WEAVER S C , REISEN W K . Present and future arboviral threats [J ] . Antiviral Research , 2010 , 85 ( 2 ): 328 - 345 .

WEAVER S C , BARRETT A D T . Transmission cycles, host range, evolution and emergence of arboviral disease [J ] . Nature Reviews Microbiology , 2004 , 2 ( 10 ): 789 - 801 .

BHATT S , GETHING P W , BRADY O J , et al . The global distribution and burden of dengue [J ] . Nature , 2013 , 496 ( 7446 ): 504 - 507 .

GAO G F . From "A"IV to "Z"IKV: attacks from emerging and re-emerging pathogens [J ] . Cell , 2018 , 172 ( 6 ): 1157 - 1159 .

PIERSON T C , DIAMOND M S . The emergence of Zika virus and its new clinical syndromes [J ] . Nature , 2018 , 560 ( 7720 ): 573 - 581 .

GOULD E A , SOLOMON T . Pathogenic flaviviruses [J ] . Lancet , 2008 , 371 ( 9611 ): 500 - 509 .

HEGDE N R , GORE M M . Japanese encephalitis vaccines: immunogenicity, protective efficacy, effectiveness, and impact on the burden of disease [J ] . Human Vaccines & Immunotherapeutics , 2017 , 13 ( 6 ): 1320 - 1337 .

ROEHRIG J T . West Nile virus in the United States - a historical perspective [J ] . Viruses , 2013 , 5 ( 12 ): 3088 - 3108 .

COLLINS M H , METZ S W . Progress and works in progress: update on flavivirus vaccine development [J ] . Clinical Therapeutics , 2017 , 39 ( 8 ): 1519 - 1536 .

SCHERWITZL I , MONGKOLSAPAJA J , SCREATON G . Recent advances in human flavivirus vaccines [J ] . Current Opinion in Virology , 2017 , 23 : 95 - 101 .

SIMMONDS P , BECHER P , BUKH J , et al . ICTV virus taxonomy profile: Flaviviridae [J ] . The Journal of General Virology , 2017 , 98 ( 1 ): 2 - 3 .

BURKE D S , MONATH T P . Flavivirus [M ] // KNIPE D M and HOWLEY P M . Field virology, 4th ed. Philadelphia : Lippincott Williams & Wilkins , 2001 : 852 - 921 .

KOSTYUCHENKO V A , LIM E X Y , ZHANG S J , et al . Structure of the thermally stable Zika virus [J ] . Nature , 2016 , 533 ( 7603 ): 425 - 428 .

BYK L A , GAMARNIK A V . Properties and functions of the dengue virus capsid protein [J ] . Annual Review of Virology , 2016 , 3 ( 1 ): 263 - 281 .

MUKHOPADHYAY S , KUHN R J , ROSSMANN M G . A structural perspective of the flavivirus life cycle [J ] . Nature Reviews Microbiology , 2005 , 3 ( 1 ): 13 - 22 .

FALGOUT B , PETHEL M , ZHANG Y M , et al . Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins [J ] . Journal of Virology , 1991 , 65 ( 5 ): 2467 - 2475 .

PERERA R , KUHN R J . Structural proteomics of dengue virus [J ] . Current Opinion in Microbiology , 2008 , 11 ( 4 ): 369 - 377 .

WESTAWAY E G , MACKENZIE J M , KHROMYKH A A . Kunjin RNA replication and applications of Kunjin replicons [J ] . Advances in Virus Research , 2003 , 59 : 99 - 140 .

LORENZ I C , ALLISON S L , HEINZ F X , et al . Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulum [J ] . Journal of Virology , 2002 , 76 ( 11 ): 5480 - 5491 .

KELLY E P , GREENE J J , KING A D , et al . Purified dengue 2 virus envelope glycoprotein aggregates produced by baculovirus are immunogenic in mice [J ] . Vaccine , 2000 , 18 ( 23 ): 2549 - 2559 .

ZHANG Y , CORVER J , CHIPMAN P R , et al . Structures of immature flavivirus particles [J ] . The EMBO Journal , 2003 , 22 ( 11 ): 2604 - 2613 .

YU I M , ZHANG W , HOLDAWAY H A , et al . Structure of the immature dengue virus at low pH primes proteolytic maturation [J ] . Science , 2008 , 319 ( 5871 ): 1834 - 1837 .

LORENZ I C , KARTENBECK J , MEZZACASA A , et al . Intracellular assembly and secretion of recombinant subviral particles from tick-borne encephalitis virus [J ] . Journal of Virology , 2003 , 77 ( 7 ): 4370 - 4382 .

FARIA N R , KRAEMER M G , HILL S C , et al . Genomic and epidemiological monitoring of yellow fever virus transmission potential [J ] . Science , 2018 , 361 ( 6405 ): 894 - 899 .

INGELBEEN B , WEREGEMERE N A , NOEL H , et al . Urban yellow fever outbreak-Democratic Republic of the Congo, 2016: towards more rapid case detection [J ] . PLoS Neglected Tropical Diseases , 2018 , 12 ( 12 ): e0007029 .

LING Y , CHEN J , HUANG Q , et al . Yellow fever in a worker returning to China from Angola, March 2016 [J ] . Emerging Infectious Diseases , 2016 , 22 ( 7 ): 1317 - 1318 .

YOUNG P . Arboviruses: a family on the move [M ] // HILGENFELD R, VASUDEVAN S G. Dengue and Zika: control and antiviral treatment strategies . Singapore : Springer , 2018 : 1 - 10 .

TABACHNICK W J . Climate change and the arboviruses: lessons from the evolution of the dengue and yellow fever viruses [J ] . Annual Review of Virology , 2016 , 3 ( 1 ): 125 - 145 .

MANSFIELD K L , HERNÁNDEZ-TRIANA L M , BANYARD A C , et al . Japanese encephalitis virus infection, diagnosis and control in domestic animals [J ] . Veterinary Microbiology , 2017 , 201 : 85 - 92 .

MCLEAN R G , UBICO S R , BOURNE D , et al . West Nile virus in livestock and wildlife [M ] //MACKENZIE J, BARRETT A, DEUBEL V eds. Japanese encephalitis and West Nile viruses . 2002 , 267 : 271 - 308 .

VENTER M . Assessing the zoonotic potential of arboviruses of African origin [J ] . Current Opinion in Virology , 2018 , 28 : 74 - 84 .

ZHANG W , CHEN S , MAHALINGAM S , et al . An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus [J ] . The Journal of General Virology , 2017 , 98 ( 10 ): 2413 - 2420 .

PANDIT P S , DOYLE M M , SMART K M , et al . Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses [J ] . Nature Communications , 2018 , 9 : 5425 .

WHO . Global strategy for dengue prevention and control 2012 - 2020 [EB/OL ] .[ 2022-12-01 ] . https://apps.who.int/iris/bitstream/handle/10665/75303/9789241504034_eng.pdf;jsessionid=F594B0 B8ED14E465810AE5871FE084F6?sequence=1 https://apps.who.int/iris/bitstream/handle/10665/75303/9789241504034_eng.pdf;jsessionid=F594B0B8ED14E465810AE5871FE084F6?sequence=1 .

GUO C C , ZHOU Z X , WEN Z H , et al . Global epidemiology of dengue outbreaks in 1990—2015: a systematic review and meta-analysis [J ] . Frontiers in Cellular and Infection Microbiology , 2017 , 7 : 317 .

STRUCHINER C J , ROCKLÖV J , WILDER-SMITH A , et al . Increasing dengue incidence in Singapore over the past 40 years: population growth, climate and mobility [J ] . PLoS One , 2015 , 10 ( 8 ): e0136286 .

BRATHWAITE DICK O , SAN MARTÍN J L , MONTOYA R H , et al . The history of dengue outbreaks in the americas [J ] . The American Journal of Tropical Medicine and Hygiene , 2012 , 87 ( 4 ): 584 - 593 .

DHIMAL M , GAUTAM I , JOSHI H D , et al . Risk factors for the presence of chikungunya and dengue vectors ( Aedes aegypti and Aedes albopictus ), their altitudinal distribution and climatic determinants of their abundance in central Nepal [J ] . PLoS Neglected Tropical Diseases , 2015 , 9 ( 3 ): e0003545 .

PANDEY B D , RAI S K , MORITA K , et al . First case of Dengue virus infection in Nepal [J ] . Nepal Medical College Journal: NMCJ , 2004 , 6 ( 2 ): 157 - 159 .

MALLA S , THAKUR G D , SHRESTHA S K , et al . Identification of all dengue serotypes in Nepal [J ] . Emerging Infectious Diseases , 2008 , 14 ( 10 ): 1669 - 1670 .

YANG L , CHEN Y , YAN H C , et al . A survey of the 2014 dengue fever epidemic in Guangzhou, China [J ] . Emerging Microbes & Infections , 2015 , 4 ( 9 ): e57 .

KOBAYASHI D , MUROTA K , FUJITA R , et al . Dengue virus infection in Aedes albopictus during the 2014 autochthonous dengue outbreak in Tokyo metropolis, Japan [J ] . The American Journal of Tropical Medicine and Hygiene , 2018 , 98 ( 5 ): 1460 - 1468 .

関なおみ , 岩下裕子 , 本涼子 , ほか . 東京都におけるデング熱国内感染事例の発生について [J/OL ] . 日本公衆衛生雑誌 , 2015 , 62 ( 5 ): 238 - 250 [ 2022-12-01 ] . https://www.jstage.jst.go.jp/article/jph/62/5/62_14-102/_article/-char/ja/ https://www.jstage.jst.go.jp/article/jph/62/5/62_14-102/_article/-char/ja/ .

SEKI N , IWASHITA Y , MOTO R , et al . An autochthonous outbreak of dengue type 1 in Tokyo, Japan 2014 [J/OL ] . Japanese Journal of Public Health , 2015 , 62 ( 5 ): 238 - 250 [ 2022-12-01 ] . https://www.jstage.jst.go.jp/article/jph/62/5/62_14-102/_article/-char/ja/ https://www.jstage.jst.go.jp/article/jph/62/5/62_14-102/_article/-char/ja/ .

DUCHEYNE E , TRAN MINH N N , HADDAD N , et al . Current and future distribution of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in WHO Eastern Mediterranean Region [J ] . International Journal of Health Geographics , 2018 , 17 ( 1 ): 4 .

SUCCO T , LEPARC-GOFFART I , FERRÉ J B , et al . Autochthonous dengue outbreak in Nîmes, south of France, July to September 2015 [J ] . Eurosurveillance , 2016 , 21 ( 21 ): pii=30240 .

DUFFY M R , CHEN T H , HANCOCK W T , et al . Zika virus outbreak on Yap Island, Federated States of Micronesia [J ] . The New England Journal of Medicine , 2009 , 360 ( 24 ): 2536 - 2543 .

FOY B D , KOBYLINSKI K C , FOY J L C , et al . Probable non-vector-borne transmission of Zika virus, Colorado, USA [J ] . Emerging Infectious Diseases , 2011 , 17 ( 5 ): 880 - 882 .

KURSCHEIDT F A , MESQUITA C S S , DAMKE G M Z F , et al . Persistence and clinical relevance of Zika virus in the male genital tract [J ] . Nature Reviews Urology , 2019 , 16 ( 4 ): 211 - 230 .

OEHLER E , WATRIN L , LARRE P , et al . Zika virus infection complicated by Guillain-Barre syndrome — case report, French Polynesia, December 2013 [J ] . Euro Surveillance , 2014 , 19 ( 9 ): 20720 .

HALSTEAD S B . Chapter 3-Chikungunya and Zika Disease [M/OL ] // Chikungunya and Zika Viruses . HIGGS S, VANLANDINGHAM D L, POWERS A M, ed. Pittsburgh: Academic Press, 2018 : 69 - 85 [2022-12-01] . https://www.sciencedirect.com/science/article/pii/B9780128118658000039 https://www.sciencedirect.com/science/article/pii/B9780128118658000039 .

VALIANT W G , LALANI T , YUN H C , et al . Human serum with high neutralizing antibody titers against both Zika and dengue virus shows delayed in vitro antibody-dependent enhancement of dengue virus infection [J ] . Open Forum Infectious Diseases , 2018 , 5 ( 7 ): ofy151 .

BRYANT J E , HOLMES E C , BARRETT A D T . Out of Africa: a molecular perspective on the introduction of yellow fever virus into the Americas [J ] . PLoS Pathogens , 2007 , 3 ( 5 ): e75 .

VAN DER STUYFT P , GIANELLA A , PIRARD M , et al . Urbanisation of yellow fever in Santa Cruz, Bolivia [J ] . Lancet , 1999 , 353 ( 9164 ): 1558 - 1562 .

BARRETT A D T . Yellow fever live attenuated vaccine: a very successful live attenuated vaccine but still we have problems controlling the disease [J ] . Vaccine , 2017 , 35 ( 44 ): 5951 - 5955 .

SHEARER F M , MOYES C L , PIGOTT D M , et al . Global yellow fever vaccination coverage from 1970 to 2016: an adjusted retrospective analysis [J ] . The Lancet Infectious Diseases , 2017 , 17 ( 11 ): 1209 - 1217 .

GARSKE T , VAN KERKHOVE M D , YACTAYO S , et al . Yellow fever in Africa: estimating the burden of disease and impact of mass vaccination from outbreak and serological data [J ] . PLoS Medicine , 2014 , 11 ( 5 ): e1001638 .

MONATH T P , VASCONCELOS P F C . Yellow fever [J ] . Journal of Clinical Virology , 2015 , 64 : 160 - 173 .

BARRETT A D T . Yellow fever in Angola and beyond — the problem of vaccine supply and demand [J ] . The New England Journal of Medicine , 2016 , 375 ( 4 ): 301 - 303 .

CASEY R M , HARRIS J B , AHUKA-MUNDEKE S , et al . Immunogenicity of fractional-dose vaccine during a yellow fever outbreak - final report [J ] . The New England Journal of Medicine , 2019 , 381 ( 5 ): 444 - 454 .

ZHENG Y Y , LI M H , WANG H Y , et al . Japanese encephalitis and Japanese encephalitis virus in mainland China [J ] . Reviews in Medical Virology , 2012 , 22 ( 5 ): 301 - 322 .

DE WISPELAERE M , DESPRÈS P , CHOUMET V . European Aedes albopictus and culex pipiens are competent vectors for Japanese encephalitis virus [J ] . PLoS Neglected Tropical Diseases , 2017 , 11 ( 1 ): e0005294 .

HUANG Y J S , HETTENBACH S M , PARK S L , et al . Differential infectivities among different Japanese encephalitis virus genotypes in Culex quinquefasciatus mosquitoes [J ] . PLoS Neglected Tropical Diseases , 2016 , 10 ( 10 ): e0005038 .

SCHUH A J , WARD M J , LEIGH BROWN A J , et al . Dynamics of the emergence and establishment of a newly dominant genotype of Japanese encephalitis virus throughout Asia [J ] . Journal of Virology , 2014 , 88 ( 8 ): 4522 - 4532 .

FAN Y C , LIN J W , LIAO S Y , et al . Virulence of Japanese encephalitis virus genotypesⅠandⅢ, Taiwan [J/OL ] . Emerging Infectious Diseases , 2017 , 23 ( 11 ): 1883 - 1886 [ 2022-12-01 ] . https://doi.org/10.3201/eid2311.161443 https://doi.org/10.3201/eid2311.161443 .

PARK S L , HUANG Y J S , LYONS A C , et al . North American domestic pigs are susceptible to experimental infection with Japanese encephalitis virus [J ] . Scientific Reports , 2018 , 8 : 7951 .

RICKLIN M E , GARCÌA-NICOLÀS O , BRECHBÜHL D , et al . Japanese encephalitis virus tropism in experimentally infected pigs [J ] . Veterinary Research , 2016 , 47 : 34 .

SUNWOO J S , JUNG K H , LEE S T , et al . Reemergence of Japanese encephalitis in South Korea, 2010-2015 [J ] . Emerging Infectious Diseases , 2016 , 22 ( 10 ): 1841 - 1843 .

HEFFELFINGER J D , LI X , BATMUNKH N , et al . Japanese encephalitis surveillance and immunization-Asia and Western Pacific regions, 2016 [J ] . MMWR Morbidity and Mortality Weekly Report , 2017 , 66 ( 22 ): 579 - 583 .

NEMETH N , BOSCO-LAUTH A , OESTERLE P , et al . North American birds as potential amplifying hosts of Japanese encephalitis virus [J ] . The American Journal of Tropical Medicine and Hygiene , 2012 , 87 ( 4 ): 760 - 767 .

LYONS A C , HUANG Y J S , PARK S L , et al . Shedding of Japanese encephalitis virus in oral fluid of infected swine [J ] . Vector Borne and Zoonotic Diseases , 2018 , 18 ( 9 ): 469 - 474 .

RICKLIN M E , GARCÍA-NICOLÁS O , BRECHBÜHL D , et al . Vector-free transmission and persistence of Japanese encephalitis virus in pigs [J ] . Nature Communications , 2016 , 7 : 10832 .

CDC . West Nile virus final cumulative maps & data for 1999 - 2021 [EB/OL ] .[ 2023-01-10 ] . https://www.cdc.gov/westnile/statsmaps/cumMapsData.html https://www.cdc.gov/westnile/statsmaps/cumMapsData.html .

PETERSEN L R , BRAULT A C , NASCI R S . West Nile virus: review of the literature [J ] . JAMA , 2013 , 310 ( 3 ): 308 - 315 .

DAVIS C T , EBEL G D , LANCIOTTI R S , et al . Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: evidence for the emergence of a dominant genotype [J ] . Virology , 2005 , 342 ( 2 ): 252 - 265 .

MAY F J , DAVIS C T , TESH R B , et al . Phylogeography of West Nile virus: from the cradle of evolution in Africa to Eurasia, Australia, and the Americas [J ] . Journal of Virology , 2011 , 85 ( 6 ): 2964 - 2974 .

REITER P . West Nile virus in Europe: understanding the present to gauge the future [J ] . Euro Surveillance , 2010 , 15 ( 10 ): 19508 .

GUBLER D J , TRENT D W . Emergence of epidemic dengue/dengue hemorrhagic fever as a public health problem in the Americas [J ] . Infectious Agents and Disease , 1993 , 2 ( 6 ): 383 - 393 .

GUBLER D J , NALIM S , TAN R , et al . Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti [J ] . The American Journal of Tropical Medicine and Hygiene , 1979 , 28 ( 6 ): 1045 - 1052 .

GUBLER D J , ROSEN L . Variation among geographic strains of Aedes albopictus in susceptibility to infection with dengue viruses [J ] . The American Journal of Tropical Medicine and Hygiene , 1976 , 25 ( 2 ): 318 - 325 .

RICO-HESSE R . Molecular evolution and distribution of dengue viruses type 1 and 2 in nature [J ] . Virology , 1990 , 174 ( 2 ): 479 - 493 .

RUDNICK A . Studies of the ecology of dengue in Malaysia: a preliminary report [J ] . Journal of Medical Entomology , 1965 , 2 ( 2 ): 203 - 208 .

RUDNICK A , MARCHETTE N J , GARCIA R . Possible jungle dengue — recent studies and hypotheses [J ] . Japanese Journal of Medical Science & Biology , 1967 , 20 Suppl : 69 - 74 .

ZHU Y B , ZHANG R D , ZHANG B , et al . Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system [J ] . Nature Communications , 2017 , 8 : 1262 .

SOUZA-NETO J A , POWELL J R , BONIZZONI M . Aedes aegypti vector competence studies: a review [J ] . Infection, Genetics and Evolution , 2019 , 67 : 191 - 209 .

ROUNDY C M , AZAR S R , ROSSI S L , et al . Variation in Aedes aegypti mosquito competence for Zika virus transmission [J ] . Emerging Infectious Diseases , 2017 , 23 ( 4 ): 625 - 632 .

CHENG G , LIU Y , WANG P H , et al . Mosquito defense strategies against viral infection [J ] . Trends in Parasitology , 2016 , 32 ( 3 ): 177 - 186 .

FRANZ A W E , KANTOR A M , PASSARELLI A L , et al . Tissue barriers to arbovirus infection in mosquitoes [J ] . Viruses , 2015 , 7 ( 7 ): 3741 - 3767 .

STYER L M , KENT K A , ALBRIGHT R G , et al . Mosquitoes inoculate high doses of West Nile virus as they probe and feed on live hosts [J ] . PLoS Pathogens , 2007 , 3 ( 9 ): 1262 - 1270 .

SANCHEZ-VARGAS I , HARRINGTON L C , BLACK W C Ⅳ , et al . Analysis of salivary glands and saliva from Aedes albopictus and Aedes aegypti infected with chikungunya viruses [J ] . Insects , 2019 , 10 ( 2 ): 39 .

DU S Y , LIU Y , LIU J Y , et al . Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments [J ] . Nature Communications , 2019 , 10 : 1324 .

MACIEL-DE-FREITAS R , CODEÇO C T , LOURENÇO-DE-OLIVEIRA R . Daily survival rates and dispersal of Aedes aegypti females in Rio de Janeiro, Brazil [J ] . The American Journal of Tropical Medicine and Hygiene , 2007 , 76 ( 4 ): 659 - 665 .

WHITEHORN J , KIEN D T H , NGUYEN N M , et al . Comparative susceptibility of Aedes albopictus and Aedes aegypti to dengue virus infection after feeding on blood of viremic humans: implications for public health [J ] . The Journal of Infectious Diseases , 2015 , 212 ( 8 ): 1182 - 1190 .

BARROWS N J , CAMPOS R K , LIAO K C , et al . Biochemistry and molecular biology of flaviviruses [J ] . Chemical Reviews , 2018 , 118 ( 8 ): 4448 - 4482 .

CHENG G , COX J , WANG P H , et al . A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes [J ] . Cell , 2010 , 142 ( 5 ): 714 - 725 .

LIU Y , ZHANG F C , LIU J Y , et al . Transmission-blocking antibodies against mosquito C-type lectins for dengue prevention [J ] . PLoS Pathogens , 2014 , 10 ( 2 ): e1003931 .

KUADKITKAN A , WIKAN N , FONGSARAN C , et al . Identification and characterization of prohibitin as a receptor protein mediating DENV-2 entry into insect cells [J ] . Virology , 2010 , 406 ( 1 ): 149 - 161 .

SALAS-BENITO J , REYES-DEL VALLE J , SALAS-BENITO M , et al . Evidence that the 45 kD glycoprotein, part of a putative dengue virus receptor complex in the mosquito cell line C6/36, is a heat-shock related protein [J ] . The American Journal of Tropical Medicine and Hygiene , 2007 , 77 ( 2 ): 283 - 290 .

SAKOONWATANYOO P , BOONSANAY V , SMITH D R . Growth and production of the dengue virus in C6/36 cells and identification of a laminin-binding protein as a candidate serotype 3 and 4 receptor protein [J ] . Intervirology , 2006 , 49 ( 3 ): 161 - 172 .

LONDONO-RENTERIA B , TROUPIN A , CONWAY M J , et al . Dengue virus infection of Aedes aegypti requires a putative cysteine rich venom protein [J ] . PLoS Pathogens , 2015 , 11 ( 10 ): e1005202 .

KAKUMANI P K , PONIA S S , S R K , et al . Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor [J ] . Journal of Virology , 2013 , 87 ( 16 ): 8870 - 8883 .

GÖERTZ G P , FROS J J , MIESEN P , et al . Noncoding subgenomic flavivirus RNA is processed by the mosquito RNA interference machinery and determines West Nile virus transmission by culex pipiens mosquitoes [J ] . Journal of Virology , 2016 , 90 ( 22 ): 10145 - 10159 .

MOON S L , DODD B J T , BRACKNEY D E , et al . Flavivirus sfRNA suppresses antiviral RNA interference in cultured cells and mosquitoes and directly interacts with the RNAi machinery [J ] . Virology , 2015 , 485 : 322 - 329 .

POMPON J , MANUEL M , NG G K , et al . Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission [J ] . PLoS Pathogens , 2017 , 13 ( 7 ): e1006535 .

PARIKH G R , OLIVER J D , BARTHOLOMAY L C . A haemocyte tropism for an arbovirus [J ] . The Journal of General Virology , 2009 , 90 ( Pt 2 ): 292 - 296 .

GOIC B , STAPLEFORD K A , FRANGEUL L , et al . Virus-derived DNA drives mosquito vector tolerance to arboviral infection [J ] . Nature Communications , 2016 , 7 : 12410 .

XIAO X P , ZHANG R D , PANG X J , et al . A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes [J ] . PLoS Pathogens , 2015 , 11 ( 4 ): e1004848 .

XIAO X P , LIU Y , ZHANG X Y , et al . Complement-related proteins control the flavivirus infection of Aedes aegypti by inducing antimicrobial peptides [J ] . PLoS Pathogens , 2014 , 10 ( 4 ): e1004027 .

BLANDIN S , SHIAO S H , MOITA L F , et al . Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae [J ] . Cell , 2004 , 116 ( 5 ): 661 - 670 .

SHOKAL U , ELEFTHERIANOS I . Evolution and function of thioester-containing proteins and the complement system in the innate immune response [J ] . Frontiers in Immunology , 2017 , 8 : 759 .

KINGSOLVER M B , HUANG Z J , HARDY R W . Insect antiviral innate immunity: pathways, effectors, and connections [J ] . Journal of Molecular Biology , 2013 , 425 ( 24 ): 4921 - 4936 .

TASSETTO M , KUNITOMI M , ANDINO R . Circulating immune cells mediate a systemic RNAi-based adaptive antiviral response in Drosophila [J ] . Cell , 2017 , 169 ( 2 ): 314 - 325.e13 .

GOIC B , VODOVAR N , MONDOTTE J A , et al . RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila [J ] . Nature Immunology , 2013 , 14 ( 4 ): 396 - 403 .

WU P , YU X , WANG P , et al . Arbovirus lifecycle in mosquito: acquisition, propagation and transmission [J ] . Expert Reviews in Molecular Medicine , 2019 , 21 : e1 .

RAMIREZ J L , SHORT S M , BAHIA A C , et al . Chromobacterium Csp_P reduces malaria and dengue infection in vector mosquitoes and has entomopathogenic and in vitro anti-pathogen activities [J ] . PLoS Pathogens , 2014 , 10 ( 10 ): e1004398 .

SARAIVA R G , FANG J R , KANG S , et al . Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein [J ] . PLoS Neglected Tropical Diseases , 2018 , 12 ( 4 ): e0006443 .

YU X , TONG L Q , ZHANG L M , et al . Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes [J ] . PLoS Pathogens , 2022 , 18 ( 6 ): e1010552 .

RAMIREZ J L , SOUZA-NETO J , TORRES COSME R , et al . Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota, innate immune system and dengue virus influences vector competence [J ] . PLoS Neglected Tropical Diseases , 2012 , 6 ( 3 ): e1561 .

APTE-DESHPANDE A , PAINGANKAR M , GOKHALE M D , et al . Serratia odorifera a midgut inhabitant of Aedes aegypti mosquito enhances its susceptibility to dengue-2 virus [J ] . PLoS One , 2012 , 7 ( 7 ): e40401 .

ANGLERÓ-RODRÍGUEZ Y I , TALYULI O A , BLUMBERG B J , et al . An Aedes aegypti -associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity [J ] . eLife , 2017 , 6 : e28844 .

DONG Y M , Jr MORTON J C , RAMIREZ J L , et al . The entomopathogenic fungus Beauveria bassiana activate toll and JAK-STAT pathway-controlled effector genes and anti-dengue activity in Aedes aegypti [J ] . Insect Biochemistry and Molecular Biology , 2012 , 42 ( 2 ): 126 - 132 .

GARZA-HERNÁNDEZ J A , RODRÍGUEZ-PÉREZ M A , SALAZAR M I , et al . Vectorial capacity of Aedes aegypti for dengue virus type 2 is reduced with co-infection of Metarhizium anisopliae [J ] . PLoS Neglected Tropical Diseases , 2013 , 7 ( 3 ): e2013 .

NGUYEN N M , THI HUE KIEN D , TUAN T V , et al . Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2013 , 110 ( 22 ): 9072 - 9077 .

WAGAR Z L , TREE M O , MPOY M C , et al . Low density lipopolyprotein inhibits flavivirus acquisition in Aedes aegypti [J ] . Insect Molecular Biology , 2017 , 26 ( 6 ): 734 - 742 .

BOTTINO-ROJAS V , TALYULI O A , JUPATANAKUL N , et al . Heme signaling impacts global gene expression, immunity and dengue virus infectivity in Aedes aegypti [J ] . PLoS One , 2015 , 10 ( 8 ): e0135985 .

LIU J Y , LIU Y , NIE K X , et al . Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes [J ] . Nature Microbiology , 2016 , 1 : 16087 .

LIU Y , LIU J Y , DU S Y , et al . Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes [J ] . Nature , 2017 , 545 ( 7655 ): 482 - 486 .

WU P , YU X , WANG P H , et al . Arbovirus lifecycle in mosquito: acquisition, propagation and transmission [J ] . Expert Reviews in Molecular Medicine , 2019 , 21 : e1 .

WICHIT S , DIOP F , HAMEL R , et al . Aedes aegypti saliva enhances chikungunya virus replication in human skin fibroblasts via inhibition of the typeⅠinterferon signaling pathway [J ] . Infection, Genetics and Evolution , 2017 , 55 : 68 - 70 .

CERNY D , HANIFFA M , SHIN A , et al . Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection [J ] . PLoS Pathogens , 2014 , 10 ( 12 ): e1004548 .

SCHMID M A , HARRIS E . Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for dengue virus replication [J ] . PLoS Pathogens , 2014 , 10 ( 12 ): e1004541 .

HAMEL R , DEJARNAC O , WICHIT S , et al . Biology of Zika virus infection in human skin cells [J ] . Journal of Virology , 2015 , 89 ( 17 ): 8880 - 8896 .

SCHAEFFER E , FLACHER V , PAPAGEORGIOU V , et al . Dermal CD14 + dendritic cell and macrophage infection by dengue virus is stimulated by interleukin-4 [J ] . The Journal of Investigative Dermatology , 2015 , 135 ( 7 ): 1743 - 1751 .

MACDONALD G H , JOHNSTON R E . Role of dendritic cell targeting in Venezuelan equine encephalitis virus pathogenesis [J ] . Journal of Virology , 2000 , 74 ( 2 ): 914 - 922 .

GARDNER C L , BURKE C W , TESFAY M Z , et al . Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis [J ] . Journal of Virology , 2008 , 82 ( 21 ): 10634 - 10646 .

DAVISON A M , KING N J C . Accelerated dendritic cell differentiation from migrating Ly6C(lo) bone marrow monocytes in early dermal West Nile virus infection [J ] . Journal of Immunology , 2011 , 186 ( 4 ): 2382 - 2396 .

WU S J L , GROUARD-VOGEL G , SUN W , et al . Human skin Langerhans cells are targets of dengue virus infection [J ] . Nature Medicine , 2000 , 6 ( 7 ): 816 - 820 .

DIAMOND M S , SHRESTHA B , MEHLHOP E , et al . Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus [J ] . Viral Immunology , 2003 , 16 ( 3 ): 259 - 278 .

STYER L M , LIM P Y , LOUIE K L , et al . Mosquito saliva causes enhancement of West Nile virus infection in mice [J ] . Journal of Virology , 2011 , 85 ( 4 ): 1517 - 1527 .

SCHNEIDER B S , SOONG L , GIRARD Y A , et al . Potentiation of West Nile encephalitis by mosquito feeding [J ] . Viral Immunology , 2006 , 19 ( 1 ): 74 - 82 .

COX J , MOTA J , SUKUPOLVI-PETTY S , et al . Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice [J ] . Journal of Virology , 2012 , 86 ( 14 ): 7637 - 7649 .

SCHNEIDER B S , HIGGS S . The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response [J ] . Transactions of the Royal Society of Tropical Medicine and Hygiene , 2008 , 102 ( 5 ): 400 - 408 .

PINGEN M , SCHMID M A , HARRIS E , et al . Mosquito biting modulates skin response to virus infection [J ] . Trends in Parasitology , 2017 , 33 ( 8 ): 645 - 657 .

URAKI R , HASTINGS A K , MARIN-LOPEZ A , et al . Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice [J ] . Nature Microbiology , 2019 , 4 ( 6 ): 948 - 955 .

URAKI R , HASTINGS A K , BRACKNEY D E , et al . AgBR1 antibodies delay lethal Aedes aegypti -borne West Nile virus infection in mice [J ] . Npj Vaccines , 2019 , 4 : 23 .

SURASOMBATPATTANA P , EKCHARIYAWAT P , HAMEL R , et al . Aedes aegypti saliva contains a prominent 34 kDa protein that strongly enhances dengue virus replication in human keratinocytes [J ] . The Journal of Investigative Dermatology , 2014 , 134 ( 1 ): 281 - 284 .

MCCRACKEN M K , CHRISTOFFERSON R C , CHISENHALL D M , et al . Analysis of early dengue virus infection in mice as modulated by Aedes aegypti probing [J ] . Journal of Virology , 2014 , 88 ( 4 ): 1881 - 1889 .

JIN L , GUO X M , SHEN C B , et al . Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor [J ] . Nature Immunology , 2018 , 19 ( 4 ): 342 - 353 .

CONWAY M J , WATSON A M , COLPITTS T M , et al . Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host [J ] . Journal of Virology , 2014 , 88 ( 1 ): 164 - 175 .

SCHMID M A , GLASNER D R , SHAH S , et al . Mosquito saliva increases endothelial permeability in the skin, immune cell migration, and dengue pathogenesis during antibody-dependent enhancement [J ] . PLoS Pathogens , 2016 , 12 ( 6 ): e1005676 .

MOYA A , HOLMES E C , GONZÁLEZ-CANDELAS F . The population genetics and evolutionary epidemiology of RNA viruses [J ] . Nature Reviews Microbiology , 2004 , 2 ( 4 ): 279 - 288 .

DOLAN P T , WHITFIELD Z J , ANDINO R . Mechanisms and concepts in RNA virus population dynamics and evolution [J ] . Annual Review of Virology , 2018 , 5 ( 1 ): 69 - 92 .

MUSTAFA M S , RASOTGI V , JAIN S , et al . Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control [J ] . Medical Journal Armed Forces India , 2015 , 71 ( 1 ): 67 - 70 .

DÍAZ F J , BLACK W C IV , FARFÁN-ALE J A , et al . Dengue virus circulation and evolution in Mexico: a phylogenetic perspective [J ] . Archives of Medical Research , 2006 , 37 ( 6 ): 760 - 773 .

ZHANG C L , Jr MAMMEN M P , CHINNAWIROTPISAN P , et al . Clade replacements in dengue virus serotypes 1 and 3 are associated with changing serotype prevalence [J ] . Journal of Virology , 2005 , 79 ( 24 ): 15123 - 15130 .

LEWIS J A , CHANG G J , LANCIOTTI R S , et al . Phylogenetic relationships of dengue-2 viruses [J ] . Virology , 1993 , 197 ( 1 ): 216 - 224 .

RICO-HESSE R , HARRISON L M , NISALAK A , et al . Molecular evolution of dengue type 2 virus in Thailand [J ] . The American Journal of Tropical Medicine and Hygiene , 1998 , 58 ( 1 ): 96 - 101 .

MESSER W B , GUBLER D J , HARRIS E , et al . Emergence and global spread of a dengue serotype 3, subtype Ⅲvirus [J ] . Emerging Infectious Diseases , 2003 , 9 ( 7 ): 800 - 809 .

LANCIOTTI R S , LEWIS J G , GUBLER D J , et al . Molecular evolution and epidemiology of dengue-3 viruses [J ] . The Journal of General Virology , 1994 , 75 ( Pt 1 ): 65 - 75 .

WANG E , NI H , XU R , et al . Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses [J ] . Journal of Virology , 2000 , 74 ( 7 ): 3227 - 3234 .

LANCIOTTI R S , GUBLER D J , TRENT D W . Molecular evolution and phylogeny of dengue-4 viruses [J ] . The Journal of General Virology , 1997 , 78 ( Pt 9 ): 2279 - 2284 .

BALMASEDA A , HAMMOND S N , PÉREZ L , et al . Serotype-specific differences in clinical manifestations of dengue [J ] . The American Journal of Tropical Medicine and Hygiene , 2006 , 74 ( 3 ): 449 - 456 .

BURKE D S , NISALAK A , JOHNSON D E , et al . A prospective study of dengue infections in Bangkok [J ] . The American Journal of Tropical Medicine and Hygiene , 1988 , 38 ( 1 ): 172 - 180 .

GUZMÁN M G , KOURÍ G , VALDÉS L , et al . Enhanced severity of secondary dengue-2 infections: death rates in 1981 and 1997 Cuban outbreaks [J ] . Revista Panamericana De Salud Publica=Pan American Journal of Public Health , 2002 , 11 ( 4 ): 223 - 227 .

NISALAK A , ENDY T P , NIMMANNITYA S , et al . Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999 [J ] . The American Journal of Tropical Medicine and Hygiene , 2003 , 68 ( 2 ): 191 - 202 .

SANGKAWIBHA N , ROJANASUPHOT S , AHANDRIK S , et al . Risk factors in dengue shock syndrome: a prospective epidemiologic study in rayong, Thailand:Ⅰ. the 1980 outbreak [J ] . American Journal of Epidemiology , 1984 , 120 ( 5 ): 653 - 669 .

THEIN S , AUNG M M , SHWE T N , et al . Risk factors in dengue shock syndrome [J ] . The American Journal of Tropical Medicine and Hygiene , 1997 , 56 ( 5 ): 566 - 572 .

GRAHAM R R , JUFFRIE M , TAN R , et al . A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, IndonesiaⅠ. studies in 1995—1996 [J ] . The American Journal of Tropical Medicine and Hygiene , 1999 , 61 ( 3 ): 412 - 419 .

HARRIS E , VIDEA E , PÉREZ L , et al . Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua [J ] . The American Journal of Tropical Medicine and Hygiene , 2000 , 63 ( 1/2 ): 5 - 11 .

MESSER W B , VITARANA U T , SIVANANTHAN K , et al . Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever [J ] . The American Journal of Tropical Medicine and Hygiene , 2002 , 66 ( 6 ): 765 - 773 .

LEITMEYER K C , VAUGHN D W , WATTS D M , et al . Dengue virus structural differences that correlate with pathogenesis [J ] . Journal of Virology , 1999 , 73 ( 6 ): 4738 - 4747 .

COLOGNA R , RICO-HESSE R . American genotype structures decrease dengue virus output from human monocytes and dendritic cells [J ] . Journal of Virology , 2003 , 77 ( 7 ): 3929 - 3938 .

PRYOR M J , CARR J M , HOCKING H , et al . Replication of dengue virus type 2 in human monocyte-derived macrophages: comparisons of isolates and recombinant viruses with substitutions at amino acid 390 in the envelope glycoprotein [J ] . The American Journal of Tropical Medicine and Hygiene , 2001 , 65 ( 5 ): 427 - 434 .

OHAINLE M , BALMASEDA A , MACALALAD A R , et al . Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity [J ] . Science Translational Medicine , 2011 , 3 ( 114 ): 114 - 128 .

CHEN H L , LIN S R , LIU H F , et al . Evolution of dengue virus type 2 during two consecutive outbreaks with an increase in severity in southern Taiwan in 2001—2002 [J ] . The American Journal of Tropical Medicine and Hygiene , 2008 , 79 ( 4 ): 495 - 505 .

MUSSO D , GUBLER D J . Zika virus [J ] . Clinical Microbiology Reviews , 2016 , 29 ( 3 ): 487 - 524 .

ENFISSI A , CODRINGTON J , ROOSBLAD J , et al . Zika virus genome from the americas [J ] . Lancet , 2016 , 387 ( 10015 ): 227 - 228 .

WINKLER G , RANDOLPH V B , CLEAVES G R , et al . Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer [J ] . Virology , 1988 , 162 ( 1 ): 187 - 196 .

ALCON S , TALARMIN A , DEBRUYNE M , et al . Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections [J ] . Journal of Clinical Microbiology , 2002 , 40 ( 2 ): 376 - 381 .

GUO M J , HUI L X , NIE Y W , et al . ZIKV viral proteins and their roles in virus-host interactions [J ] . Science China Life Sciences , 2021 , 64 ( 5 ): 709 - 719 .

YU X , SHAN C , ZHU Y B , et al . A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2021 , 118 ( 42 ): e2113015118 .

ZHU Z , CHAN J F W , TEE K M , et al . Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic [J ] . Emerging Microbes & Infections , 2016 , 5 ( 1 ): 1 - 12 .

YUAN L , HUANG X Y , LIU Z Y , et al . A single mutation in the prM protein of Zika virus contributes to fetal microcephaly [J ] . Science , 2017 , 358 ( 6365 ): 933 - 936 .

SHAN C , XIA H J , HALLER S L , et al . A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2020 , 117 ( 33 ): 20190 - 20197 .

GEERLING E , STEFFEN T L , BRIEN J D , et al . Current flavivirus research important for vaccine development [J ] . Vaccines , 2020 , 8 ( 3 ): 477 .

THEILER M , SMITH H H . The use of yellow fever virus modified by in vitro cultivation for human immunization [J ] . The Journal of Experimental Medicine , 1937 , 65 ( 6 ): 787 - 800 .

BOIGARD H , ALIMOVA A , MARTIN G R , et al . Zika virus-like particle (VLP) based vaccine [J ] . PLoS Neglected Tropical Diseases , 2017 , 11 ( 5 ): e0005608 .

URAKAMI A , NGWE TUN M M , MOI M L , et al . An envelope-modified tetravalent dengue virus-like-particle vaccine has implications for flavivirus vaccine design [J ] . Journal of Virology , 2017 , 91 ( 23 ): e01181 - e01117 .

RICHNER J M , HIMANSU S , DOWD K A , et al . Modified mRNA vaccines protect against Zika virus infection [J ] . Cell , 2017 , 168 ( 6 ): 1114 - 1125.e10 .

COLLINS N D , BARRETT A D T . Live attenuated yellow fever 17D vaccine: a legacy vaccine still controlling outbreaks in modern day [J ] . Current Infectious Disease Reports , 2017 , 19 ( 3 ): 14 .

SATCHIDANANDAM V . Japanese encephalitis vaccines [J ] . Current Treatment Options in Infectious Diseases , 2020 , 12 ( 4 ): 375 - 386 .

GUY B , BARRERE B , MALINOWSKI C , et al . From research to phaseⅢ: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine [J ] . Vaccine , 2011 , 29 ( 42 ): 7229 - 7241 .

THOMAS R E . Yellow fever vaccine-associated viscerotropic disease: current perspectives [J ] . Drug Design, Development and Therapy , 2016 , 10 : 3345 - 3353 .

DEM MARTINS R , PAVÃO A L B , DE OLIVEIRA P M N , et al . Adverse events following yellow fever immunization: report and analysis of 67 neurological cases in Brazil [J ] . Vaccine , 2014 , 32 ( 49 ): 6676 - 6682 .

BREUGELMANS J G , LEWIS R F , AGBENU E , et al . Adverse events following yellow fever preventive vaccination campaigns in eight African countries from 2007 to 2010 [J ] . Vaccine , 2013 , 31 ( 14 ): 1819 - 1829 .

MCMAHON A W , EIDEX R B , MARFIN A A , et al . Neurologic disease associated with 17D-204 yellow fever vaccination: a report of 15 cases [J ] . Vaccine , 2007 , 25 ( 10 ): 1727 - 1734 .

BURCHARD G D , CAUMES E , CONNOR B A , et al . Expert opinion on vaccination of travelers against Japanese encephalitis [J ] . Journal of Travel Medicine , 2009 , 16 ( 3 ): 204 - 216 .

HADINEGORO S R , ARREDONDO-GARCÍA J L , CAPEDING M R , et al . Efficacy and long-term safety of a dengue vaccine in regions of endemic disease [J ] . The New England Journal of Medicine , 2015 , 373 ( 13 ): 1195 - 1206 .

SRIDHAR S , LUEDTKE A , LANGEVIN E , et al . Effect of dengue serostatus on dengue vaccine safety and efficacy [J ] . The New England Journal of Medicine , 2018 , 379 ( 4 ): 327 - 340 .

GEORGE J , VALIANT W G , MATTAPALLIL M J , et al . Prior exposure to Zika virus significantly enhances peak dengue-2 viremia in rhesus macaques [J ] . Scientific Reports , 2017 , 7 : 10498 .

DEJNIRATTISAI W , SUPASA P , WONGWIWAT W , et al . Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with Zika virus [J ] . Nature Immunology , 2016 , 17 ( 9 ): 1102 - 1108 .

BARDINA S V , BUNDUC P , TRIPATHI S , et al . Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity [J ] . Science , 2017 , 356 ( 6334 ): 175 - 180 .

FOWLER A M , TANG W W , YOUNG M P , et al . Maternally acquired Zika antibodies enhance dengue disease severity in mice [J ] . Cell Host & Microbe , 2018 , 24 ( 5 ): 743 - 750 .

KATZELNICK L C , GRESH L , HALLORAN M E , et al . Antibody-dependent enhancement of severe dengue disease in humans [J ] . Science , 2017 , 358 ( 6365 ): 929 - 932 .

KATZELNICK L C , NARVAEZ C , ARGUELLO S , et al . Zika virus infection enhances future risk of severe dengue disease [J ] . Science , 2020 , 369 ( 6507 ): 1123 - 1128 .

RAVIPRAKASH K , PORTER K R , KOCHEL T J , et al . Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques [J ] . The Journal of General Virology , 2000 , 81 ( Pt 7 ): 1659 - 1667 .

KHETARPAL N , KHANNA I . Dengue fever: causes, complications, and vaccine strategies [J ] . Journal of Immunology Research , 2016 , 2016 : 6803098 .

WONG G , GAO G F . An mRNA-based vaccine strategy against Zika [J ] . Cell Research , 2017 , 27 ( 9 ): 1077 - 1078 .

JIMÉNEZ DE OYA N , ESCRIBANO-ROMERO E , BLÁZQUEZ A B , et al . Current progress of avian vaccines against west Nile virus [J ] . Vaccines , 2019 , 7 ( 4 ): 126 .

KHOU C , PARDIGON N . Identifying attenuating mutations: tools for a new vaccine design against flaviviruses [J ] . Intervirology , 2017 , 60 ( 1/2 ): 8 - 18 .

LONDONO-RENTERIA B , TROUPIN A , COLPITTS T M . Arbovirosis and potential transmission blocking vaccines [J ] . Parasites & Vectors , 2016 , 9 ( 1 ): 516 .

WU S F , LEE C J , LIAO C L , et al . Antiviral effects of an iminosugar derivative on flavivirus infections [J ] . Journal of Virology , 2002 , 76 ( 8 ): 3596 - 3604 .

TCHANKOUO-NGUETCHEU S , KHUN H , PINCET L , et al . Differential protein modulation in midguts of Aedes aegypti infected with chikungunya and dengue 2 viruses [J ] . PLoS One , 2010 , 5 ( 10 ): e13149 .

THAM H W , BALASUBRAMANIAM V R M T , TEJO B A , et al . CPB 1 of Aedes aegypti interacts with DENV2 E protein and regulates intracellular viral accumulation and release from midgut cells [J ] . Viruses , 2014 , 6 ( 12 ): 5028 - 5046 .

DINGLASAN R R , VALENZUELA J G , AZAD A F . Sugar epitopes as potential universal disease transmission blocking targets [J ] . Insect Biochemistry and Molecular Biology , 2005 , 35 ( 1 ): 1 - 10 .

LIU K , QIAN Y J , JUNG Y S , et al . mosGCTL-7, a C-type lectin protein, mediates Japanese encephalitis virus infection in mosquitoes [J ] . Journal of Virology , 2017 , 91 ( 10 ): e01348 - e01316 .

PERERA-LECOIN M , MEERTENS L , CARNEC X , et al . Flavivirus entry receptors: an update [J ] . Viruses , 2014 , 6 ( 1 ): 69 - 88 .

PERERA R , KHALIQ M , KUHN R J . Closing the door on flaviviruses: entry as a target for antiviral drug design [J ] . Antiviral Research , 2008 , 80 ( 1 ): 11 - 22 .

LI P C , JANG J , HSIA C Y , et al . Small molecules targeting the flavivirus E protein with broad-spectrum activity and antiviral efficacy in vivo [J ] . ACS Infectious Diseases , 2019 , 5 ( 3 ): 460 - 472 .

KAMPMANN T , YENNAMALLI R , CAMPBELL P , et al . In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses [J ] . Antiviral Research , 2009 , 84 ( 3 ): 234 - 241 .

ZHANG W , CHIPMAN P R , CORVER J , et al . Visualization of membrane protein domains by cryo-electron microscopy of dengue virus [J ] . Nature Structural & Molecular Biology , 2003 , 10 ( 11 ): 907 - 912 .

COSTIN J M , JENWITHEESUK E , LOK S M , et al . Structural optimization and de novo design of dengue virus entry inhibitory peptides [J ] . PLoS Neglected Tropical Diseases , 2010 , 4 ( 6 ): e721 .

ALTMEYER R . Virus attachment and entry offer numerous targets for antiviral therapy [J ] . Current Pharmaceutical Design , 2004 , 10 ( 30 ): 3701 - 3712 .

DIGHE S N , EKWUDU O , DUA K , et al . Recent update on anti-dengue drug discovery [J ] . European Journal of Medicinal Chemistry , 2019 , 176 : 431 - 455 .

KANG C B , KELLER T H , LUO D H . Zika virus protease: an antiviral drug target [J ] . Trends in Microbiology , 2017 , 25 ( 10 ): 797 - 808 .

NITSCHE C . Proteases from dengue, West Nile and Zika viruses as drug targets [J ] . Biophysical Reviews , 2019 , 11 ( 2 ): 157 - 165 .

KOK W M . New developments in flavivirus drug discovery [J ] . Expert Opinion on Drug Discovery , 2016 , 11 ( 5 ): 433 - 445 .

RAY D , SHI P Y . Recent advances in flavivirus antiviral drug discovery and vaccine development [J ] . Recent Patents on Anti-Infective Drug Discovery , 2006 , 1 ( 1 ): 45 - 55 .

MASTRANGELO E , PEZZULLO M , DE BURGHGRAEVE T , et al . Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug [J ] . Journal of Antimicrobial Chemotherapy , 2012 , 67 ( 8 ): 1884 - 1894 .

BOLLATI M , ALVAREZ K , ASSENBERG R , et al . Structure and functionality in flavivirus NS-proteins: perspectives for drug design [J ] . Antiviral Research , 2010 , 87 ( 2 ): 125 - 148 .

CHATRIN C , TALAPATRA S K , CANARD B , et al . The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping [J ] . Oncotarget , 2018 , 9 ( 3 ): 3160 - 3171 .

ZHOU Y S , RAY D , ZHAO Y W , et al . Structure and function of flavivirus NS5 methyltransferase [J ] . Journal of Virology , 2007 , 81 ( 8 ): 3891 - 3903 .

AFAQ S , ATIYA A , MALIK A , et al . Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV) [J ] . Bioinformation , 2020 , 16 ( 3 ): 229 - 235 .

BRECHER M , CHEN H , LI Z , et al . Identification and characterization of novel broad-spectrum inhibitors of the flavivirus methyltransferase [J ] . ACS Infectious Diseases , 2015 , 1 ( 8 ): 340 - 349 .

NOBLE C G , LI S H , DONG H P , et al . Crystal structure of dengue virus methyltransferase without S -adenosyl-L-methionine [J ] . Antiviral Research , 2014 , 111 : 78 - 81 .

WANG B X , THURMOND S , HAI R , et al . Structure and function of Zika virus NS5 protein: perspectives for drug design [J ] . Cellular and Molecular Life Sciences , 2018 , 75 ( 10 ): 1723 - 1736 .

JAIN R , BUTLER K V , COLOMA J , et al . Development of a S -adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase [J ] . Scientific Reports , 2017 , 7 : 1632 .

LIM S V , RAHMAN M B A , TEJO B A . Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus [J ] . BMC Bioinformatics , 2011 , 12 ( Suppl 13 ): S24 .

BRECHER M , CHEN H , LIU B B , et al . Novel broad spectrum inhibitors targeting the flavivirus methyltransferase [J ] . PLoS One , 2015 , 10 ( 6 ): e0130062 .

SIQUEIRA-BATISTA R , DE SOUZA BAYÃO T , DO CARMO CUPERTINO M , et al . Sofosbuvir use for yellow fever: a new perspective treatment [J ] . Pathogens and Global Health , 2019 , 113 ( 5 ): 207 - 208 .

BULLARD-FEIBELMAN K M , GOVERO J , ZHU Z , et al . The FDA-approved drug sofosbuvir inhibits Zika virus infection [J ] . Antiviral Research , 2017 , 137 : 134 - 140 .

FERREIRA A C , ZAVERUCHA-DO-VALLE C , REIS P A , et al . Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae [J ] . Scientific Reports , 2017 , 7 : 9409 .

JACOBS S , DELANG L E , VERBEKEN E , et al . A viral polymerase inhibitor reduces Zika virus replication in the reproductive organs of male mice [J ] . International Journal of Molecular Sciences , 2019 , 20 ( 9 ): 2122 .

IVANOVA T , HARDES K , KALLIS S , et al . Optimization of substrate-analogue furin inhibitors [J ] . ChemMedChem , 2017 , 12 ( 23 ): 1953 - 1968 .

SKRZYPEK R , CALLAGHAN R . The "pushmi-pullyu" of resistance to chloroquine in malaria [J ] . Essays in Biochemistry , 2017 , 61 ( 1 ): 167 - 175 .

BYRD C M , DAI D C , GROSENBACH D W , et al . A novel inhibitor of dengue virus replication that targets the capsid protein [J ] . Antimicrobial Agents and Chemotherapy , 2013 , 57 ( 1 ): 15 - 25 .

QIN C F , QIN E D . Capsid-targeted viral inactivation can destroy dengue 2 virus from within in vitro [J ] . Archives of Virology , 2006 , 151 ( 2 ): 379 - 385 .

STOERMER K A , MORRISON T E . Complement and viral pathogenesis [J ] . Virology , 2011 , 411 ( 2 ): 362 - 373 .

AKEY D L , BROWN W C , JOSE J , et al . Structure-guided insights on the role of NS1 in flavivirus infection [J ] . BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology , 2015 , 37 ( 5 ): 489 - 494 .

SOMNUKE P , HAUHART R E , ATKINSON J P , et al . N -linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement [J ] . Virology , 2011 , 413 ( 2 ): 253 - 264 .

WATTERSON D , MODHIRAN N , YOUNG P R . The many faces of the flavivirus NS1 protein offer a multitude of options for inhibitor design [J ] . Antiviral Research , 2016 , 130 : 7 - 18 .