塑造低碳经济的第三代固碳生物炼制

史硕博; 孟琼宇; 乔玮博; 赵惠民

doi:10.12211/2096-8280.2020-015

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塑造低碳经济的第三代固碳生物炼制

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- 塑造低碳经济的第三代固碳生物炼制
- Establishing carbon dioxide-based third-generation biorefinery for a sustainable low-carbon economy
- 合成生物学 2020年1卷第1期页码：44-59
- 作者机构：
  
  1.北京化工大学北京软物质科学与工程高精尖创新中心，北京 100029
  2.北京化工大学秦皇岛环渤海生物产业研究院，河北秦皇岛066000
  3.美国伊利诺伊大学香槟分校化学与生物分子工程系，伊利诺伊州厄巴纳-香槟市 IL61801
- 作者简介：
  
  [ "史硕博（1981-），男，博士，教授，主要从事微生物代谢工程及合成生物学研究。E-mail：shishuobo@mail.buct.edu.cn" ]
  [ "赵惠民（1969-），男，博士，现为伊利诺伊大学香槟分校化学与生物分子工程系Steven L. Miller讲座教授，主要从事合成生物学研究。E-mail：zhao5@illinois.edu" ]
- 基金信息：
  
  国家自然科学基金(21878013);国家重点研发计划(2018YFA0901800;2018YFA0900100)
- DOI：10.12211/2096-8280.2020-015
  中图分类号： Q819
- 收稿：2020-03-02，
  
  修回：2020-04-14，
  
  纸质出版：2020-02-29
- 稿件说明：
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史硕博, 孟琼宇, 乔玮博, 赵惠民. 塑造低碳经济的第三代固碳生物炼制[J]. 合成生物学, 2020, 1(1): 44-59

SHI Shuobo, MENG Qiongyu, QIAO Weibo, ZHAO Huimin. Establishing carbon dioxide-based third-generation biorefinery for a sustainable low-carbon economy[J]. Synthetic Biology Journal, 2020, 1(1): 44-59
史硕博, 孟琼宇, 乔玮博, 赵惠民. 塑造低碳经济的第三代固碳生物炼制[J]. 合成生物学, 2020, 1(1): 44-59 DOI： 10.12211/2096-8280.2020-015.

SHI Shuobo, MENG Qiongyu, QIAO Weibo, ZHAO Huimin. Establishing carbon dioxide-based third-generation biorefinery for a sustainable low-carbon economy[J]. Synthetic Biology Journal, 2020, 1(1): 44-59 DOI： 10.12211/2096-8280.2020-015.

摘要

目前人类社会面临的两大挑战是如何实现非化石来源化学品和燃料的可持续生产以及如何应对大量二氧化碳排放造成的温室效应。第三代固碳生物炼制利用细胞工厂可将二氧化碳固定为一系列化学品和燃料，有望解决这一问题，从而建立以低能耗、低污染、低排放为基础的低碳经济模式。构建可利用二氧化碳的细胞工厂是迈向建立第三代固碳生物炼制平台的重要一步。随着生命科学的飞速发展，越来越多的二氧化碳固定机制被揭示。为了提高固碳效率，研究人员利用合成生物学改造天然固碳途径，并在此基础上设计人工固碳途径，或引入新颖的能源供应模式，甚至使异养模式生物变为合成自养生物。本文将对上述领域进行总结，并讨论微生物固定二氧化碳的主要挑战及其未来前景。

Abstract

Due to the sharply increased greenhouse gas (GHG) emissions

there is an urgent need to transit from the traditional ‘take-make-dispose’ economy to a sustainable economy with ecological balances through circular green technologies such as biorefineries. Based on the source of the feedstocks

existing biorefineries can be classified into three types: starch-based first-generation biorefinery

cellulosic biomass-based second-generation biorefinery

and carbon dioxide (CO

)-based third-generation biorefinery. Compared to the first- and second-generation biorefineries

the third-generation biorefinery will not only significantly reduce the GHG emissions but also have no issues on food and water security. However

one of the major challenges in establishing the third-generation

biorefinery is the design and engineering of microbial cell factories capable of efficiently utilizing CO

for the production of chemicals

fuels

and materials. In the past decades

a variety of CO

fixation pathways have been discovered in naturally occurring CO

fixation microorganisms (autotrophs) such as microalgae

cyanobacteria

and acetogens

and significant progress has been made in engineering these autotrophs to extend the product portfolio or improve the carbon fixation efficiencies. Recently

some of these CO

fixation pathways were successfully incorporated into heterotrophic microorganisms commonly used as microbial cell factories such as

Escherichia coli

and

Pichia pastoris

. In this review

we will first introduce both the naturally occurring and artificially designed CO

fixation pathways

and then discuss the application of synthetic biology strategies and tools for engineering autotrophs and heterotrophs to convert CO

into a variety of industrially important compounds. Finally

we will briefly comment on the prospects of CO

-based biorefinery and the relevant scientific opportunities and challenges.

关键词

Keywords

references

BIROL F . Key world energy statistics [M ] . Paris : IEA Publications , 2017 .

ZHOU Y J , KERKHOVEN E J , NIELSEN J . Barriers and opportunities in bio-based production of hydrocarbons [J ] . Nat. Energy. , 2018 , 3 : 925.

NOAA National Centers for Environmental information . Climate at a glance: global time series [EB/OL ] .[ 2020-02-08 ] . https://www.ncdc.noaa.gov/cag/ https://www.ncdc.noaa.gov/cag/ .

李慧明 . 《巴黎协定》与全球气候治理体系的转型 [J ] . 国际展望 , 2016 ( 2 ): 1-20.

LI H M . The Paris agreement and transition of the global climate governance system [J ] . Global Review , 2016 ( 2 ): 1-20.

United Nations Environment Programme . The emissions gap report 2019 [EB/OL ] . [ 2020-02-09 ] . https://wedocs.unep.org/bitstream/handle/20.500.11822/30797/EGR2019.pdf https://wedocs.unep.org/bitstream/handle/20.500.11822/30797/EGR2019.pdf .

谭天伟 , 俞建良 , 张栩 . 生物炼制技术研究新进展 [J ] . 化工进展， 2011 , 30 ( 1 ): 117-125.

TAN T W , YU J L , ZHANG X . Advance in biorefinery technology [J ] . Chemical Industry and Engineering Progress , 2011 , 30 ( 1 ): 117-125.

王凯 , 贺明丽 , 王梦 , 等 . 以 CO 2 为原料的绿色生物制造 [J ] . 化工进展 , 2019 , 38 ( 1 ): 538-544.

WANG K , HE M L , WANG M , et al . Green biological manufacture with CO 2 as raw material [J ] . Chemical Industry and Engineering Progress , 2019 , 38 ( 1 ): 538-544.

LIU Z , WANG K , CHEN Y , et al . Third-generation biorefineries as the means to produce fuels and chemicals f rom CO 2 [J ] . Nat. Catal. , 2020 , 3 : 274-288.

CLAASSENS N J , SOUSA D Z , DOS SANTOS V A M , et al . Harnessing the power of microbial autotrophy [J ] . Nat. Rev. Microbiol. , 2016 , 14 :692.

PALANKOEV T , DEMENTIEV K , KHADZHIEV S . Promising processes for producing drop-in biofuels and petrochemicals from renewable feedstock [J ] . Pet. Chem. , 2019 , 59 : 438-446.

MUSA S D , ZHONGHUA T , IBRAHIM A O , et al . China's energy status: A critical look at fossils and renewable options [J ] . Renewable Sustainable Energy Rev. , 2017 , 81 : 2281- 2290.

OU X , ZHANG X , ZHANG Q , et al . Life-cycle analysis of energy use and greenhouse gas emissions of gas-to-liquid fuel pathway from steel mill off-gas in China by the LanzaTech process [J ] . Front Energy , 2013 , 7 : 263-270.

LANE J . Algenol hits 9K gallons/acre mark for algae-to-ethanol process [J ] . Biofuels Digest ， 2013 . http://www.biofuelsdigest.com/bdigest/2013/03/11/algenol-hits-9k-gallonsacre-mark-for-algae-to-ethanol-process/ http://www.biofuelsdigest.com/bdigest/2013/03/11/algenol-hits-9k-gallonsacre-mark-for-algae-to-ethanol-process/ .

陈美球 , 蔡海生 . 低碳经济学 [M ] . 北京：清华大学出版社 , 2015 .

CHEN M Q , CAI H S . Low-carbon economics [M ] . Beijing : Tsinghua University Press , 2015 .

ELMEKAWY A , HEGAB H M , MOHANAKRISHNA G , et al . Technological advances in CO 2 conversion electro-biorefinery: a step toward commercialization [J ] . Bioresour Technol. , 2016 , 215 : 357.

BAR-EVEN A , NOOR E , MILO R . A survey of carbon fixation pathways through a quantitative lens [J ] . J. Exp. Bot. , 2012 , 63 :2325.

BERG I A , KOCKELKORN D , RAMOS-VERA W H , et al . Autotrophic carbon fixation in archaea [J ] . Nat. Rev. Microbiol. , 2010 , 8 : 447.

FAST A G , PAPOUTSAKIS E T . Stoichiometric and energetic analyses of non-photosynthetic CO 2 -fixation pathways to support synthetic biology strategies for production of fuels and chemicals [J ] . Curr. Opin. Chem. Eng. , 2012 , 1 : 380.

FUCHS G . Alternative pathways of carbon dioxide fixation: insights into the early evolution of life [J ] . Annu. Rev. Microbiol. , 2011 , 65 : 631.

HUMPHREYS C M , MINTON N P . Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas [J ] . Curr. Opin. Biotechnol. , 2018 , 50 : 174.

LIANG F , LINDBERG P , LINDBLAD P . Engineering photoautotrophic carbon fixation for enhanced growth and productivity [J ] . Sustainable Energy Fuels , 2018 , 2 : 2583.

LIAO J C , MI L , PONTRELLI S , et al . Fuelling the future: microbial engineering for the production of sustainable biofuels [J ] . Nat. Rev. Microbiol. , 2016 , 14 : 288-304.

YUNUS I S , WICHMANN J , WÖRDENWEBER R , et al . Synthetic metabolic pathways for photobiological conversion of CO 2 into hydrocarbon fuel [J ] . Metab. Eng. , 2018 , 49 :201-211.

WU Y , LI B Z , ZHAO M , et al . Bug mapping and fitness testing of chemically synthesized chromosome X [J ] . Science , 2017 , 355: eaaf4706 .

XIE Z X , LI B Z , MITCHELL L A , et al . “Perfect” designer chromosome V and behavior of a ring derivative [J ] . Science , 2017 , 355: eaaf4704.

YU T , ZHOU Y J , HUANG M , et al . Reprogramming yeast metabolism from alcoholic fermentation to lipogenesis [J ] . Cell , 2018 , 174 : 1549-1558.

BERG I A . Ecological aspects of the distribution of different autotrophic CO 2 fixation pathways [J ] . Appl. Environ. Microbiol. , 2011 , 77 : 1925.

CALVIN M , BENSON A A . The path of carbon in photosynthesis [J ] . Science , 1948 , 107 : 476.

SAGE R F . Variation in the k cat of Rubisco in C 3 and C 4 plants and some implications for photosynthetic performance at high and low temperature [J ] . J. Exp. Bot. , 2002 , 53 : 609.

VARALJAY V , SATAGOPAN S , NORTH J , et al . Functional metagenomic selection of RuBisCO from uncultivated bacteria [J ] . Environ. Microbiol. , 2015 , 18 : 1187.

DURÃO P , AIGNER H , NAGY P , et al . Opposing effects of folding and assembly chaperones on evolvability of Rubisco [J ] . Nat. Chem. Biol. , 2015 , 11 : 148.

CUMMINS P L , KANNAPPAN B , GREADY J E . Directions for optimization of photosynthetic carbon fixation: Rubisco's efficiency may not be so constrained after all [J ] . Front Plant Sci. , 2018 , 9 : 183.

BAR-EVEN A , FLAMHOLZ A , NOOR E , et al Thermodynamic constraints shape the structure of carbon fixation pathways [J ] . Biochim. Biophys. Acta. , 2012 , 1817 : 1646.

SCHUCHMANN K , MÜLLER V . Autotrophy at the thermodynamic limit of life: a model for energy conservation in acetogenic bacteria [J ] . Nat. Rev. Microbiol. , 2014 , 12 : 809-821.

KUMAR M , SUNDARAM S , GNANSOUNOU E , et al . Carbon dioxide capture, storage and production of biofuel and biomaterials by bacteria: a review [J ] . Bioresour Technol. , 2018 , 247 : 1059.

HÜGLER M , HUBER H , MOLYNEAUX S J , et al . Autotrophic CO 2 fixation via the reductive tricarboxylic acid cycle in different lineages within the phylum Aquificae : evidence for two ways of citrate cleavage [J ] . Environ Microbiol. , 2007 , 9 : 81-92.

MALL A , SOBOTTA J , HUBER C , et al . Reversibility of citrate synthase allows autotrophic growth of a thermophilic bacterium [J ] . Science , 2018 , 359 : 563.

NUNOURA T , CHIKARAISHI Y , IZAKI R , et al . A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile [J ] . Science , 2018 , 359 :559.

RAMOS-VERA W H , BERG I A , FUCHS G . Autotrophic carbon dioxide assimilation in Thermoproteales revisited [J ] . J . Bacteriol. , 2009 , 191 : 4286.

BLOCHL E . Pyrolobus fumarii , gen. and sp. nov., represents and novel group of archaea, extending the upper temperature limit for life to 113°C [J ] . Extremophiles , 1997 , 1 : 14-21.

FIGUEROA I A , BARNUM T P , SOMASEKHAR P Y , et al . Metagenomics-guided analysis of microbial chemolithoautotrophic phosphite oxidation yields evidence of a seventh natural CO 2 fixation pathway [J ] . PNAS , 2018 , 115 : E92-E101.

ISHII M , CHUAKRUT S , ARAI H , et al . Occurrence, biochemistry and possible biotechnological application of the 3-hydroxypropionate cycle [J ] . Appl. Microbiol. Biotechnol. , 2004 , 64 : 605.

HÜGLER M , MENENDEZ C , SCHÄGGER H , et al . Malonyl-coenzyme A reductase from Chloroflexus aurantiacus , a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO 2 fixation [J ] . J . Bacteriol. , 2002 , 184 : 2404.

ALBER B E , FUCHS G . Propionyl-coenzyme A synthase from Chloroflexus aurantiacus , a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO 2 fixation [J ] . J. Biol. Chem. , 2002 , 277 : 12137.

FAST A G , PAPOUTSAKIS E T . Functional expression of the Clostridium ljungdahlii acetyl-coenzyme A synthase in Clostridium acetobutylicum as demonstrated by a novel in vivo CO exchange activity en route to heterologous installation of a functional Wood-Ljungdahl pathway [J ] . Appl. Environ. Microbiol. , 2018 , 84 : 2307.

GONZALEZ DE LA CRUZ J , MACHENS F , Messerschmidt K , et al . Core catalysis of the reductive glycine pathway demonstrated in yeast [J ] . ACS Synth. Biol. , 2019 , 8 : 911.

YISHAI O , BOUZON M , DÖRING V , et al . In vivo assimilation of one-carbon via a synthetic reductive glycine pathway in Escherichia coli [J ] . ACS Synth. Biol. , 2018 , 7 : 2023.

BAR-EVEN A , NOOR E , LEWIS N E , et al . Design and analysis of synthetic carbon fixation pathways [J ] . PNAS , 2010 , 107 : 8889.

BOUZON M , PERRET A , LOREAU O , et al . A synthetic alternative to canonical one-carbon metabolism [J ] . ACS Synth. Biol. , 2017 , 6 : 1520.

SCHWANDER T , SCHADA VON BORZYSKOWSKI L , BURGENER S , et al . A synthetic pathway for the fixation of carbon dioxide in vitro [J ] . Science , 2016 , 354 : 900.

BOYLE N R , MORGAN J A . Computation of metabolic fluxes and efficiencies for biological carbon dioxide fixation [J ] . Metab. Eng. , 2011 , 13 : 150-158.

KIRST H , FORMIGHIERI C , MELIS A . Maximizing photosynthetic efficiency and culture productivity in cyanobacteria upon minimizing the phycobilisome light-harvesting antenna size [J ] . Biochim. Biophys. Acta-Bioenerg. , 2014 , 1837 : 1653-1664.

ZHOU J , ZHANG F , MENG H , et al . Introducing extra NADPH consumption ability significantly increases the photosynthetic efficiency and biomass production of cyanobacteria [J ] . Metab. Eng. , 2016 , 38 : 217-227.

MARTINEZ A , BRADLEY A , WALDBAUER J , et al . Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host [J ] . PNAS , 2007 , 104 : 5590-5595.

GUO J , SUÁSTEGUI M , SAKIMOTO K K , et al . Light-driven fine chemical production in yeast biohybrids [J ] . Science , 2018 , 362 : 813-816.

LAMONT C M , SARGENT F . Design and characterisation of synthetic operons for biohydrogen technology [J ] . Arch. Microbiol. , 2017 , 199 : 495.

LI H , OPGENORTH P H , WERNICK D G , et al . Integrated electromicrobial conversion of CO 2 to higher alcohols [J ] . Science , 2012 , 335 :1596.

WEI L , WANG Q , XIN Y , et al . Enhancing photosynthetic biomass productivity of industrial oleaginous microalgae by overexpression of RuBisCO activase [J ] . Algal. Res. , 2017 , 27 : 366-375.

DE MOOIJ T , JANSSEN M , CEREZO-CHINARRO O , et al . Antenna size reduction as a strategy to increase biomass productivity: a great potential not yet realized [J ] . J. Appl. Phycol. , 2015 , 27 : 1063-1077.

SHIN W S , LEE B , JEONG B R , et al . Truncated light-harvesting chlorophyll antenna size in Chlorella vulgaris improves biomass productivity [J ] . J. Appl. Phycol. , 2016 , 28 : 3193-3202.

LIANG F , LINDBLAD P . Effects of overexpressing photosynthetic carbon flux control enzymes in the cyanobacterium Synechocystis PCC 6803 [J ] . Metab. Eng. , 2016 ， 38 : 56-64.

KELLER M W , SCHUT G J , LIPSCOMB G L , et al . Exploiting microbial hyperthermophilicity to produce an industrial chemical, using hydrogen and carbon dioxide [J ] . PNAS , 2013 , 110 : 5840-5845.

MATTOZZI M D , ZIESACK M , VOGES M J , et al . Expression of the sub-pathways of the Chloroflexus aurantiacus 3-hydroxypropionate carbon fixation bicycle in E. coli : Toward horizontal transfer of autotrophic growth [J ] . Metab. Eng. , 2013 , 16 : 130-139.

GUO L , ZHANG F , ZHANG C , et al . Enhancement of malate production through engineering of the periplasmic rTCA pathway in Escherichia coli [J ] . Biotechnol. Bioeng. , 2018 , 115 : 1571-1580.

GUADALUPE-MEDINA V , WISSELINK H W , LUTTIK M A , et al . Carbon dioxide fixation by Calvin-Cycle enzymes improves ethanol yield in yeast [J ] . Biotechnol. Biofuels , 2013 , 6 : 125.

LI Y J , WANG M M , CHEN Y W , et al . Engineered yeast with a CO 2 -fixation pathway to improve the bio-ethanol production from xylose-mixed sugars [J ] . Sci. Rep. , 2017 , 7 : 43875.

ANTONOVSKY N , GLEIZER S , NOOR E , et al . Sugar synthesis from CO 2 in Escherichia coli [J ] . Cell , 2016 , 166 : 115-25.

GLEIZER S , BEN-NISSAN R , BAR-ON Y M , et al . Conversion of Escherichia coli to generate all biomass carbon from CO 2 [J ] . Cell , 2019 , 179 : 1255.

GASSLER T , SAUER M , GASSER B , et al . The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO 2 [J ] . Nat. Biotech. , 2019 . DOI: 10.103 8/s4 1587-019-0363-0 http://dx.doi.org/10.1038/s41587-019-0363-0 .

FERNÁNDEZ F G A , GONZÁLEZ-LÓPEZ C , SEVILLA J F , et al . Conversion of CO 2 into biomass by microalgae: how realistic a contribution may it be to significant CO 2 removal [J ] ? Appl. Microbiol. Biotechnol. , 2012 , 96 : 577.

MOAZAMI N , ASHORI A , RANJBAR R , et al . Large-scale biodiesel production using microalgae biomass of Nannochloropsis [J ] . Biomass Bioenergy , 2012 , 39 : 449.

KIM H M , OH C H , BAE H J . Comparison of red microalgae ( Porphyridium cruentum ) culture conditions for bioethanol production [J ] . Bioresour. Technol. , 2017 , 233 : 44-50.

REYIMU Z , ÖZÇIMEN D . Batch cultivation of marine microalgae Nannochloropsis oculata and Tetraselmis suecica in treated municipal wastewater toward bioethanol production [J ] . J. Cleaner Prod. , 2017 , 150 : 40.

KOSOUROV S , JOKEL M , ARO E M , et al . A new approach for sustained and efficient H 2 photoproduction by Chlamydomonas reinhardtii [J ] . Energy Environ. Sci. , 2018 , 11 : 1431-1436.

CHERAD R , ONWUDILI J , BILLER P , et al . Hydrogen production from the catalytic supercritical water gasification of process water generated from hydrothermal liquefaction of microalgae [J ] . Fuel , 2016 , 166 : 24-28.

CHEN J H , CHEN C Y , HASUNUMA T , et al . Enhancing lutein production with mixotrophic cultivation of Chlorella sorokiniana MB-1-M12 using different bioprocess operation strategies [J ] . Bioresour. Technol. , 2019 , 278 : 17-25.

GONG M , BASSI A . Carotenoids from microalgae: A review of recent developments [J ] . Biotechnol. Adv. , 2016 , 34 : 1396-1412.

SAINI D K , CHAKDAR H , PABBI S , et al . Enhancing production of microalgal biopigments through metabolic and genetic engineering [J ] . Crit. Rev. Food. Sci. Nutr. , 2020 , 60 : 391-405.

RADAKOVITS R , EDUAFO P M , POSEWITZ M C . Genetic engineering of fatty acid chain length in Phaeodactylum tricornutum [J ] . Metab. Eng. , 2011 , 13 : 89-95.

XIN Y , LU Y , LEE Y Y , et al . Producing designer oils in industrial microalgae by rational modulation of co-evolving type-2 diacylglycerol acyltransferases [J ] . Mol. Plant , 2017 , 10 : 1523-1539.

POURMIR A , NOOR-MOHAMMADI S , JOHANNES T W . Production of xylitol by recombinant microalgae [J ] . J. Biotechnol. , 2013 , 165 : 178-183.

LAUERSEN K J , BAIER T , WICHMANN J , et al . Efficient phototrophic production of a high-value sesquiterpenoid from the eukaryotic microalga Chlamydomonas reinhardtii [J ] . Metab. Eng. , 2016 , 38 : 331-343.

TRAN M , ZHOU B , PETTERSSON P L , et al . Mayfield SP. Synthesis and assembly of a full‐length human monoclonal antibody in algal chloroplasts [J ] . Biotechnol. Bioeng. , 2009 , 104 : 663-673.

GREGORY J A , LI F , TOMOSADA L M , et al . Algae-produced Pfs25 elicits antibodies that inhibit malaria transmission [J ] . PLoS One , 2012 , 7 : e37179.

WANG W , YU L J , XU C , et al . Structural basis for blue-green light harvesting and energy dissipation in diatoms [J ] . Science , 2019 , 363: eaav0365.

JAJESNIAK P , ALI H E M O , WONG T S . Carbon dioxide capture and utilization using biological systems: opportunities and challenges [J ] . J. Bioprocess Biotech. , 2014 , 4 : 3.

LEE T C , XIONG W , PADDOCK T , et al . Engineered xylose utilization enhances bio-products productivity in the cyanobacterium Synechocystis sp. PCC 6803 [J ] . Metab. Eng. , 2015 , 30 : 179-1 89.

XIONG W , MORGAN J A , UNGERER J , et al . The plasticity of cyanobacterial metabolism supports direct CO 2 conversion to ethylene [J ] . Nat. Plants , 2015 , 1 : 15053.

LEE H J , CHOI J , LEE S M , et al . Photosynthetic CO 2 conversion to fatty acid ethyl esters (FAEE) using engineered cyanobacteria [J ] . J. Agric. Food Chem. , 2017 , 65 : 1087-1092.

OLIVER J W , MACHADO I M , YONEDA H , et al . Cyanobacterial conversion of carbon dioxide to 2, 3-butanediol [J ] . PNAS , 2013 , 110 : 1249-1254.

LAI M J , LAN E I . Photoautotrophic synthesis of butyrate by metabolically engineered cyanobacteria [J ] . Biotechnol. Bioeng. , 2019 , 116 : 893-903.

NI J , TAO F , WANG Y , et al . A photoautotrophic platform for the sustainable production of valuable plant natural products from CO 2 [J ] . Green Chem. , 2016 , 18 : 3537-3548.

WANG Y , TAO F , NI J , et al . Production of C 3 platform chemicals from CO 2 by genetically engineered cyanobacteria [J ] . Green Chem. , 2015 , 17 : 3100-3110.

NI J , LIU H Y , TAO F , et al . Remodeling of the photosynthetic chain promotes direct CO 2 conversion into valuable aromatic compounds [J ] . Angew. Chem. , 2018 , 130 : 16222-16226.

NÜRNBERG D J , MORTON J , SANTABARBARA S , et al . Photochemistry beyond the red limit in chlorophyll f-containing photosystems [J ] . Science , 2018 , 360 : 1210-1213.

LIANG F , ENGLUND E , LINDBERG P , et al . Engineered cyanobacteria with enhanced growth show increased ethanol production and higher biofuel to biomass ratio [J ] . Metab. Eng. , 2018 , 46 : 51-59.

DE PORCELLINIS A J , NØRGAARD H , BREY L M F , et al . Overexpression of bifunctional fructose-1,6-bisphosphatase/sedoheptulose-1,7-bisphosphatase leads to enhanced photosynthesis and global reprogramming of carbon metabolism in Synechococcus sp. PCC 7002 [J ] . Metab. Eng. , 2018 , 47 : 170-183.

SU H Y , CHOU H H , CHOW T J , et al . Improvement of outdoor culture efficiency of cyanobacteria by over-expression of stress tolerance genes and its implication as bio-refinery feedstock [J ] . Bioresour. Technol. , 2017 , 244 : 1294-1303.

MORENO J I , MARTÍN R , CASTRESANA C . Arabidopsis SHMT1, a serine hydroxymethyltransferase that functions in the photorespiratory pathway influences resistance to biotic and abiotic stress [J ] . Plant J. , 2005 , 41 : 451-463.

WADITEE-SIRISATTHA R , KAGEYAMA H , TANAKA Y , et al . Overexpression of halophilic serine hydroxymethyltransferase in fresh water cyanobacterium Synechococcus elongatus PCC7942 results in increased enzyme activities of serine biosynthetic pathways and enhanced salinity tolerance [J ] . Arch. Microbiol. , 2017 , 199 : 29-35.

CHENG C , LI W , LIN M , et al . Metabolic engineering of Clostridium carboxidivorans for enhanced ethanol and butanol production from syngas and glucose [J ] . Bioresour Technol. , 2019 , 284 : 415-423.

HUANG H , CHAI C , YANG S , et al . Phage serine integrase-mediated genome engineering for efficient expression of chemical biosynthetic pathway in gas-fermenting Clostridium ljungdahlii [J ] . Metab. Eng. , 2019 , 52 : 29 3-302.

KHAN N E , MYERS J A , TUERK A L , et al . A process economic assessment of hydrocarbon biofuels production using chemoautotrophic organisms [J ] . Bioresour Technol. , 2014 , 172 : 201-211.

AMMAM F , TREMBLAY P L , LIZAK D M , et al . Effect of tungstate on acetate and ethanol production by the electrosynthetic bacterium Sporomusa ovata [J ] . Biotechnol. Biofuels. , 2016 , 9 : 163.

BAJRACHARYA S , VANBROEKHOVEN K , BUISMAN C J N , et al . Bioelectrochemical conversion of CO 2 to chemicals: CO 2 as a next generation feedstock for electricity-driven bioproduction in batch and continuous modes [J ] . Faraday Discuss. , 2017 , 202 : 433-449.

VASSILEV I , HERNANDEZ P A , BATLLE-VILANOVA P , et al . Microbial electrosynthesis of isobutyric, butyric, caproic acids, and corresponding alcohols from carbon dioxide [J ] . ACS Sustainable Chem. Eng. , 2018 , 6 : 8485-8493.

LA BELLE E V , MAY H D . Energy efficiency and productivity enhancement of microbial electrosynthesis of acetate [J ] . Front Microbiol. , 2017 , 8 : 756.

GANIGUÉ R , PUIG S , BATLLE-VILANOVA P , et al . Microbial electrosynthesis of butyrate from carbon dioxide [J ] . Chem. Commun. , 2015 , 51 : 3235-3238.

JOURDIN L , RAES S M , BUISMAN C J , et al . Critical biofilm growth throughout unmodified carbon felts allows continuous bioelectrochemical chain elongation from CO 2 up to caproate at high current density [J ] . Front Energy Res. , 2018 , 6 : 7.

HAAS T , KRAUSE R , WEBER R , et al . Technical photosynthesis involving CO 2 electrolysis and fermentation [J ] . Nat. Catal. , 2018 , 1 : 32.

全球首套工业装置——高效清洁 [EB/OL ] . [ 2020-02-16 ] . http://www.bjsgltne.com/odds http://www.bjsgltne.com/odds .

The first industrial device in the world high efficiency cleaning [EB/OL ] . [ 2020-02-16 ] . http://www.bjsgltne.com/odds http://www.bjsgltne.com/odds .

LIU Y , WHITMAN W B . Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea [J ] . Ann . N. Y. Acad. Sci., 2008, 1125: 171-189.

KAWAGUCHI H , SAKUMA T , NAKATA Y , et al . Methane production by Methanothermobacter thermautotrophicus to recover energy from carbon dioxide sequestered in geological reservoirs [J ] . J. Biosci. Bioeng. , 2010 , 110 : 106-108.

LIU C , MAO L , ZHENG X , et al . Comparative proteomic analysis of Methanothermobacter thermautotrophicus reveals methane formation from H 2 and CO 2 under different temperature conditions [J ] . MicrobiologyOpen , 2019 , 8 : e00715.

BASEN M , SUN J , ADAMS M W W . Engineering a hyperthermophilic archaeon for temperature-dependent product formation [J ] . mBio. , 2012 , 3 : e00053-12.

BASEN M , SCHUT G J , NGUYEN D M , et al . Single gene insertion drives bioalcohol production by a thermophilic archaeon [J ] . PNAS , 2014 , 111 : 17618-17623.

KELLER M W , LIPSCOMB G L , LODER A J , et al . A hybrid synthetic pathway for butanol production by a hyperthermophilic microbe [J ] . Metab. Eng. , 2015 , 27 : 101-106.

BOWIEN B , KUSIAN B . Genetics and control of CO 2 assimilation in the chemoautotroph Ralstonia eutropha [J ] . Arch. Microbiol. , 2002 , 178 : 85-93.

SATAGOPAN S , TABITA F R . RubisCO selection using the vigorously aerobic and metabolically versatile bacterium Ralstonia eutropha [J ] . FEBS J. , 2016 , 283 : 2869-2880.

PRZYBYLSKI D , ROHWERDER T , DILßNER C , et al . Exploiting mixtures of H 2 , CO 2 , and O 2 for improved production of methacrylate precursor 2-hydroxyisobutyric acid by engineered Cupriavidus necator strains [J ] . Appl. Microbiol. Biotechnol. , 2015 , 99 : 2131-2145.

MÜLLER J , MACEACHRAN D , BURD H , et al . Engineering of Ralstonia eutropha H16 for autotrophic and heterotrophic production of methyl ketones [J ] . Appl. Environ. Microbiol. , 2013 , 79 : 4433-4439.

GARRIGUES L , MAIGNIEN L , LOMBARD E , et al . Isopropanol production from carbon dioxide in Cupriavidus necator in a pressurized bioreactor [J ] . New Biotechnol. , 2020 , 56 : 16-20.

LI Z , XIONG B , LIU L , et al . Development of an autotrophic fermentation technique for the production of fatty acids using an engineered Ralstonia eutropha cell factory [J ] . J. Ind. Microbiol. Biotechnol. , 2019 , 46 : 783-790.

CRÉPIN L , LOMBARD E , GUILLOUET S E . Metabolic engineering of Cupriavidus necator for heterotro -phic and autotrophic alka(e)ne production [J ] . Metab. Eng. , 2016 , 37 : 92-101.

SCHLEGEL H , LAFFERTY R . The production of biomass from hydrogen and carbon dioxide [J ] . Adv. Biochem. Eng. , 1971 , 1 : 143-168.

LÜTTE S , POHLMANN A , ZAYCHIKOV E , et al . Autotrophic production of stable-isotope-labeled arginine in Ralstonia eutropha strain H16 [J ] . Appl. Environ. Microbiol. , 2012 , 78 : 7884-7890.

MARC J , GROUSSEAU E , LOMBARD E , et al . Over expression of GroESL in Cupriavidus necator for heterotrophic and autotrophic isopropanol production [J ] . Metab. Eng. , 2017 , 42 : 74-84.

KRUYER N S , PERALTA-YAHYA P . Advancing the potential for the production of chemicals from carbon dioxide in Escherichia coli [J ] . Biochemistry , 2020 , 59 : 731-732.

SHEN Y . Carbon dioxide bio-fixation and wastewater treatment via algae photochemical synthesis for biofuels production [J ] . RSC Adv. , 2014 , 4 : 49672-49722.

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