ÖZKARA A , AKYIL D , KONUK M . Pesticides, environmental pollution, and health [M ] //LARRAMENDY ML, SOLONESKI S. Enviromental health risk—Hazardous factors to living species . In Tech, 2016 : 1 - 26 .

NICOLOPOULOU-STAMATI P , MAIPAS S , KOTAMPASI C , et al . Chemical pesticides and human health: the urgent need for a new concept in agriculture [J ] . Frontiers in Public Health , 2016 , 4 : 148 .

CARVALHO P F . Pesticides, environment, and food safety [J ] . Food & Energy Security , 2017 , 6 ( 2 ): 48 - 60 .

COSTA J A V , FREITAS B C B , CRUZ C G , et al . Potential of microalgae as biopesticides to contribute to sustainable agriculture and environmental development [J ] . Journal of Environmental Science and Health Part B Pesticides, Food Contaminants, and Agricultural Wastes , 2019 , 54 ( 5 ): 366 - 375 .

SCHUSTER C , KONSTANTINIDOU-DOLTSINIS S , SCHMITT A . Glycyrrhiza glabra extract protects plants against important phytopathogenic fungi [J ] . Communications in Agricultural and Applied Biological Sciences , 2010 , 75 ( 4 ): 531 - 540 .

BARDIN M , AJOUZ S , COMBY M , et al . Is the efficacy of biological control against plant diseases likely to be more durable than that of chemical pesticides [J ] ? Frontiers in Plant Science , 2015 , 6 : 566 .

LAHLOU M . Methods to study the phytochemistry and bioactivity of essential oils [J ] . Phytotherapy Research , 2004 , 18 ( 6 ): 435 - 448 .

CASIDA J E , QUISTAD G B . Pyrethrum flowers: production, chemistry, toxicology, and uses [M ] . Oxford University Press , 1995 : 1 - 25 .

ISMAN M B . Botanical insecticides in the twenty-first century-fulfilling their promise [J ] ? Annual Review of Entomology , 2020 , 65 : 233 - 249 .

LYBRAND D B , XU H , LAST R L , et al . How plants synthesize pyrethrins: safe and biodegradable insecticides [J ] . Trends in Plant Science , 2020 , 25 ( 12 ): 1240 - 1251 .

XU H Y , MOGHE G D , WIEGERT-RININGER K , et al . Coexpression analysis identifies two oxidoreductases involved in the biosynthesis of the monoterpene acid moiety of natural pyrethrin insecticides in Tanacetum cinerariifolium [J ] . Plant Physiology , 2018 , 176 ( 1 ): 524 - 537 .

LI W , LYBRAND D B , ZHOU F , et al . Pyrethrin biosynthesis: the cytochrome P450 oxidoreductase CYP82Q3 converts jasmolone to pyrethrolone [J ] . Plant Physiology , 2019 , 181 ( 3 ): 934 - 944 .

LI W , ZHOU F , PICHERSKY E . Jasmone hydroxylase, a key enzyme in the synthesis of the alcohol moiety of pyrethrin insecticides [J ] . Plant Physiology , 2018 , 177 ( 4 ): 1498 - 1509 .

BAN D , BARBARA S , MARINA L , et al . Comparison of pyrethrins eextraction methods efficiencies [J ] . African Journal of Biotechnology , 2010 , 9 ( 18 ), 2702 - 2708 .

XU H , LI W , SCHILMILLER A L , et al . Pyrethric acid of natural pyrethrin insecticide: complete pathway elucidation and reconstitution in Nicotiana benthamiana [J ] . The New Phytologist , 2019 , 223 ( 2 ): 751 - 765 .

XU H , LYBRAND D , BENNEWITZ S , et al . Production of trans -chrysanthemic acid, the monoterpene acid moiety of natural pyrethrin insecticides, in tomato fruit [J ] . Metabolic Engineering , 2018 , 47 : 271 - 278 .

HU H , LI J , DELATTE T , et al . Modification of chrysanthemum odour and taste with chrysanthemol synthase induces strong dual resistance against cotton aphids [J ] . Plant Biotechnology Journal , 2018 , 16 ( 8 ): 1434 - 1445 .

CLARK J F . Bugs in the system: insects, agricultural science, and professional aspirations in Britain, 1890-1920 [J ] . Agricultural History , 2001 , 75 ( 1 ): 83 - 114 .

GRUNGE W H . Japan ' s pyrethrum position threatened [J ] . Far Eastern Survey , 1939 , 8 ( 9 ): 109 - 110 .

JERAN N , GRDIŠA M , VARGA F , et al . Pyrethrin from Dalmatian pyrethrum ( Tanacetum cinerariifolium /Trevir./Sch. Bip.): Biosynthesis, biological activity, methods of extraction and determination [J ] . Phytochemistry Reviews , 2020 . doi: 10.1007/s/1101-020-09724-2 http://dx.doi.org/10.1007/s/1101-020-09724-2 .

YANG T , STOOPEN G , WIEGERS G , et al . Pyrethrins protect pyrethrum leaves against attack by western flower thrips, Frankliniella occidentalis [J ] . Journal of Chemical Ecology , 2012 , 38 ( 4 ): 370 - 377 .

RAMIREZ A M , STOOPEN G , MENZEL T R , et al . Bidirectional secretions from glandular trichomes of pyrethrum enable immunization of seedlings [J ] . The Plant Cell , 2012 , 24 ( 10 ): 4252 - 4265 .

BLOOMQUIST J R . Chloride channels as tools for developing selective insecticides [J ] . Archives of Insect Biochemistry and Physiology , 2003 , 54 ( 4 ): 145 - 156 .

DAVIES T G , FIELD L M , USHERWOOD P N , et al . DDT, pyrethrins, pyrethroids and insect sodium channels [J ] . IUBMB Life , 2007 , 59 ( 3 ): 151 - 162 .

CASIDA J E . Pyrethrum, the natural insecticide [M ] . Pittsburgh : Academic Press , 1973 : 101 - 120 .

ISMAN M B . Botanical insecticides: for richer, for poorer [J ] . Pest Management Science , 2008 , 64 ( 1 ): 8 - 11 .

KALINOVIĆ I , KORUNIĆ Z , ROZMAN V , et al . Effectiveness of pure diatomaceous earth and different mixtures of diatomaceous earth with pyrethrins [J ] . Poljoprivreda , 2011 , 17 ( 2 ): 13 - 17 .

AKHTAR Y , YEOUNG Y R , ISMAN M B . Comparative bioactivity of selected extracts from Meliaceae and some commercial botanical insecticides against two noctuid caterpillars, Trichoplusia ni and Pseudaletia unipuncta [J ] . Phytochemistry Reviews , 2008 , 7 ( 1 ): 77 - 88 .

JOFFE T , GUNNING R V , ALLEN G R , et al . Investigating the potential of selected natural compounds to increase the potency of pyrethrum against houseflies Musca domestica (Diptera: Muscidae) [J ] . Pest Management Science , 2012 , 68 ( 2 ): 178 - 184 .

KALAITZAKI A , PAPANIKOLAOU N E , KARAMAOUNA F , et al . Biocompatible colloidal dispersions as potential formulations of natural pyrethrins: a structural and efficacy study [J ] . Langmuir , 2015 , 31 ( 21 ): 5722 - 5730 .

PAL R . Use of pyrethrum in vector control [J ] . Bulletin of the World Health Organisation , 1960 , 22 : 595 - 599 .

PAJNIK J , STAMENIĆ M , RADETIĆ M , et al . Impregnation of cotton fabric with pyrethrum extract in supercritical carbon dioxide [J ] . Journal of Supercritical Fluids , 2017 , 128 : 66 - 72 .

BOYCE W M , LAWLER S P , SCHULTZ J M , et al . Nontarget effects of the mosquito adulticide pyrethrin applied aerially during a West Nile virus outbreak in an urban California environment [J ] . Journal of the American Mosquito Control Association , 2007 , 23 ( 3 ): 335 - 339 .

SCHLEIER Ⅲ J J , PETERSON R K D . Pyrethrins and pyrethroid insecticides [M ] //LOPEZ O, FerNANDER-BOLANOS J. Green trends in insect control . The Royal Society of Chemistry, 2011 : 94 - 131 .

FENG X X , PAN L X , WANG C , et al . Residue analysis and risk assessment of pyrethrins in open field and greenhouse turnips [J ] . Environmental Science and Pollution Research , 2018 , 25 ( 1 ): 877 - 886 .

PAN L X , FENG X X , ZHANG H Y . Dissipation and residues of pyrethrins in leaf lettuce under greenhouse and open field conditions [J ] . International Journal of Environmental Research and Public Health , 2017 , 14 ( 7 ): 822 .

ANTONIOUS G F , BYERS M E , KERST W C . Residue levels of pyrethrins and piperonyl butoxide in soil and runoff water [J ] . Journal of Environmental Science and Health, Part B , 1997 , 32 ( 5 ): 621 - 644 .

ANTONIOUS G F . Residues and half-lives of pyrethrins on field-grown pepper and tomato [J ] . Journal of Environmental Science and Health, Part B , 2004 , 39 ( 4 ): 491 - 503 .

ANGIONI A , DEDOLA F , MINELLI E V , et al . Residues and half-life times of pyrethrins on peaches after field treatments [J ] . Journal of Agricultural and Food Chemistry , 2005 , 53 ( 10 ): 4059 - 4063 .

CHENG X , UMINA P A , LEE S F , et al . Pyrethroid resistance in the pest mite, Halotydeus destructor : dominance patterns and a new method for resistance screening [J ] . Pesticide Biochemistry and Physiology , 2019 , 159 : 9 - 16 .

MAESTRE‐SERRANO R , PAREJA‐LOAIZA P , GOMEZ C D , et al . Co‐occurrence of V1016I and F1534C mutations in the voltage‐gated sodium channel and resistance to pyrethroids in Aedes aegypti (L.) from the Colombian Caribbean region [J ] . Pest Management Science , 2019 , 75 ( 6 ): 1681 - 1688 .

LI H , CHENG F , WEI Y , et al . Global occurrence of pyrethroid insecticides in sediment and the associated toxicological effects on benthic invertebrates: an overview [J ] . Journal of Hazardous Materials , 2017 , 324 : 258 - 271 .

STEHLE S , SCHULZ R . Agricultural insecticides threaten surface waters at the global scale [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2015 , 112 ( 18 ): 5750 - 5755 .

KGOROEBUTSWE T K , RAMATLHO P , REEDER S , et al . Distribution of Anopheles mosquito species, their vectorial role and profiling of knock-down resistance mutations in Botswana [J ] . Parasitology Research , 2020 , 119 ( 4 ): 1201 - 1208 .

MATSUO N . Discovery and development of pyrethroid insecticides [J ] . Proceedings of the Japan Academy Series B, Physical and Biological Sciences , 2019 , 95 ( 7 ): 378 - 400 .

STAUDINGER H , RUZICKA L , INSEKTENTÖTENDE STOFFE Ⅰ . Über Isolierung und Konstitution des wirksamen Teiles des dalmatinischen Insektenpulvers [J ] . Helvetica Chimica Acta , 1924 , 7 ( 1 ): 177 - 201 .

LAFORGE F B , BARTHEL W F . Constituents of pyrethrum flowers; the partial synthesis of pyrethrins and cinerins and their relative toxicities [J ] . The Journal of Organic Chemistry , 1947 , 12 ( 1 ): 199 - 202 .

INOUYE Y , TAKESHIYA Y , OHNO M . Studies on synthetic pyrethroids. Part V. synthesis of geometrical isomers of chrysanthemum dicarboxylic acid [J ] . Scientific Pest Control , 2008 , 19 ( 3 ): 193 - 199 .

KATSUDA Y , CHIKAMOTO T , INOUYE Y . The absolute configuration of naturally derived pyrethrolone and cinerolone [J ] . Bulletin of the Agricultural Chemical Society of Japan , 1958 , 22 ( 6 ): 427 - 428 .

GODIN P J , SLEEMAN R J , SNAREY M , et al . The jasmolins, new insecticidally active constituents of Chrysanthemum cinerariaefolium VIS [J ] . Journal of the Chemical Society C: Organic , 1966 ( 0 ): 332 - 334 .

KIKUTA Y , UEDA H , TAKAHASHI M , et al . Identification and characterization of a GDSL lipase-like protein that catalyzes the ester-forming reaction for pyrethrin biosynthesis in Tanacetum cinerariifolium -a new target for plant protection [J ] . Plant Journal , 2012 , 71 ( 2 ): 183 - 193 .

KAWAMOTO M , MORIYAMA M , ASHIDA Y , et al . Total syntheses of all six chiral natural pyrethrins: Accurate determination of the physical properties, their insecticidal activities, and evaluation of synthetic methods [J ] . The Journal of Organic Chemistry , 2020 , 85 ( 5 ): 2984 - 2999 .

KATSUDA Y . Progress and future of pyrethroids [J ] . Topics in Current Chemistry , 2011 , 314 : 1 - 30 .

DUCHON S , BONNET J , MARCOMBE S , et al . Pyrethrum: a mixture of natural pyrethrins has potential for malaria vector control [J ] . Journal of Medical Entomology , 2009 , 46 ( 3 ): 516 - 522 .

KAZUHIKO M . Pyrethrin biosynthesis and its regulation in Chrysanthemum cinerariaefolium [J ] . Topics in Current Chemistry , 2011 , 314 ( 1 ): 73 .

RIVERA S B , SWEDLUND B D , KING G J , et al . Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2001 , 98 ( 8 ): 4373 - 4378 .

LI W , LYBRAND D B , XU H , et al . A trichome-specific, plastid-localized Tanacetum cinerariifolium nudix protein hydrolyzes the natural pyrethrin pesticide biosynthetic intermediate trans -chrysanthemyl diphosphate [J ] . Frontiers in Plant Science , 2020 , 11 : 482 .

MATSUDA K , KIKUTA Y , HABA A , et al . Biosynthesis of pyrethrin I in seedlings of Chrysanthemum cinerariaefolium [J ] . Phytochemistry , 2005 , 66 ( 13 ): 1529 - 1535 .

SCHALLER A , STINTZI A . Enzymes in jasmonate biosynthesis—structure, function, regulation [J ] . Phytochemistry , 2009 , 70 ( 13/14 ): 1532 - 1538 .

MATSUI R , AMANO N , TAKAHASHI K , et al . Elucidation of the biosynthetic pathway of cis -jasmone in Lasiodiplodia theobromae [J ] . Scientific Reports , 2017 , 7 ( 1 ): 6688 .

UEDA H , KIKUTA Y , MATSUDA K . Plant communication: Mediated by individual or blended VOCs [J ] ? Plant Signaling & Behavior , 2012 , 7 ( 2 ): 222 - 226 .

ZDYB A , SALGADO M G , DEMCHENKO K N , et al . Allene oxide synthase, allene oxide cyclase and jasmonic acid levels in Lotus japonicus nodules [J ] . PLoS One , 2018 , 13 ( 1 ): e0190884 .

PENG Q , ZHOU Y , LIAO Y , et al . Functional characterization of an allene oxide synthase involved in biosynthesis of jasmonic acid and its influence on metabolite profiles and ethylene formation in tea ( Camellia sinensis ) flowers [J ] . International Journal of Molecular Sciences , 2018 , 19 ( 8 ): 2440 .

CHINI A , MONTE I , ZAMARREÑO A M , et al . An OPR3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis [J ] . Nature Chemical Biology , 2018 , 14 ( 2 ): 171 - 178 .

DABIRI M , MAJDI M , BAHRAMNEJAD B . Partial sequence isolation of DXS and AOS genes and gene expression analysis of terpenoids and pyrethrin biosynthetic pathway of Chrysanthemum cinerariaefolium under abiotic elicitation [J ] . Acta Physiologiae Plantarum , 2020 , 42 ( 3 ): 1 - 15 .

KIKUTA Y , UEDA H , NAKAYAMA K , et al . Specific regulation of pyrethrin biosynthesis in Chrysanthemum cinerariaefolium by a blend of volatiles emitted from artificially damaged conspecific plants [J ] . Plant and Cell Physiology , 2011 , 52 ( 3 ): 588 - 596 .

YAMASHIRO T , SHIRAISHI A , SATAKE H , et al . Draft genome of Tanacetum cinerariifolium , the natural source of mosquito coil [J ] . Scientific Reports , 2019 , 9 ( 1 ): 18249 .

PAN W H , CHANG C C , SU T T , et al . Preparative supercritical fluid extraction of pyrethrin I and II from pyrethrum flower [J ] . Talanta , 1995 , 42 ( 11 ): 1745 - 1749 .

KASAJ D , RIEDER A , KRENN L , et al . Separation and quantitative analysis of natural pyrethrins by high-performance liquid chromatography [J ] . Chromatographia , 1999 , 50 ( 9/10 ): 607 - 610 .

REVERCHON E , MARCO I D . Supercritical fluid extraction and fractionation of natural matter [J ] . Journal of Supercritical Fluids , 2006 , 38 ( 2 ): 146 - 166 .

NAZARI F , KAMBARANI M . Extraction and determination of pyrethrins from pyrethrum cultivated in Iran [J ] . Journal of Medicinal Plants . 2008 , 7 ( 25 ): 79 - 84,119 .

NAGAR A , CHATTERJEE A , U REHMAN L , et al . Comparative extraction and enrichment techniques for pyrethrins from flowers of Chrysanthemum cinerariaefolium [J ] . Industrial Crops and Products , 2015 , 76 : 955 - 960 .

KIRIAMITI H K , CAMY S , GOURDON C , et al . Pyrethrin exraction from pyrethrum flowers using carbon dioxide [J ] . Journal of Supercritical Fluids , 2003 , 26 ( 3 ): 193 - 200 .

BABIC S , GRDIA M , PERIA M , al . Ultrasound-assisted extraction of pyrethrins from pyrethrum flowers [J ] . Agrochimica-Pisa- , 2012 , 56 ( 4/5 ): 193 - 206 .

MARTÍN L , MARQUÉS J L , GONZÁLEZ-COLOMA A , et al . Supercritical methodologies applied to the production of biopesticides: a review [J ] . Phytochemistry Reviews , 2012 , 11 ( 4 ): 413 - 431 .

LEVY L W . A large-scale application of tissue culture: the mass propagation of pyrethrum clones in ecuador [J ] . Environmental and Experimental Botany , 1981 , 21 ( 3/4 ): 389 - 395 .

ZITO S W , TIO C D . Constituents of Chrysanthemum cinerariaefolium in leaves, regenerated plantlets and callus [J ] . Phytochemistry , 1990 , 29 ( 8 ): 2533 - 2534 .

HITMI A , COUDRET A , BARTHOMEUF C . The production of pyrethrins by plant cell and tissue cultures of Chrysanthemum cinerariaefolium and tagetes species [J ] . Critical Reviews in Plant Sciences , 2000 , 19 ( 1 ): 69 - 89 .

KHAN S A , VERMA P , PARASHARAMI V A , et al . In vitro manipulations for value addition in potent herbal insecticidal activities of Chrysanthemum cinerariaefolium [M ] //KUMAR N. Biotechnological approaches for medicinal and aromatic plants . Singapore : Springer , 2018 : 395 - 416 .

JEANMART S . Trends in chrysanthemic acid chemistry: a survey of recent pyrethrum syntheses [J ] . Australian Journal of Chemistry , 2003 , 56 ( 6 ): 559 - 566 .

BRAMWELL A F , CROMBIE L , HEMESLEY P , et al . Nuclear magnetic resonance spectra of the natural pyrethrins and related compounds [J ] . Tetrahedron , 1969 , 25 ( 8 ): 1727 - 1741 .

KUMAR M , SUN Y , RATHOUR R , et al . Algae as potential feedstock for the production of biofuels and value-added products: opportunities and challenges [J ] . The Science of the Total Environment , 2020 , 716 : 137116 .

GALANIE S , THODEY K , TRENCHARD I J , et al . Complete biosynthesis of opioids in yeast [J ] . Science , 2015 , 349 ( 6252 ): 1095 - 1100 .

闻志强 , 孙小曼 , 汪庆卓 等 . 梭菌正丁醇代谢工程研究进展 [J ] . 合成生物学 , 2021 , 2 ( 2 ): 194 - 221 .

WEN Z Q , SUN X M , WANG Q Z , et al . Recent advances in metabolic engineering of clostridia for n -butanol production [J ] . Synthetic Biology Journal , 2021 , 2 ( 2 ): 194 - 221 .

RO D K , PARADISE E M , OUELLET M , et al . Production of the antimalarial drug precursor artemisinic acid in engineered yeast [J ] . Nature , 2006 , 440 ( 7086 ): 940 - 943 .

MCCARTY N S , LEDESMA-AMARO R . Synthetic biology tools to engineer microbial communities for biotechnology [J ] . Trends in Biotechnology , 2019 , 37 ( 2 ): 181 - 197 .

ZHU Q , YU S , ZENG D , et al . Development of “purple endosperm rice” by engineering anthocyanin biosynthesis in the endosperm with a high-efficiency transgene stacking system [J ] . Molecular Plant , 2017 , 10 ( 7 ): 918 - 929 .

FU R , ZHANG P , JIN G , et al . Versatility in acyltransferase activity completes chicoric acid biosynthesis in purple coneflower [J ] . Nature Communications , 2021 , 12 ( 1 ): 1563 .