二氧化碳微生物转化与体外酶催化体系研究进展

叶伟; 李芮; 姜卫红; 顾阳

doi:10.12211/2096-8280.2023-050

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二氧化碳微生物转化与体外酶催化体系研究进展

特约评述 | 更新时间：2025-03-20

- 二氧化碳微生物转化与体外酶催化体系研究进展
- Microbial conversion and in vitro enzymatic catalysis for carbon dioxide utilization: a review
- 合成生物学 2023年4卷第6期页码：1223-1245
- 作者机构：
  
  1.中国科学院分子植物科学卓越创新中心，中国科学院合成生物学重点实验室，上海 200032
  2.河南大学生命科学学院，河南开封 475004
- 作者简介：
  
  [ "叶伟（1995—），男，实验师。研究方向为微生物代谢调控与代谢工程。E-mail：wye@cemps.ac.cn" ]
  [ "李芮（2001—），女，硕士研究生。研究方向为微生物代谢调控与代谢工程。E-mail：lirui21@cemps.ac.cn" ]
  [ "顾阳（1977—），男，研究员。研究方向为一碳生物转化。E-mail：ygu@cemps.ac.cn" ]
- 基金信息：
  
  国家重点研发计划(2018YFA0901500);上海市科学技术委员会科研计划项目(21DZ1209100);中国科学院洁净能源创新研究院合作基金项目(DNL202013)
- DOI：10.12211/2096-8280.2023-050
  中图分类号： Q819
- 收稿：2023-07-11，
  
  修回：2023-09-18，
  
  纸质出版：2023-12-31
- 稿件说明：
移动端阅览
叶伟，李芮，姜卫红，顾阳. 二氧化碳微生物转化与体外酶催化体系研究进展［J］. 合成生物学， 2023， 4（6）： 1223-1245

YE Wei， LI Rui， JIANG Weihong， GU Yang. Microbial conversion and in vitro enzymatic catalysis for carbon dioxide utilization： a review［J］. Synthetic Biology Journal， 2023， 4（6）： 1223-1245
叶伟，李芮，姜卫红，顾阳. 二氧化碳微生物转化与体外酶催化体系研究进展［J］. 合成生物学， 2023， 4（6）： 1223-1245 DOI： 10.12211/2096-8280.2023-050.

YE Wei， LI Rui， JIANG Weihong， GU Yang. Microbial conversion and in vitro enzymatic catalysis for carbon dioxide utilization： a review［J］. Synthetic Biology Journal， 2023， 4（6）： 1223-1245 DOI： 10.12211/2096-8280.2023-050.

摘要

二氧化碳（CO

）是主要的温室气体，但同时也是一种储量巨大、廉价、安全且易得的可再生资源。在我国“碳达峰、碳中和”战略目标的驱动下，如何有效减少CO

排放并转而利用这一重要碳资源已成为当前的研究热点与重点，这同时也加快了CO

捕集、利用与封存（carbon capture， utilization and storage， CCUS）技术的发展和创新。生物转化是实现CO

利用的主要路径之一，既能够直接催化、转化CO

合成目标产物，也可以与化学催化路径相耦合实现对CO

来源的有机低碳资源（如甲醇、甲酸、乙酸）的有效转化及定向合成，因此有望在国家“双碳”目标的实现中发挥重要作用。本文对近年来CO

生物转化的研究进展进行了梳理和总结，指出了现有技术路线的特点和不足，并对今后的研究重点和方向提出了建议。总体而言，CO

生物利用技术目前尚处于起步阶段。基于化能自养细菌的合成气（CO

/CO）发酵生产乙醇虽已实现工业化，但仍需要进一步优化和提高CO

的转化利用效率，并获得除乙醇外更多的高值产品，从而提升整个技术路线的经济性。而其他的CO

生物转化路径，无论是化学-生物发酵耦合还是体外酶催化，目前离大规模应用还有较大距离，需要进一步优化技术体系和降低成本来满足工业化需求。

Abstract

Carbon dioxide (CO

) is the main greenhouse gas

but it also represents an abundant

cost-effective

safe

and easily accessible carbon resource. Driven by the national goals to achieve "carbon peaking and carbon neutrality"

there has been an increasing interest in recent years in effective reduction of CO

emission and utilization of this one-carbon resource

thereby accelerating the development of carbon capture

utilization

and storage (CCUS) technologies. Biological conversion plays a major role in CCUS. This approach enables the transformation of CO

into desired products through either direct biological catalysis or in combination with chemical catalysis (using CO

-derived organic compounds such as methanol

formic acid

and acetic acid). Thus

biological CO

fixation and conversion represents a promising solution for both utilization of greenhouse gas or industrial waste gases and sustainable production of bulk chemicals and fuels. However

the current state of biotransformation technology for CCUS is still in its infancy

leaving ample room for improvement in the efficiency

yield

and cost-effectiveness. In this review

we briefly summarize recent advances in biological utilization of CO

highlight the characteristics and limitations of the existing technologies

and also propose future research directions. Our aim is to provide a valuable reference to researchers in this field. Overall

industrial application of CO

bioconversion remains in its nascent phase. Although industrial-scale ethanol production through syngas (CO

/CO) fermentation by chemoautotrophic bacteria has made significant strides

there is still a need for further improvement in the conversion efficiency of CO

. In addition

gas fermentation should consider more value-added products beyond ethanol to enhance the economic viability of this technology. Other CO

bioutilization technologies

such as the coupling of chemical

and biological conversion and in vitro enzymatic catalysis

have yet to bridge the gap to large-scale applications. Therefore

further optimization of these technical systems and reduction of production cost are essential to meet the needs of industrial applications.

关键词

Keywords

references

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