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1.天津科技大学生物工程学院,天津 300457
2.天津科技大学工业发酵微生物教育部重点实验室,天津 300457
Received:01 August 2024,
Revised:2024-10-11,
Published:30 April 2025
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伊进行, 唐宇琳, 李春雨, 吴鹤云, 马倩, 谢希贤. 氨基酸衍生物在化妆品中的应用及其生物合成研究进展[J]. 合成生物学, 2025, 6(2): 254-289
YI Jinhang, TANG Yulin, LI Chunyu, WU Heyun, MA Qian, XIE Xixian. Applications and advances in the research of biosynthesis of amino acid derivatives as key ingredients in cosmetics[J]. Synthetic Biology Journal, 2025, 6(2): 254-289
伊进行, 唐宇琳, 李春雨, 吴鹤云, 马倩, 谢希贤. 氨基酸衍生物在化妆品中的应用及其生物合成研究进展[J]. 合成生物学, 2025, 6(2): 254-289 DOI: 10.12211/2096-8280.2024-060.
YI Jinhang, TANG Yulin, LI Chunyu, WU Heyun, MA Qian, XIE Xixian. Applications and advances in the research of biosynthesis of amino acid derivatives as key ingredients in cosmetics[J]. Synthetic Biology Journal, 2025, 6(2): 254-289 DOI: 10.12211/2096-8280.2024-060.
随着合成生物学的快速发展,氨基酸衍生物作为一类重要的化妆品原料,其生产方式正发生历史性革新。传统生产方法存在生产成本高、环境负担重、产品稳定性差等问题。运用合成生物技术设计构建微生物细胞工厂,不仅能有效提升目标产品生产效率、降低成本,还能实现绿色生物制造,满足市场对天然、安全、功能性强化妆品原料的供应需求。本文介绍了氨基酸衍生物在化妆品中的应用,并对其生物合成策略进行了总结,从酶转化和微生物发酵两种主要的生物合成工艺入手,探讨了酶工程、理性代谢工程以及非理性筛选等策略在化妆品原料氨基酸衍生物细胞工厂构建中的应用,并进一步对化妆品原料氨基酸衍生物的生物合成研究进展与发展趋势进行了系统综述。在人工智能等前沿技术的赋能助力下,合成生物技术必将进一步推动化妆品原料高效绿色生物制造的革新进程。
The development of synthetic biology has witnessed rapid advancements
which have significantly promoted production innovations in multiple sectors. In the cosmetics industry
the production methods of amino acid derivatives
which are a kind of pivotal raw materials in cosmetics
are experiencing groundbreaking innovations. The traditional methods for the production of amino acid derivatives have the problem of high cost
and usually generate environmental risk. Besides
the production stabilities of the target products are often unsatisfactory. The application of synthetic biology technology in the design and engineering of microbial cell factories for the bioproduction of amino acid derivatives
can greatly enhance the production efficiency and reduce the production costs of the target products. This innovative approach not only enhances the development of green biomanufacturing
but also benefits the demand of market for natural
safe
and functional cosmetic ingredients. In this review
an overall introduction to the utilization of amino acid derivatives in cosmetics industry is first provided. Subsequently
the strategies for the construction of high-producing strains for the production of amino acid derivatives are comprehensively summarized
which are basically categorized into two groups: enzyme conversion and microbial fermentation. The application of enzyme engineering
rational metabolic engineering
and random screening in the construction of microbial cell factories for the production of amino acid derivatives are systematically introduced. Moreover
the current research advancements and trends in the biosynthesis of amino acid derivatives as cosmetic raw materials are outlined. With the support of the cutting-edge technologies such as artificial intelligence
synthetic biology will further promote the production innovation process
enabling efficient and eco-friendly biomanufacturing of a wider array of cosmetic raw materials. This ongoing evolution holds immense promise for the cosmetics industry
promising a future with sustainable and innovative products.
2
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