醇脱氢酶的研究进展及其催化增值生物基呋喃化合物前景展望

刘庠诗; 吴奕禄; 詹鹏; 黄天灏; 蔡的; 秦培勇

doi:10.12211/2096-8280.2023-059

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醇脱氢酶的研究进展及其催化增值生物基呋喃化合物前景展望

特约评述 | 更新时间：2025-03-20

- 醇脱氢酶的研究进展及其催化增值生物基呋喃化合物前景展望
- State-of-the-art for alcohol dehydrogenase development and the prospect of its applications in bio-based furan compounds valorization
- 合成生物学 2023年4卷第6期页码：1122-1139
- 作者机构：
  
  1.北京化工大学，国家能源生物炼制研发中心，北京 100029
  2.北京化工大学，生命科学与技术学院，北京 100029
- 作者简介：
  
  [ "刘庠诗（2000—），女，硕士研究生。研究方向为光/电-生物催化生物基平台化合物合成。E-mail：lxs20000417@163.com" ]
  [ "蔡的（1989—），男，副教授。研究方向主要为绿色生物制造。E-mail：caidibuct@163.com" ]
  [ "秦培勇（1976—），男，教授。研究方向主要为生物化工和膜分离等。E-mail：qinpy@mail.buct.edu.cn" ]
- 基金信息：
  
  国家自然科学基金(22078018);北京自然科学基金(2222016)
- DOI：10.12211/2096-8280.2023-059
  中图分类号： Q554+.1
- 收稿：2023-08-21，
  
  修回：2023-10-17，
  
  纸质出版：2023-12-31
- 稿件说明：
移动端阅览
刘庠诗，吴奕禄，詹鹏，黄天灏，蔡的，秦培勇. 醇脱氢酶的研究进展及其催化增值生物基呋喃化合物前景展望［J］. 合成生物学， 2023， 4（6）： 1122-1139

LIU Xiangshi， WU Yilu， ZHAN Peng， HUANG Tianhao， CAI Di， QIN Peiyong. State-of-the-art for alcohol dehydrogenase development and the prospect of its applications in bio-based furan compounds valorization［J］. Synthetic Biology Journal， 2023， 4（6）： 1122-1139
刘庠诗，吴奕禄，詹鹏，黄天灏，蔡的，秦培勇. 醇脱氢酶的研究进展及其催化增值生物基呋喃化合物前景展望［J］. 合成生物学， 2023， 4（6）： 1122-1139 DOI： 10.12211/2096-8280.2023-059.

LIU Xiangshi， WU Yilu， ZHAN Peng， HUANG Tianhao， CAI Di， QIN Peiyong. State-of-the-art for alcohol dehydrogenase development and the prospect of its applications in bio-based furan compounds valorization［J］. Synthetic Biology Journal， 2023， 4（6）： 1122-1139 DOI： 10.12211/2096-8280.2023-059.

摘要

醇脱氢酶（alcohol dehydrogenase， ADH）广泛存在于生物体内，可应用于多种有机物选择性氧化还原。近年来，随着对酶的催化机理、结构认知、分子改造和反应系统构建及强化等方面研究的逐渐深入，ADH在生物基平台化合物的高选择性催化氧化还原方面展现出巨大潜力。本文综述了ADH分子设计和定向改造的前沿技术和进展，面向常见的辅因子依赖性ADH催化过程中的辅因子高成本及稳定性差等局限，聚焦酶反应过程中的辅因子再生强化技术，梳理了适用于ADH催化系统的化学驱动、酶驱动和光电驱动辅因子再生路径，并从单酶催化体系开发、多酶协同催化系统挖掘、全细胞催化技术发展与应用等多个角度概述了ADH在催化生物基呋喃化合物方向的最新研究进展。随着对ADH应用潜力的进一步挖掘，未来ADH有望成为生物基呋喃增值工业化进程中的重要组成部分，为能源生产的绿色发展提供助力。

Abstract

Alcohol dehydrogenase (ADH) is found widely in living cells

where it catalyzes the oxidation or reduction between hydroxyl group and carbonyl group. It also catalyzes redox reactions of a variety of organic compounds with high selectivity. In recent years

with the research progress of the catalytic mechanism

structural information

molecular modification

and reaction systems

ADH has shown great promise in the highly selective catalysis of various bio-based platform compounds. One example is the oxidation or reduction of furan derivatives such as furfural and 5-hydroxymethylfurfural

which are important sustainable building blocks for bio-jet fuels and biomaterials that are derived from tandem hydrolysis

isomerization

and dehydration of hemicelluloses and celluloses fractions in lignocellulose matrixes. This review focuses on the cutting-edge technologies in molecular design and directional engineering of ADH. In addition

the intensification of cofactor regeneration processes

including chemical-driven

enzyme-driven

and photo/electricity-driven pathways were also summarized. These methods could be the solutions to the negative aspects

such as expensive cost

poor stability

and the poor circulating efficiency of the nicotinamide cofactors that are indispensable assisted in typical ADH catalysis process. Moreover

the latest research progresses of ADH in catalysis of bio-based furans platform chemicals were also discussed. Apart from using ADH solely for the activation of the hydroxyl and carbonyl groups in the biobased furan derivates and the production of oxidative and reductive products

there is also of great promise in cascade ADH catalysis and other chemical or biological ca

talysis processes in one-pot under relatively mild conditions to valorize the furan derivates into valuable fine chemicals. Meanwhile

the whole-cell catalytic process that involves ADH and

in vivo

cofactors regeneration also possesses potentials in biobased furans valorization

with the advantages of low catalyst loading and processing costs. Overall

the researches of ADH in catalysis biological furans valorization has entered a new stage. With the further exploration of the potential applications of ADH

its role in the transformation of biomass resources will be increasingly important

particularly in the industrial process in the future.

关键词

Keywords

references

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