Policy planning and industrial development of agricultural synthetic biology

ZHANG Xuebo; ZHU Chengshu; CHEN Ruiyun; JIN Qingzi; LIU Xiao; XIONG Yan; CHEN Daming

doi:10.12211/2096-8280.2025-066

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Policy planning and industrial development of agricultural synthetic biology

Invited Review | 更新时间：2025-11-12

- Policy planning and industrial development of agricultural synthetic biology
- Synthetic Biology Journal Vol. 6, Issue 5, Pages: 1224-1242(2025)
- 作者机构：
  
  1.中国科学院上海生命科学信息中心，中国科学院上海营养与健康研究所，上海 200031
  2.中国科学院大学，北京 100049
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2025-066
  CLC： Q-1;Q81
- Received：25 June 2025，
  
  Revised：2025-08-28，
  
  Published：31 October 2025
- 稿件说明：
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张学博，朱成姝，陈睿雲，金庆姿，刘晓，熊燕，陈大明. 农业合成生物学：政策规划与产业发展协同推进［J］. 合成生物学， 2025， 6（5）： 1224-1242

ZHANG Xuebo， ZHU Chengshu， CHEN Ruiyun， JIN Qingzi， LIU Xiao， XIONG Yan， CHEN Daming. Policy planning and industrial development of agricultural synthetic biology［J］. Synthetic Biology Journal， 2025， 6（5）： 1224-1242
张学博，朱成姝，陈睿雲，金庆姿，刘晓，熊燕，陈大明. 农业合成生物学：政策规划与产业发展协同推进［J］. 合成生物学， 2025， 6（5）： 1224-1242 DOI： 10.12211/2096-8280.2025-066.

ZHANG Xuebo， ZHU Chengshu， CHEN Ruiyun， JIN Qingzi， LIU Xiao， XIONG Yan， CHEN Daming. Policy planning and industrial development of agricultural synthetic biology［J］. Synthetic Biology Journal， 2025， 6（5）： 1224-1242 DOI： 10.12211/2096-8280.2025-066.

摘要

农业合成生物学作为融合生物学、工程学与计算机科学的交叉学科，通过创新设计与改造生物系统，推动农业生产向更高效、可持续的方向发展。其进步不仅依赖技术创新，更需政策规划与产业需求的动态适配。近年来，全球各国政府通过政策制定、创新激励与产业促进，加速推进该领域的发展。政策方面，美国、欧盟、英国及澳大利亚等国家和地区，通过顶层设计和配套措施，支持基因编辑、代谢工程等关键技术在农业领域的研发与应用。我国亦积极构建产学研一体化的创新生态系统，加速农业合成生物技术的创新与产业化进程。产业方面，在政策引导下，创新技术已在育种、食品与饲料、生物农药等细分领域实现初步商业化。本文基于农业合成生物学的创新链与产业链，系统梳理国内外相关政策规划与产业发展现状，并聚焦作物改良、抗逆性提升及原材料开发等重点方向，解析农业合成生物学“技术驱动-中试验证-产业转化”链条中的关键环节，以期为破解产业化瓶颈、优化资源配置、激发市场主体活力提供参考路径，从而加快我国农业生物技术创新成果转化进程，保障国家粮食安全与生态安全，全面提升我国农业领域的国际竞争力与可持续发展能力。

Abstract

Agricultural synthetic biology

an emerging interdisciplinary field

synergistically integrates fundamental principles from biology

engineering and computer science

and is dedicated to advancing agricultural production towards greater efficiency and sustainability by innovatively designing and engineering of biological systems. In recent years

governments worldwide have accelerated the development of this field through the combined efforts of policy initiatives and technological innovation. Countries and regions including the United States

the European Union

the United Kingdom

and Australia have introduced policies to explicitly support the research and application of key technologies

such as gene editing and metabolic engineering

in the agricultural field. These supportive frameworks have greatly advanced the global development of agricultural synthetic biology. In China

active efforts are being made to construct an integrated innovation ecosystem connecting industry

academia

and research institutions

with the goal of accelerating the industrialization of agricultural synthetic biology technologies. Currently

several technologies have achieved initial commercial applications in areas such as breeding

food and feed production

and biological pesticides. In crop breeding

precise genome editing enables the development of varieties with enhanced yield

improved nutritional quality

and greater resistance to biotic and abiotic stresses. In the field of food and feed

genetic engineering is employed to modify microorganisms to produce enzyme preparations that improve feed digestibility and nutritional value

as well as to develop microbial-based biopreservatives to replace chemical preservatives

or natural-source coatings that extend the shelf life of fruits and vegetables. Additionally

biological pesticides derived from natural microorganisms

plant extracts or insect pheromones can effectively reduce the impact on soil

water sources and ecosystems

while reducing the risk of residues. These products are increasingly applied in crop protection

and offer sustainable alternatives for reducing environmental pollution while safeguarding food safety. Several innovative enterprises worldwide have provided valuable experience and insights into the development and application of agricultural microbial products. These companies not only demonstrate effective pathways for translating laboratory research into practical products

but also offer business models that serve as valuable references for the broader industry. Simultaneously

a number of Chinese enterprises are actively exploring the application of synthetic biology to improve crop breeding

enhance crop resistance to stress and diseases

and develop biopesticides

biofertilizers

and new bio-based materials. Some are employing synthetic biology approaches to improve crop performance under adverse environmental conditions or to enhance soil health by optimizing microbial community structures. Despite recent breakthroughs

the continued development of agricultural synthetic biology still faces numerous challenges

including limited market acceptance

underdeveloped regulatory frameworks

insufficient capital investments

and persistent technological bottlenecks. Overcoming these challenges requires a concerted

multi-faceted approach that integrates policy guidance

technological innovation

and industrial upgrading. It is essential to foster synergistic development across key domains

including the engineering of non-food crops

the expansion of photoautotrophic microbial platforms

and the advancement of carbon capture and utilization technologies. At the same time

interdisciplinary collaboration should be strengthened to encourage more research institutions and enterprises to engage in this field. Through the combined forces of supportive policies and increased capital investment

barriers such as ecological risk assessment can be effectively addressed

thereby accelerating the commercialization of new products. Governments must act promptly to establish clear

science-based regulatory pathways that ensure the safety and efficacy of emerging agricultural biotechnologies

at the same time investors should recognize the transformative potential of this field and provide financial support for startups and research initiatives. Ultimately

the goal is to catalyze a global agricultural transformation that ensures food security for a growing population

mitigates the impacts of climate change

and promotes ecological conservation and restoration. Through collaborative efforts among all stakeholders

agricultural synthetic biology has the potential to become a driving force for advancing modern agriculture and building a greener

healthier

and more sustainable future for humanity.

关键词

Keywords

references

WANG L T , ZANG X , ZHOU J H . Synthetic biology: a powerful booster for future agriculture [J ] . Advanced Agrochem , 2022 , 1 ( 1 ): 7 - 11 .

VILLIGER L , JOUNG J , KOBLAN L , et al . CRISPR technologies for genome, epigenome and transcriptome editing [J ] . Nature Reviews Molecular Cell Biology , 2024 , 25 ( 6 ): 464 - 487 .

RUAN S P , JIANG Y C , WANG A X , et al . Carbon sequestration pathways in microorganisms: advances, strategies, and applications [J ] . Engineering Microbiology , 2025 , 5 ( 2 ): 100196 .

GALINDO F S , PAGLIARI P H , DA SILVA E C , et al . Impact of nitrogen fertilizer sustainability on corn crop yield: the role of beneficial microbial inoculation interactions [J ] . BMC Plant Biology , 2024 , 24 ( 1 ): 268 .

YE X Y , QIN K Z , FERNIE A R , et al . Prospects for synthetic biology in 21st century agriculture [J ] . Journal of Genetics and Genomics , 2025 , 52 ( 8 ): 967 - 986 .

ZHU Y G , PENG J J , CHEN C , et al . Harnessing biological nitrogen fixation in plant leaves [J ] . Trends in Plant Science , 2023 , 28 ( 12 ): 1391 - 1405 .

GOOLD H D , WRIGHT P , HAILSTONES D . Emerging opportunities for synthetic biology in agriculture [J ] . Genes , 2018 , 9 ( 7 ): 341 .

PURNICK P E M , WEISS R . The second wave of synthetic biology: from modules to systems [J ] . Nature Reviews Molecular Cell Biology , 2009 , 10 ( 6 ): 410 - 422 .

YASMEEN E , WANG J , RIAZ M , et al . Designing artificial synthetic promoters for accurate, smart, and versatile gene expression in plants [J ] . Plant Communications , 2023 , 4 ( 4 ): 100558 .

RADIVOJEVIĆ T , COSTELLO Z , WORKMAN K , et al . A machine learning Automated Recommendation Tool for synthetic biology [J ] . Nature Communications , 2020 , 11 : 4879 .

BROWN D M , PHILLIPS D A , GARCIA D C , et al . Semiautomated production of cell-free biosensors [J ] . ACS Synthetic Biology , 2025 , 14 ( 3 ): 979 - 986 .

CHI H T , WANG X L , SHAO Y , et al . Engineering and modification of microbial chassis for systems and synthetic biology [J ] . Synthetic and Systems Biotechnology , 2019 , 4 ( 1 ): 25 - 33 .

LI G T , AN L N , YANG W N , et al . Integrated biotechnological and AI innovations for crop improvement [J ] . Nature , 2025 , 643 ( 8073 ): 925 - 937 .

GAO C X . Genome engineering for crop improvement and future agriculture [J ] . Cell , 2021 , 184 ( 6 ): 1621 - 1635 .

XU Y B , ZHANG X P , LI H H , et al . Smart breeding driven by big data, artificial intelligence, and integrated genomic-enviromic prediction [J ] . Molecular Plant , 2022 , 15 ( 11 ): 1664 - 1695 .

MA Y X , ZHANG Z Y , JIA B , et al . Automated high-throughput DNA synthesis and assembly [J ] . Heliyon , 2024 , 10 ( 6 ): e26967 .

ZHANG D L , XU F , WANG F H , et al . Synthetic biology and artificial intelligence in crop improvement [J ] . Plant Communications , 2025 , 6 ( 2 ): 101220 .

ZHAO Z H , FERNIE A R , ZHANG Y J . Engineering nitrogen and carbon fixation for next-generation plants [J ] . Current Opinion in Plant Biology , 2025 , 85 : 102699 .

GAO F , LI P , YIN Y , et al . Molecular breeding of livestock for disease resistance [J ] . Virology , 2023 , 587 : 109862 .

SOLER-NAVARRO D J , TENZA-PERAL A , JANSSEN M A , et al . Environmental strategies increase the resilience of extensive livestock systems to adverse climate conditions [J ] . Journal of Environmental Management , 2025 , 388 : 126004 .

BELL M J . Breeding a sustainable future for milk production [J ] . NPJ Sustainable Agriculture , 2024 , 2 : 18 .

XU R , CHEN J W , YAN N N , et al . High-value utilization of agricultural residues based on component characteristics: potentiality and challenges [J ] . Journal of Bioresources and Bioproducts , 2025 , 10 ( 3 ): 271 - 294 .

SUDHEER S , BAI R G , USMANI Z , et al . Insights on engineered microbes in sustainable agriculture: biotechnological developments and future prospects [J ] . Current Genomics , 2020 , 21 ( 5 ): 321 - 333 .

MAT JALALUDDIN N S , OTHMAN R Y , HARIKRISHNA J A . Global trends in research and commercialization of exogenous and endogenous RNAi technologies for crops [J ] . Critical Reviews in Biotechnology , 2019 , 39 ( 1 ): 67 - 78 .

CHEMLA Y , SWEENEY C J , WOZNIAK C A , et al . Design and regulation of engineered bacteria for environmental release [J ] . Nature Microbiology , 2025 , 10 ( 2 ): 281 - 300 .

WURTZEL E T , VICKERS C E , HANSON A D , et al . Revolutionizing agriculture with synthetic biology [J ] . Nature Plants , 2019 , 5 ( 12 ): 1207 - 1210 .

SHARMA K , SHIVANDU S K . Integrating artificial intelligence and Internet of Things (IoT) for enhanced crop monitoring and management in precision agriculture [J ] . Sensors International , 2024 , 5 : 100292 .

LI B S , SUN C , LI J Y , et al . Targeted genome-modification tools and their advanced applications in crop breeding [J ] . Nature Reviews Genetics , 2024 , 25 ( 9 ): 603 - 622 .

Synthetic Biology Engineering Research Center (SynBERC) . Award abstract #0540879 [EB/OL ] . ( 2006-07-14 )[ 2025-08-28 ] . https://www.nsf.gov/awardsearch/showAward?AWD_ID=0540879 https://www.nsf.gov/awardsearch/showAward?AWD_ID=0540879 .

Policy challenges of accelerating technological change: security policy and strategy implications of parallel scientific revolutions [EB/OL ] . ( 2014-09-01 )[ 2025-06-09 ] . https://digitalcommons.ndu.edu/defense-tech-papers/3/ https://digitalcommons.ndu.edu/defense-tech-papers/3/ .

美国国家科学院研究理事会 . 生物工业化路线图: 加速化学品的先进制造 [M ] . 陈方, 丁陈君, 刘斌, 译. 北京 : 科学出版社 , 2017 .

United States National Research Council . Industrialization of biology: a roadmap to accelerate the advanced manufacturing of chemicals [M ] . CHEN F, DING C J, LIU B, translated. Beijing : Science Press , 2017 .

USDA . Establishing the national bioengineered food disclosure standard [EB/OL ] . ( 2018-12-20 )[ 2025-06-15 ] . https://www.usda.gov/about-usda/news/press-releases/2018/12/20/establishing-national-bioengineered-food-disclosure-standard https://www.usda.gov/about-usda/news/press-releases/2018/12/20/establishing-national-bioengineered-food-disclosure-standard .

USDA . Plant genetic resources, genomics and genetic improvement [EB/OL ] . ( 2024-04-11 )[ 2025-06-15 ] . https://www.ars.usda.gov/crop-production-and-protection/plant-genetic-resources-genomics-and-genetic-improvement/ https://www.ars.usda.gov/crop-production-and-protection/plant-genetic-resources-genomics-and-genetic-improvement/ .

SERVIVK K . Trump’s agriculture department reverses course on biotech rules [N/OL ] . ( 2017-11-06 )[ 2025-06-16 ] . https://www.science.org/content/article/trump-s-agriculture-department-reverses-course-biotech-rules https://www.science.org/content/article/trump-s-agriculture-department-reverses-course-biotech-rules .

EBRC . Engineering Biology ( 2019 ) A research roadmap for the next-generation bioeconomy [EB/OL ] . ( 2019-06-01 )[ 2025-08-28 ] . https://roadmap.ebrc.org/2019roadmap/ https://roadmap.ebrc.org/2019roadmap/ .

OSTP . FACT SHEET: Biden-⁠Harris administration announces new bold goals and priorities to advance American biotechnology and biomanufacturing [EB/OL ] . ( 2023-03-22 )[ 2025-05-15 ] . https://bidenwhitehouse.archives.gov/ostp/news-updates/2023/03/22/fact-sheet-biden-harris-administration-announces-new-bold-goals-and-priorities-to-advance-american-biotechnology-and-biomanufacturing/ https://bidenwhitehouse.archives.gov/ostp/news-updates/2023/03/22/fact-sheet-biden-harris-administration-announces-new-bold-goals-and-priorities-to-advance-american-biotechnology-and-biomanufacturing/ .

U.S.Senate . Synthetic biology advancement act of 2024 [EB/OL ] . ( 2024-05-23 )[ 2025-06-17 ] . https://www.govinfo.gov/app/details/BILLS-118s4413is https://www.govinfo.gov/app/details/BILLS-118s4413is .

NSCEB . Charting the future of biotechnology [EB/OL ] . ( 2025-04-10 )[ 2025-06-20 ] . https://www.biotech.senate.gov/final-report/chapters/ https://www.biotech.senate.gov/final-report/chapters/ .

USDA . National program 301: plant genetic resources, genomics and genetic improvement [EB/OL ] . [ 2025-05-09 ] . https://www.ars.usda.gov/ARSUserFiles/np301/NP%20301%20Action%20Plan%202018-2022%20FINAL.pdf https://www.ars.usda.gov/ARSUserFiles/np301/NP%20301%20Action%20Plan%202018-2022%20FINAL.pdf .

Executive order on advancing biotechnology and biomanufacturing innovation for a sustainable , safe , and secure American bioeconomy [EB/OL ] . ( 2022-09-12 )[ 2025-06-07 ] . https://bidenwhitehouse.archives.gov/briefing-room/presidential-actions/2022/09/12/executive-order-on-advancing-biotechnology-and-biomanufacturing-innovation-for-a-sustainable-safe-and-secure-american-bioeconomy/ https://bidenwhitehouse.archives.gov/briefing-room/presidential-actions/2022/09/12/executive-order-on-advancing-biotechnology-and-biomanufacturing-innovation-for-a-sustainable-safe-and-secure-american-bioeconomy/ .

EBRC . Engineering biology: a research roadmap for the next-generation bioeconomy [EB/OL ] . ( 2019-06 )[ 2025-06-09 ] . https://roadmap.ebrc.org https://roadmap.ebrc.org .

118th Congress . S . 4413 - Synthetic biology advancement act of 2024 [EB/OL ] . ( 2024-05-23 )[ 2025-06-11 ] . https://www.congress.gov/bill/118th-congress/senate-bill/4413 https://www.congress.gov/bill/118th-congress/senate-bill/4413 .

CALLAWAY E . CRISPR plants now subject to tough GM laws in European Union [J ] . Nature , 2018 , 560 ( 7716 ): 16 .

Directive 2001/18/EC of the European Parliament and of the Council of 12 March 2001 on the deliberate release into the environment of genetically modified organisms and repealing Council Directive 90 / 220/EEC [J ] . Official Journal of the European Communities , 2001, 44 ( 106 ): 1 - 39 .

Regulation (EC) No 1829 / 2003 on genetically modified food and feed [J ] . Official Journal of the European Union , 2023 , 46 ( 268 ): 1 - 23 .

2007: Landmark European publication behind ‘Knowledge Based Bioeconomy’ in Europe [EB/OL ] .( 2021-06-18 ) [ 2025-04-10 ] . https://www.europabio.org/timeline/2007-landmark-european-publication-behind-knowledge-based-bioeconomy-in-europe/ https://www.europabio.org/timeline/2007-landmark-european-publication-behind-knowledge-based-bioeconomy-in-europe/ .

The knowledge based bio-economy (KBBE) in europe: achievements and challenges [EB/OL ] . ( 2010-09-14 )[ 2025-05-15 ] . https://www.vlaanderen.be/publicaties/the-knowledge-based-bio-economy-kbbe-in-europe-achievements-and-challenges https://www.vlaanderen.be/publicaties/the-knowledge-based-bio-economy-kbbe-in-europe-achievements-and-challenges .

ERASynBio . Next steps for European synthetic biology: a strategic vision from ERASynBio [EB/OL ] . [ 2025-04-20 ] . https://haseloff.plantsci.cam.ac.uk/resources/SynBio_reports/erasynbiostrategicvision.pdf https://haseloff.plantsci.cam.ac.uk/resources/SynBio_reports/erasynbiostrategicvision.pdf .

Horizon 2020 : the EU’s research and innovation programme ( 2014-20 ) [EB/OL ] . [ 2025-06-17 ] . https://eur-lex.europa.eu/EN/legal-content/summary/horizon-2020-the-eu-s-research-and-innovation-programme-2014-20.html https://eur-lex.europa.eu/EN/legal-content/summary/horizon-2020-the-eu-s-research-and-innovation-programme-2014-20.html .

A sustainable bioeconomy for Europe-strengthening the connection between economy , society and the environment: updated bioeconomy strategy [EB/OL ] . ( 2018-10-12 )[ 2025-06-15 ] . https://knowledge4policy.ec.europa.eu/publication/sustainable-bioeconomy-europe-strengthening-connection-between-economy-society_en https://knowledge4policy.ec.europa.eu/publication/sustainable-bioeconomy-europe-strengthening-connection-between-economy-society_en .

Farm to fork strategy: for a fair, healthy and environmentally-friendly food system [EB/OL ] . [ 2025-06-25 ] . https://food.ec.europa.eu/horizontal-topics/farm-fork-strategy_en https://food.ec.europa.eu/horizontal-topics/farm-fork-strategy_en .

Current and future market applications of new genomic techniques [EB/OL ] . ( 2021-05-05 )[ 2025-06-17 ] . https://knowledge4policy.ec.europa.eu/visualisation/new-genomic-techniques_en https://knowledge4policy.ec.europa.eu/visualisation/new-genomic-techniques_en .

“ Horizon Europe” research programme [EB/OL ] . [ 2025-05-06 ] . https://www.ese-hormones.org/what-we-do/research/european-research-funding/funding-programmes/horizon-europe/horizon-europe-programme-overview/ https://www.ese-hormones.org/what-we-do/research/european-research-funding/funding-programmes/horizon-europe/horizon-europe-programme-overview/

EFSA Panel on Genetically Modified Organisms GMO) , MULLINS E , BRESSON J L , et al . Evaluation of existing guidelines for their adequacy for the food and feed risk assessment of genetically modified plants obtained through synthetic biology [J ] . EFSA Journal , 2022 , 20 ( 7 ): e07410 .

New techniques in biotechnology [EB/OL ] . ( 2023-07-05 )[ 2025-08-01 ] . https://food.ec.europa.eu/plants/genetically-modified-organisms/new-techniques-biotechnology_en https://food.ec.europa.eu/plants/genetically-modified-organisms/new-techniques-biotechnology_en .

Building the future with nature: boosting biotechnology and biomanufacturing in the EU [EB/OL ] . ( 2023-03-27 )[ 2025-06-18 ] . https://research-and-innovation.ec.europa.eu/document/download/47554adc-dffc-411b-8cd6-b52417514cb3_en https://research-and-innovation.ec.europa.eu/document/download/47554adc-dffc-411b-8cd6-b52417514cb3_en .

BEIS . Growing the bioeconomy improving lives and strengthening our economy: a national bioeconomy strategy to 2030 [EB/OL ] . ( 2018-12-05 )[ 2025-06-22 ] . https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1037343/181205_BEIS_Growing_the_Bioeconomy__Web_SP_.pdf https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1037343/181205_BEIS_Growing_the_Bioeconomy__Web_SP_.pdf .

UKRI . Overview of the proposed national engineering biology programme [EB/OL ] . ( 2025-05-10 )[ 2025-06-22 ] . https://www.ukri.org/wp-content/uploads/2021/07/BBSRC-010721-Funding-Opp-DevelopingEngineeringBiologyBreakthroughIdeas-Overview.pdf https://www.ukri.org/wp-content/uploads/2021/07/BBSRC-010721-Funding-Opp-DevelopingEngineeringBiologyBreakthroughIdeas-Overview.pdf .

DSIT . National vision for engineering biology [EB/OL ] . ( 2023-12-05 )[ 2025-06-21 ] . https://assets.publishing.service.gov.uk/media/656de8030f12ef07a53e01ac/national_vision_for_engineering_biology.pdf https://assets.publishing.service.gov.uk/media/656de8030f12ef07a53e01ac/national_vision_for_engineering_biology.pdf .

CSIRO . A national syntheticbiology roadmap:identifying commercial and economicopportunities for Australia [EB/OL ] . ( 2021-08 )[ 2025-06-21 ] . https://www.csiro.au/en/work-with-us/services/consultancy-strategic-advice-services/CSIRO-futures/Future-Industries/Synthetic-Biology-Roadmap https://www.csiro.au/en/work-with-us/services/consultancy-strategic-advice-services/CSIRO-futures/Future-Industries/Synthetic-Biology-Roadmap .

CSIRO . Synthetic biology national progress report [EB/OL ] . ( 2024-02 )[ 2025-06-21 ] . https://www.csiro.au/en/work-with-us/services/consultancy-strategic-advice-services/CSIRO-futures/Future-Industries/Synthetic-Biology-Roadmap https://www.csiro.au/en/work-with-us/services/consultancy-strategic-advice-services/CSIRO-futures/Future-Industries/Synthetic-Biology-Roadmap .

National Engineering Biology Steering Committee . Engineering biology: a platform technology to fuel multi-sector economic recovery and modernize biomanufacturing in Canada [EB/OL ] . ( 2020-11 )[ 2025-05-15 ] . https://www.ontariogenomics.ca/wp-content/uploads/2023/10/WhitePaper_EngineeringBiology_2020.pdf https://www.ontariogenomics.ca/wp-content/uploads/2023/10/WhitePaper_EngineeringBiology_2020.pdf .

Government of Canada . Notice to industry-implementation for health Canada’s new guidance for novel food regulations focused on plant breeding [EB/OL ] . ( 2022-05-18 )[ 2025-06-15 ] . https://inspection.canada.ca/en/food-labels/labelling/2022-05-18 https://inspection.canada.ca/en/food-labels/labelling/2022-05-18 .

Government of Canada . Canadian genomics strategy [EB/OL ] . ( 2025-02-06 )[ 2025-06-10 ] . https://ised-isde.canada.ca/site/genomics/en/canadian-genomics-strategy https://ised-isde.canada.ca/site/genomics/en/canadian-genomics-strategy .

农业农村部科教司 . 加拿大发布修订后的种子法规指南以支持基因编辑种子引入市场 [EB/OL ] . ( 2023-09-25 )[ 2025-06-10 ] . http://www.moa.gov.cn/ztzl/zjyqwgz/ckzl/202309/t20230925_6437177.htm http://www.moa.gov.cn/ztzl/zjyqwgz/ckzl/202309/t20230925_6437177.htm .

Department of Science , Technology and Education , Ministry of Agriculture and Rural Affairs of the People’s Republic of China . Canada issues revised seed regulations guideline to support market introduction of gene-edited seeds [EB/OL ] . ( 2023-09-25 )[ 2025-06-10 ] . http://www.moa.gov.cn/ztzl/zjyqwgz/ckzl/202309/t20230925_6437177.htm http://www.moa.gov.cn/ztzl/zjyqwgz/ckzl/202309/t20230925_6437177.htm .

CFIA . Chapter 2 - Data requirements for single ingredient approval and feed registration [EB/OL ] . ( 2024-05-13 )[ 2025-06-22 ] . https://inspection.canada.ca/en/animal-health/livestock-feeds/regulatory-guidance/rg-1/chapter-2 https://inspection.canada.ca/en/animal-health/livestock-feeds/regulatory-guidance/rg-1/chapter-2 .

科技部 . 科技部关于印发《“十三五”生物技术创新专项规划》的通知 [EB/OL ] . ( 2017-05-10 )[ 2025-06-12 ] . https://most.gov.cn/xxgk/xinxifenlei/fdzdgknr/fgzc/gfxwj/gfxwj2017/201705/t20170517_132857.html https://most.gov.cn/xxgk/xinxifenlei/fdzdgknr/fgzc/gfxwj/gfxwj2017/201705/t20170517_132857.html .

Ministry of Science and Technology of the People’s Republic of China . Issuance notice of the “13th Five-Year” specialized plan for biotechnology innovation by the Ministry of Science and Technology [EB/OL ] . ( 2017-05-10 )[ 2025-06-12 ] . https://most.gov.cn/xxgk/xinxifenlei/fdzdgknr/fgzc/gfxwj/gfxwj2017/201705/t20170517_132857.html https://most.gov.cn/xxgk/xinxifenlei/fdzdgknr/fgzc/gfxwj/gfxwj2017/201705/t20170517_132857.html .

国家发展改革委 . 国家发展改革委关于印发《“十四五”生物经济发展规划》的通知 [EB/OL ] . ( 2021-12-20 )[ 2025-06-12 ] . https://www.gov.cn/zhengce/zhengceku/2022-05/10/content_5689556.htm https://www.gov.cn/zhengce/zhengceku/2022-05/10/content_5689556.htm .

National Development and Reform Commission . Issuance notice of the “14th Five-Year” bioeconomy development plan by the National Development and Reform Commission [EB/OL ] . ( 2021-12-20 )[ 2025-06-12 ] . https://www.gov.cn/zhengce/zhengceku/2022-05/10/content_5689556.htm https://www.gov.cn/zhengce/zhengceku/2022-05/10/content_5689556.htm .

中国技术市场协会 . 合成生物第一部分:农业合成生物技术的创新与应用 [S/OL ] . ( 2024-12-30 )[ 2025-06-12 ] . www.ctm.org.cn/upload/zgjsscxh/file/20250102/1735832708509228.pdf www.ctm.org.cn/upload/zgjsscxh/file/20250102/1735832708509228.pdf .

Technology Market Association of China . Synthetic biology part Ⅰ: innovation and application of agricultural synthetic biology technology [S/OL ] . ( 2024-12-30 )[ 2025-06-12 ] . www.ctm.org.cn/upload/zgjsscxh/file/20250102/1735832708509228.pdf www.ctm.org.cn/upload/zgjsscxh/file/20250102/1735832708509228.pdf .

Benson Hill . Tag: CropOS-Benson Hill expands innovation pipeline with advantaged traits for animal feed, soybean oil, and biofuel segments [EB/OL ] . ( 2024-07-16 )[ 2025-06-21 ] . https://bensonhill.com/tag/cropos/ https://bensonhill.com/tag/cropos/ .

Cibus-The Future of Breeding . Our technology [EB/OL ] . ( 2025-06-21 )[ 2025-06-23 ] . https://www.cibus.com/our-technology.php https://www.cibus.com/our-technology.php .

Olive Oil Times . Gene-edited soybean oil touted as Non-GMO [EB/OL ] . ( 2019-03-12 )[ 2025-06-21 ] . https://www.oliveoiltimes.com/business/gene-edited-soybean-oil-touted-as-non-gmo/67263 https://www.oliveoiltimes.com/business/gene-edited-soybean-oil-touted-as-non-gmo/67263 .

Non-GMO plant transformation [EB/OL ] . [ 2025-06-21 ] . https://www.gflas.com/en/crispr/noneGMO.php https://www.gflas.com/en/crispr/noneGMO.php .

ISAAA Inc . Gene-edited rice may grow in the ocean [EB/OL ] . ( 2023-09-13 )[ 2025-06-21 ] . https://www.isaaa.org/kc/cropbiotechupdate/ged/article/default.asp ID=20412 https://www.isaaa.org/kc/cropbiotechupdate/ged/article/default.aspID=20412 .

Pivot Bio . Pivot Bio PROVEN ® 40 [EB/OL ] . [ 2025-06-21 ] . https://www.pivotbio.com/product-proven40-corn https://www.pivotbio.com/product-proven40-corn .

AgBiome and Genective collaborate to create novel insect-resistant crops [EB/OL ] . ( 2015-07-01 )[ 2025-06-21 ] . https://www.biospace.com/b-agbiome-b-and-b-genective-b-collaborate-to-create-novel-insect-resistant-crops https://www.biospace.com/b-agbiome-b-and-b-genective-b-collaborate-to-create-novel-insect-resistant-crops .

GreenLight Biosciences . RNA Biocontrol & platform [EB/OL ] . [ 2025-06-22 ] . https://www.greenlightbiosciences.com/platform https://www.greenlightbiosciences.com/platform .

Oxitec . Oxitec’s Friendly™ mosquito technology receives U.S. EPA approval for pilot projects in U .S . [EB/OL ] . ( 2020-05-01 )[ 2025-06-22 ] . https://www.oxitec.com/en/news/oxitecs-friendly-mosquito-technology-receives-us-epa-approval-for-pilot-projects-in-us https://www.oxitec.com/en/news/oxitecs-friendly-mosquito-technology-receives-us-epa-approval-for-pilot-projects-in-us .

刘晓 , 毛开云 , 熊霞 , 等 . 合成生物学在未来食品领域的发展趋势与展望 [J ] . 生命科学 , 2025 , 37 ( 1 ): 77 - 85 .

LIU X , MAO K Y , XIONG X , et al . Development trends and prospects in synthetic biology for future food [J ] . Chinese Bulletin of Life Sciences , 2025 , 37 ( 1 ): 77 - 85 .

The Better Meat Co . receives GRAS no questions letter from FDA for Rhiza mycoprotein [EB/OL ] . ( 2024-07-11 )[ 2025-07-23 ] . https://agfundernews.com/the-better-meat-co-receives-gras-no-questions-letter-from-fda-for-rhiza-mycoprotein https://agfundernews.com/the-better-meat-co-receives-gras-no-questions-letter-from-fda-for-rhiza-mycoprotein .

Apeel . Product Information [EB/OL ] . [ 2025-06-22 ] . https://www.apeel.com/product-information https://www.apeel.com/product-information .

Nature’s Fynd . Frequently asked questions—What is Fy™? [EB/OL ] . [ 2025-06-22 ] . https://www.naturesfynd.com/faq#collapsible-panel-152400 https://www.naturesfynd.com/faq#collapsible-panel-152400 .

Agrivida . What’s in it? [EB/OL ] . [ 2025-06-22 ] . https://agrivida.com/ https://agrivida.com/ .

Calysta . FeedKind ® is a family of feed ingredients for use across aquaculture and livestock species [EB/OL ] . [ 2025-06-22 ] . https://calysta.com/fish-and-livestock/ https://calysta.com/fish-and-livestock/ .

Qi Biodesign . Qi-biodesign has been granted a safety certificate for gene-edited high-yield wheat resistant to powdery mildew [EB/OL ] . [ 2025-06-22 ] . http://www.qi-biodesign.com/#/newsDetail id=17 http://www.qi-biodesign.com/#/newsDetailid=17 .

Qi Biodesign . Qi-biodesign’s high oleic acid soybeans have been granted an exemption by the USDA [EB/OL ] . [ 2025-06-22 ] . http://www.qi-biodesign.com/#/newsDetail id=16 http://www.qi-biodesign.com/#/newsDetailid=16 .

隆平高科 . 科研体系 [EB/OL ] . [ 2025-06-22 ] . https://www.lpht.com.cn/leader.html#page3 https://www.lpht.com.cn/leader.html#page3 .

Yuan Long Ping High-Tech Agriculture Co. , Ltd . Scientific research system [EB/OL ] . [ 2025-06-22 ] . https://www.lpht.com.cn/leader.html#page3 https://www.lpht.com.cn/leader.html#page3 .

舜丰生物 . 成果介绍 [EB/OL ] . [ 2025-06-22 ] . http://bellagen.cn/index.php?catid=39 http://bellagen.cn/index.php?catid=39 .

BellaGen . Achievements introduction [EB/OL ] . [ 2025-06-22 ] . http://bellagen.cn/index.php?catid=39 http://bellagen.cn/index.php?catid=39 .

蓝晶微生物与大北农集团签署合作 [EB/OL ] . ( 2024-08-06 )[ 2025-06-22 ] . https://zshq.zuiyouliao.com/zixun/detail-ac28cdfd19ad4800ba12a37c813cb7ea.html https://zshq.zuiyouliao.com/zixun/detail-ac28cdfd19ad4800ba12a37c813cb7ea.html .

Bluepha and Dabeinong Group signed cooperation agreement [EB/OL ] . ( 2024-08-06 )[ 2025-06-22 ] . https://zshq.zuiyouliao.com/zixun/detail-ac28cdfd19ad4800ba12a37c813cb7ea.html https://zshq.zuiyouliao.com/zixun/detail-ac28cdfd19ad4800ba12a37c813cb7ea.html .

中国农业科学院深圳农业基因组研究所 . 企业孵化 [EB/OL ] . [ 2025-06-22 ] . https://agis.caas.cn/cyfz/qyfh/index.htm https://agis.caas.cn/cyfz/qyfh/index.htm .

Shenzhen Agricultural Genomics Institute, Chinese Academy of Agricultural Sciences . Enterprise incubation [EB/OL ] . [ 2025-06-22 ] . https://agis.caas.cn/cyfz/qyfh/index.htm https://agis.caas.cn/cyfz/qyfh/index.htm .

慕恩生物 . 生物制剂的先行者 - 植物微生物组 [EB/OL ] . [ 2025-06-22 ] . https://www.moonbio.com/bioAg https://www.moonbio.com/bioAg .

MoonBiotech . Pioneer in biological agents - plant microbiome [EB/OL ] . [ 2025-06-22 ] . https://www.moonbio.com/bioAg https://www.moonbio.com/bioAg .

昌进生物 . 人类需要优质蛋白,只能依托于传统的动、植物吗? [EB/OL ] . [ 2025-06-22 ] . http://chgbio.com/ http://chgbio.com/ .

Changing Bio . Does humanity need high-quality protein only from traditional animal and plant sources? [EB/OL ] . [ 2025-06-22 ] . http://chgbio.com/ http://chgbio.com/ .

芝诺科技 . 核心研究 [EB/OL ] . [ 2025-06-22 ] . http://www.zenobiotech.cn/sy http://www.zenobiotech.cn/sy .

Beijing Zhinuo Technology Development Co. , Ltd . Core research [EB/OL ] . [ 2025-06-22 ] . http://www.zenobiotech.cn/sy http://www.zenobiotech.cn/sy .

首钢朗泽 . 技术竞争优势 [N/OL ] . [ 2025-08-22 ] . http://www.beijingreview.com.cn/caijing/hyzx/202507/t20250716_800408499.html http://www.beijingreview.com.cn/caijing/hyzx/202507/t20250716_800408499.html .

Shougang LangzeTech . Technological competitive advantages [N/OL ] . [ 2025-08-22 ] . http://www.beijingreview.com.cn/caijing/hyzx/202507/t20250716_800408499.html http://www.beijingreview.com.cn/caijing/hyzx/202507/t20250716_800408499.html .

引航生物 . 25 -羟基维生素D3 聚焦原料竞争力 [EB/OL ] . [ 2025-06-22 ] . https://www.leadsynbio.com/qjwssd3.html https://www.leadsynbio.com/qjwssd3.html .

Leadsynbio . 25-Hydroxy vitamin D 3 : emphasizing raw material competitiveness [EB/OL ] . [ 2025-06-22 ] . https://www.leadsynbio.com/qjwssd3.html https://www.leadsynbio.com/qjwssd3.html .

德默特 . 实现海洋硅藻多管线联产 [EB/OL ] . [ 2025-06-22 ] . http://dmtbiotech.com/info/8.html http://dmtbiotech.com/info/8.html .

DMT Biotech . Achieving multi-pipeline co-production of marine diatoms [EB/OL ] . [ 2025-06-22 ] . http://dmtbiotech.com/info/8.html http://dmtbiotech.com/info/8.html .

百斯杰 . 动物营养与健康 [EB/OL ] . [ 2025-06-22 ] . https://www.bestzyme.com.cn/Home/application typeId=3 https://www.bestzyme.com.cn/Home/applicationtypeId=3 .

Bestzyme . Animal nutrition and health [EB/OL ] . [ 2025-06-22 ] . https://www.bestzyme.com.cn/Home/application?typeId=3 https://www.bestzyme.com.cn/Home/application?typeId=3 .

利民控股 . 合作开发噬菌体生物农药 ——合成生物战略落地的又一举措 [EB/OL ] . ( 2024-10-21 )[ 2025-06-22 ] . https://www.chinalimin.com/new_detail/id/2169.html https://www.chinalimin.com/new_detail/id/2169.html .

Limin Group . Collaborative development of bacteriophage biopesticides—another step in implementing the synthetic biology strategy [EB/OL ] . ( 2024-10-21 )[ 2025-06-22 ] . https://www.chinalimin.com/new_detail/id/2169.html https://www.chinalimin.com/new_detail/id/2169.html .

富邦科技 . 产品展示-微生物菌剂 [EB/OL ] . [ 2025-06-22 ] . https://www.forbon.com/Product/20.html https://www.forbon.com/Product/20.html .

Forbon Technology . Product showcase-microbial inoculants [EB/OL ] . [ 2025-06-22 ] . https://www.forbon.com/Product/20.html https://www.forbon.com/Product/20.html .

富邦科技 . 产品展示-作物营养 [EB/OL ] . [ 2025-06-22 ] . https://www.forbon.com/Product/6.html#c_static_001-1705631908362 https://www.forbon.com/Product/6.html#c_static_001-1705631908362 .

Forbon Technology . Product showcase-crop nutrition [EB/OL ] . [ 2025-06-22 ] . https://www.forbon.com/Product/6.html#c_static_001-1705631908362 https://www.forbon.com/Product/6.html#c_static_001-1705631908362 .

微构工场 . PHAbrary精准定制、AI协同的应用解决方案 [EB/OL ] . [ 2025-06-22 ] . https://www.phabuilder.com/PHAbrary_Compound#page106 https://www.phabuilder.com/PHAbrary_Compound#page106 .

Phabuilder . PHAbrary: precisely customized and AI-coordinated application solutions [EB/OL ] . [ 2025-06-22 ] . https://www.phabuilder.com/PHAbrary_Compound#page106 https://www.phabuilder.com/PHAbrary_Compound#page106 .

蔚蓝生物 . 饲料酶 [EB/OL ] . [ 2025-06-22 ] . http://vlandgroup.com/about/38.html http://vlandgroup.com/about/38.html .

Qingdao Vland Biotech INC . Feed enzymes [EB/OL ] . [ 2025-06-22 ] . http://vlandgroup.com/about/38.html http://vlandgroup.com/about/38.html .

播恩集团 . 向微生物要蛋白:播恩两大生物饲料新品齐发,力求降本、增效出众 [EB/OL ] . ( 2022-04-11 )[ 2025-06-22 ] . http://www.bo-en.com/?p=2901 http://www.bo-en.com/?p=2901 .

Boen Group . Obtain protein from microorganisms: Boen launches two new biofeed products, aiming for significant cost reduction and efficiency improvement [EB/OL ] . ( 2022-04-11 )[ 2025-06-22 ] . http://www.bo-en.com/?p=2901 http://www.bo-en.com/?p=2901 .

绿氮生物 . DME技术与产品 [EB/OL ] . [ 2025-06-22 ] . https://www.agreenbio.com/DME-TP/ https://www.agreenbio.com/DME-TP/ .

AGreenBio . DME technology and products [EB/OL ] . [ 2025-06-22 ] . https://www.agreenbio.com/DME-TP/ https://www.agreenbio.com/DME-TP/ .

元一生物 . 元一生物与大北农集团签署战略合作协议 [EB/OL ] . ( 2023-12-07 )[ 2025-06-22 ] . https://www.yuanyibio.com/news/42.html https://www.yuanyibio.com/news/42.html

Ueny . Ueny and Dabeinong Group signed Strategic Cooperation Agreement [EB/OL ] . ( 2023-12-07 )[ 2025-06-22 ] . https://www.yuanyibio.com/news/42.html https://www.yuanyibio.com/news/42.html

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