Overview on platform for synthetic biology research at Shenzhen

ZHANG Ting; LENG Mengtian; JIN Fan; YUAN Hai

doi:10.12211/2096-8280.2021-077

您当前的位置：

首页 >

文章列表页 >

Overview on platform for synthetic biology research at Shenzhen

Invited Review | 更新时间：2025-03-20

- Overview on platform for synthetic biology research at Shenzhen
- Synthetic Biology Journal Vol. 3, Issue 1, Pages: 184-194(2022)
- 作者机构：
  
  1.中国科学院深圳先进技术研究院，深圳合成生物学创新研究院，广东深圳 518055
  2.中国科学院广州先进技术研究所，广东广州 511400
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2021-077
  CLC： Q819
- Received：23 July 2021，
  
  Revised：2021-12-06，
  
  Published：28 February 2022
- 稿件说明：
移动端阅览
张亭，冷梦甜，金帆，袁海. 合成生物研究重大科技基础设施概述［J］. 合成生物学， 2022， 3（1）： 184-194

ZHANG Ting， LENG Mengtian， JIN Fan， YUAN Hai. Overview on platform for synthetic biology research at Shenzhen［J］. Synthetic Biology Journal， 2022， 3（1）： 184-194
张亭，冷梦甜，金帆，袁海. 合成生物研究重大科技基础设施概述［J］. 合成生物学， 2022， 3（1）： 184-194 DOI： 10.12211/2096-8280.2021-077.

ZHANG Ting， LENG Mengtian， JIN Fan， YUAN Hai. Overview on platform for synthetic biology research at Shenzhen［J］. Synthetic Biology Journal， 2022， 3（1）： 184-194 DOI： 10.12211/2096-8280.2021-077.

摘要

合成生物学研究中，海量的工程化试错实验远远超出传统的劳动密集型研究范式的能力范畴，故建立一个可以实现生命体工程化大批量合成的合成生物学研究平台迫在眉睫。然而目前国内外已建成的工程化平台只能基于少数孤立设备或功能岛实现部分流程，不能满足合成生物学全生命周期的研究需求。基于此背景，在国家、省市相关部门的大力支持下，由中国科学院深圳先进技术研究院牵头建设的“合成生物研究重大科技基础设施”，目前已完成全部立项程序，进入全面实施建设阶段，预计于2023年开展试运营和验收工作。本文将从建设背景、过程、内容、目标和特色等方面对合成生物研究重大科技基础设施进行介绍。设施工程一期将重点搭建“设计学习”、“合成测试”和“用户检测”三大平台，二期拟建设医学转化平台。合成生物大设施主要围绕自动化合成生物技术，以合成生物学基础研究为理论基础，把自动化工业发展过程中的智能制造、智能工厂理念引入到合成生物学研究中，实现生命体工程化大批量合成。通过建立基于信息管理系统的智能生产单元，快速、低成本、多循环地完成“设计-构建-测试-学习”的闭环，实现理性可预测的设计合成，达成合成生命体的远程定制、异地设计和规模经济生产等目标。同时将信息技术与生物技术交叉融合，发展出适用于自动化、高通量设备平台的标准化实验方法、算法和流程，以期推动合成生物研究过程和工作流程的标准化，进而推动我国合成生物研究水平的提升，成为行业标杆，领跑国际。此外，合成生物大设施还将催动基础研究的原创突破及学科之间的交叉融合，助力生命科学研究实现跨越式发展。

Abstract

With the rapid development of synthetic biology

traditional labor-intensive research paradigm no longer satisfies the demand from increased numbers for trial-and-error experiments and processing and analysis of mega data. With the support from national

provincial and municipal governments

platform for synthetic biology research

established by Shenzhen Institute of Advanced Technology

Chinese Academy of Sciences is now ready for operation

and expected to put into running in 2023. This report presents a brief introduction to The Major Scientific and Technological Infrastructure for Synthetic Biology Research. The first phase development for the Infrastructure includes three platforms: Design and Learning

Synthesis

and User Testing

and the second phase is for the medical transformation platform. The Infrastructure mainly focus on automated synthetic biotechnology

and introduces the concepts of intelligent manufacturing into synthetic biology research for high-throughput synthesis of living organisms. Through the establishment of such an intelligent production unit based on the information management system

the closed loop of “design-build-test-learn (DBTL)” can be implemented more efficiently with high-throughput and low-cost

which can realize rational and predictable design and synthesis

and also achieve remote design and economical production of synthetic living organisms at large scale. In addition

the platform integrates information technology (IT) and biological technology (BT) through information interconnection and internet of thing (IoT) devices for being fully automated and intelligent to conduct standardized tests

algorithms

processes and other workflows

which ultimately helps to inspire breakthroughs in basic research and interdisciplinary integration for technological innovations.

关键词

Keywords

references

崔金明 , 张炳照 , 马迎飞 , 等 . 合成生物学研究的工程化平台 [J ] . 中国科学院院刊 , 2018 , 33 ( 11 ): 1249 - 1257 .

CUI J M , ZHANG B Z , MA Y F , et al . Engineering platforms for synthetic biology research [J ] . Bulletin of Chinese Academy of Sciences , 2018 , 33 ( 11 ): 1249 - 1257 .

唐婷 , 付立豪 , 郭二鹏 , 等 . 自动化合成生物技术与工程化设施平台 [J ] . 科学通报 , 2021 ( 3 ): 300 - 309 .

TANG T , FU L H , GUO E P , et al . Automation in synthetic biology using biological foundries [J ] . Chinese Science Bulletin , 2021 ( 3 ): 300 - 309 .

CLARKE L J , KITNEY R I . Synthetic biology in the UK—an outline of plans and progress [J ] . Synthetic and Systems Biotechnology , 2016 , 1 ( 4 ): 243 - 257 .

晁然 , 原永波 , 赵惠民 . 构建合成生物学制造厂 [J ] . 中国科学:生命科学 , 2015 , 45 ( 10 ): 976 - 984 .

CHAO R , YUAN Y B , ZHAO H M . Factory construction of synthetic biology [J ] . Scientia Sinica (Vitae) , 2015 , 45 ( 10 ): 976 - 984 .

潘勋 , 冯倩倩 , 王宏伟 . 持续建设科研条件平台助力生命学科跨越式发展 [J ] . 实验技术与管理 , 2021 , 38 ( 4 ): 1 - 6 .

PAN X , FENG Q Q , WANG H W . Continuous construction of scientific research support platform to promote great-leap forward development of life sciences [J ] . Experimental Technology and Management , 2021 , 38 ( 4 ): 1 - 6 .

HILLSON N , CADDICK M , CAI Y Z , et al . Building a global alliance of biofoundries [J ] . Nature Communications , 2019 , 10 : 2040 .

程晓舫 , 唐磊 , 夏依林 . 大科学装置共建共享及其对区域一体化的影响——以长三角为例 [J ] . 科技管理研究 , 2020 , 40 ( 22 ): 26 - 31 .

CHENG X F , TANG L , XIA Y L . The co-construction and sharing of large-scale scientific facilities and its impact on regional integration: taking the Yangtze River Delta as an example [J ] . Science and Technology Management Research , 2020 , 40 ( 22 ): 26 - 31 .

唐婷 , 付立豪 , 郭二鹏 , 等 . 自动化合成生物技术与工程化设施平台 [J ] . 科学通报 , 2021 , 66 ( 3 ): 300 - 309 .

TANG T , FU L H , GUO E P , et al . Automation in synthetic biology using biological foundries [J ] . Chinese Science Bulletin , 2021 , 66 ( 3 ): 300 - 309 .

胡如云 , 张嵩亚 , 蒙海林 , 等 . 面向合成生物学的机器学习方法及应用 [J ] . 科学通报 , 2021 , 66 ( 3 ): 284 - 299 .

HU R Y , ZHANG S Y , MENG H L , et al . Machine learning for synthetic biology: Methods and applications [J ] . Chinese Science Bulletin , 2021 , 66 ( 3 ): 284 - 299 .

Global BioFoundry Meeting Workshop Report [R ] . London, UK : Imperial College , 2018 .

张建志 , 付立豪 , 唐婷 , 等 . 基于合成生物学策略的酶蛋白元件规模化挖掘 [J ] . 合成生物学 , 2020 , 1 ( 3 ): 319 - 336 .

ZHANG J Z , FU L H , TANG T , et al . Scalable mining of proteins for biocatalysis via synthetic biology [J ] . Synthetic Biology Journal , 2020 , 1 ( 3 ): 319 - 336 .

杜全生 , 洪伟 , 祖岩 . 2010—2019年国家自然科学基金资助合成生物学领域情况 [J ] . 合成生物学 , 2020 , 1 ( 3 ): 385 - 394 .

DU Q S , HONG W , ZU Y . Grant and funding for synthetic biology at NSFC from 2010 to 2019 [J ] . Synthetic Biology Journal , 2020 , 1 ( 3 ): 385 - 394 .

丁明珠 , 李炳志 , 王颖 , 等 . 合成生物学重要研究方向进展 [J ] . 合成生物学 , 2020 , 1 ( 1 ): 7 - 28 .

DING M Z , LI B Z , WANG Y , et al . Significant research progress in synthetic biology [J ] . Synthetic Biology Journal , 2020 , 1 ( 1 ): 7 - 28 .

刘晓 , 王跃 , 毛开云 , 等 . 生物技术与信息技术的融合发展 [J ] . 中国科学院院刊 , 2020 , 35 ( 1 ): 34 - 42 .

LIU X , WANG Y , MAO K Y , et al . Converge development of biotechnology and information technology [J ] . Bulletin of Chinese Academy of Sciences , 2020 , 35 ( 1 ): 34 - 42 .

MORRELL W C , BIRKEL G W , FORRER M , et al . The experiment data depot: a web-based software tool for biological experimental data storage, sharing, and visualization [J ] . ACS Synthetic Biology , 2017 , 6 ( 12 ): 2248 - 2259 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Synthetic biology-powered cell membrane-derived nanoparticles for precision theranostics

Synthetic biology-driven advances in artificial blood research

Applications of synthetic biology in medical diagnosis and treatment： technological breakthroughs and ethical issues

Biosynthetic strategies of medical polyhydroxyalkanoate （PHA） and their new developments for human health

Related Author

Ting ZHANG

Mengtian LENG

Fan JIN

Hai YUAN

HUANG Yang

LI Yiye

NIE Guangjun

HUANG Ruping

Related Institution

Shenzhen Institute of Synthetic Biology， Shenzhen Institutes of Advanced Technology， Chinese Academy of Sciences

Guangzhou Institute of Advanced Technology， Chinese Academy of Sciences

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety， CAS Center for Excellence in Nanoscience， National Center for Nanoscience and Technology of China

School of Nanoscience and Engineering， University of Chinese Academy of Sciences

College of Materials Science and Opto-Electronic Technology， University of Chinese Academy of Sciences

⁰