人工多细胞体系设计与构建研究进展

钱秀娟; 陈琳; 章文明; 周杰; 董维亮; 信丰学; 姜岷

doi:10.12211/2096-8280.2020-040

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人工多细胞体系设计与构建研究进展

特约评述 | 更新时间：2025-03-20

- 人工多细胞体系设计与构建研究进展
- Recent research progress in the design and construction of synthetic microbial consortia
- 合成生物学 2020年1卷第3期页码：267-284
- 作者机构：
  
  1.南京工业大学材料化学工程国家重点实验室，江苏南京 211816
  2.南京工业大学江苏先进生物与化学制造协同创新中心（SICAM），江苏南京 211816
- 作者简介：
  
  [ "钱秀娟（1992—），女，博士，博士后，研究方向为代谢工程及合成生物学。E-mail：xiujuanqian@njtech.edu.cn" ]
  [ "信丰学（1982—），男，博士，教授，研究方向为生物化工与生物能源。E-mail:xinfengxue@njtech.edu.cn" ]
  [ "姜岷（1972—），男，博士，教授，研究方向为生物转化与生物催化。E-mail:jiangmin@njtech.edu.cn" ]
- 基金信息：
  
  国家重点研发计划“合成生物学”重点专项(2018YFA0902200;2019YFA0905500);国家自然科学基金项目(31961133017;21978130;21978129)
- DOI：10.12211/2096-8280.2020-040
  中图分类号： Q812
- 收稿：2020-04-05，
  
  修回：2020-08-03，
  
  纸质出版：2020-06-30
- 稿件说明：
移动端阅览
钱秀娟, 陈琳, 章文明, 周杰, 董维亮, 信丰学, 姜岷. 人工多细胞体系设计与构建研究进展[J]. 合成生物学, 2020, 1(3): 267-284

QIAN Xiujuan, CHEN Lin, ZHANG Wenming, ZHOU Jie, DONG Weiliang, XIN Fengxue, JIANG Min. Recent research progress in the design and construction of synthetic microbial consortia[J]. Synthetic Biology Journal, 2020, 1(3): 267-284
钱秀娟, 陈琳, 章文明, 周杰, 董维亮, 信丰学, 姜岷. 人工多细胞体系设计与构建研究进展[J]. 合成生物学, 2020, 1(3): 267-284 DOI： 10.12211/2096-8280.2020-040.

QIAN Xiujuan, CHEN Lin, ZHANG Wenming, ZHOU Jie, DONG Weiliang, XIN Fengxue, JIANG Min. Recent research progress in the design and construction of synthetic microbial consortia[J]. Synthetic Biology Journal, 2020, 1(3): 267-284 DOI： 10.12211/2096-8280.2020-040.

摘要

合成生物学的发展正从优化基因元件与模块走向从头设计复杂代谢线路。多细胞体系因可实现代谢功能分工、复杂底物多组分利用及耐受复杂环境等，在医药、食品、化工、环境及能源等领域发挥着不可替代的作用，并已成为合成生物学发展的新方向。然而，多细胞体系的研究还处于起步阶段，理性设计与构建人工多细胞体系、解析细胞间信息互作机制及调控多细胞体系结构等方面还面临诸多挑战。本文综述了人工多细胞体系在医药开发与医疗健康、天然产物合成、木质纤维素一体化生物加工以及环境修复等领域的应用，总结了人工多细胞体系的构建原理，阐述了多细胞体系内细胞间的交流机制，并剖析了人工多细胞体系面临的诸多挑战以及针对性的解决方案，为构建系统鲁棒、稳定、可控的人工多细胞体系提供理论指导。

Abstract

Synthetic biology is developed from designing and building simple elements and modules to

de novo

buildup complex metabolic pathway and network. Recent advances in microbial consortia present a valuable approach for expanding the scope of synthetic biology. First

microbial consortia can create a novel microenvironment for strains

potentially resulting in the activation of silent metabolic pathways which are not expressed under "normal" cultivation conditions

leading to discovery of novel chemicals for novel drugs and other purposes; Second

microbial consortia allow a labor division for metabolic modules among different microbial strains

which permit improved efficiency and more complex behavior than monocultures; Third

microbial consortia consist of multiple functional microorganisms

allowing capability for utilizing complex substrate with robust tolerance to environmental stresses. All these endow microbial consortia an indispensible role in the areas of medicine

food

chemical engineering

energy industry and biodegradation for environmental pollutants. However

the study of synthetic microbial consortia is still in its infancy

facing many unknowns and challenges in the construction of stable and controllable microbial consortia systems

intercellular communication and regulation of microbial population structure. This review summarizes the application of synthetic mic

robial consortia in the areas of human health monitoring and medicine exploitation

synthesis of valuable compounds

consolidated bioprocessing of lignocellulosic materials and environmental bioremediation

as well as the construction principles and research methods for microbial consortia study. In addition

the unrevealed interaction mechanism underlying microbial consortia is addressed. Moreover

the outstanding challenges and future directions to advance the development of high-efficient

stable and controllable synthetic microbial consortia are highlighted.

关键词

Keywords

references

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