , 19 ( 5 ): 568 - 577 .

MCCONKEY C A , DELORME-AXFORD E , NICKERSON C A , et al . A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance [J ] . Science Advances , 2016 , 2 ( 3 ): e1501462 .

LEVKOVITZ R , ZARETSKY U , GORDON Z , et al . In vitro simulation of placental transport: part Ⅰ. Biological model of the placental barrier [J ] . Placenta , 2013 , 34 ( 8 ): 699 - 707 .

LEVKOVITZ R , ZARETSKY U , JAFFA A J , et al . In vitro simulation of placental transport: part Ⅱ. Glucose transfer across the placental barrier model [J ] . Placenta , 2013 , 34 ( 8 ): 708 - 715 .

KUO C Y , ERANKI A , PLACONE J K , et al . Development of a 3D printed, bioengineered placenta model to evaluate the role of trophoblast migration in preeclampsia [J ] . ACS Biomaterials Science & Engineering , 2016 , 2 ( 10 ): 1817 - 1826 .

KUO C Y , GUO T , CABRERA-LUQUE J , et al . Placental basement membrane proteins are required for effective cytotrophoblast invasion in a three-dimensional bioprinted placenta model [J ] . Journal of Biomedical Materials Research Part A , 2018 , 106 ( 6 ): 1476 - 1487 .

KUO C Y , SHEVCHUK M , OPFERMANN J , et al . Trophoblast-endothelium signaling involves angiogenesis and apoptosis in a dynamic bioprinted placenta model [J ] . Biotechnology and Bioengineering , 2019 , 116 ( 1 ): 181 - 192 .

GOLDSTEIN J A , GALLAGHER K , BECK C , et al . Maternal-fetal inflammation in the placenta and the developmental origins of health and disease [J ] . Frontiers in Immunology , 2020 , 11 : 531543 .

HUPPERTZ B . The critical role of abnormal trophoblast development in the etiology of preeclampsia [J ] . Current Pharmaceutical Biotechnology , 2018 , 19 ( 10 ): 771 - 780 .

NIRUPAMA R , DIVYASHREE S , JANHAVI P , et al . Preeclampsia: pathophysiology and management [J ] . Journal of Gynecology Obstetrics and Human Reproduction , 2021 , 50 ( 2 ): 101975 .

MELCHIORRE K , GIORGIONE V , THILAGANATHAN B . The placenta and preeclampsia: villain or victim? [J ] . American Journal of Obstetrics and Gynecology , 2022 , 226 ( 2S ): S954 - S962 .

GHORBANPOUR S M , RICHARDS C , PIENAAR D , et al . A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia [J ] . Cellular and Molecular Life Sciences , 2023 , 80 ( 2 ): 44 .

ROMBERG S I , KREIS N N , FRIEMEL A , et al . Human placental mesenchymal stromal cells are ciliated and their ciliation is compromised in preeclampsia [J ] . BMC Medicine , 2022 , 20 ( 1 ): 35 .

ARUMUGASAAMY N , ETTEHADIEH L E , KUO C Y , et al . Biomimetic placenta-fetus model demonstrating maternal-fetal transmission and fetal neural toxicity of zika virus [J ] . Annals of Biomedical Engineering , 2018 , 46 ( 12 ): 1963 - 1974 .

KARVAS R M , KHAN S A , VERMA S , et al . Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens [J ] . Cell Stem Cell , 2022 , 29 ( 5 ): 810 - 825.e8 .

RAGER J E , BANGMA J , CARBERRY C , et al . Review of the environmental prenatal exposome and its relationship to maternal and fetal health [J ] . Reproductive Toxicology , 2020 , 98 : 1 - 12 .

MANANGAMA G , MIGAULT L , AUDIGNON-DURAND S , et al . Maternal occupational exposures to nanoscale particles and small for gestational age outcome in the French Longitudinal Study of Children [J ] . Environment International , 2019 , 122 : 322 - 329 .

MUOTH C , WICHSER A , MONOPOLI M , et al . A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment [J ] . Nanoscale , 2016 , 8 ( 39 ): 17322 - 17332 .

SCHULLER P , ROTHBAUER M , KRATZ S R A , et al . A lab-on-a-chip system with an embedded porous membrane-based impedance biosensor array for nanoparticle risk assessment on placental Bewo trophoblast cells [J ] . Sensors and Actuators B: Chemical , 2020 , 312 : 127946 .

GINGRICH J , TICIANI E , VEIGA-LOPEZ A . Placenta disrupted: endocrine disrupting chemicals and pregnancy [J ] . Trends in Endocrinology and Metabolism , 2020 , 31 ( 7 ): 508 - 524 .

TICIANI E , PU Y , GINGRICH J , et al . Bisphenol S impairs invasion and proliferation of extravillous trophoblasts cells by interfering with epidermal growth factor receptor signaling [J ] . International Journal of Molecular Sciences , 2022 , 23 ( 2 ): 671 .

XU C K , MA H J , GAO F M , et al . Screening of organophosphate flame retardants with placentation-disrupting effects in human trophoblast organoid model and characterization of adverse pregnancy outcomes in mice [J ] . Environmental Health Perspectives , 2022 , 130 ( 5 ): 57002 .

YAMASHITA M , MARKERT U R . Overview of drug transporters in human placenta [J ] . International Journal of Molecular Sciences , 2021 , 22 ( 23 ): 13149 .

PEMATHILAKA R L , ALIMORADI N , REYNOLDS D E , et al . Transport of maternally administered pharmaceutical agents across the placental barrier in vitro [J ] . ACS Applied Bio Materials , 2022 , 5 ( 5 ): 2273 - 2284 .

RICHARDSON L S , KAMMALA K A , COSTANTINE M M , et al . Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy [J ] . Lab on a Chip , 2022 , 22 ( 23 ): 4574 - 4592 .