DNA data storage： preservation approach and data encryption

ZHOU Tingyao; LUO Yuan; JIANG Xingyu

doi:10.12211/2096-8280.2020-084

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DNA data storage： preservation approach and data encryption

Invited Review | 更新时间：2025-03-20

- DNA data storage： preservation approach and data encryption
- Synthetic Biology Journal Vol. 2, Issue 3, Pages: 371-383(2021)
- 作者机构：
  
  南方科技大学生物医学工程系，广东深圳 518055
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2020-084
  CLC： R 318;Q819
- Received：01 December 2020，
  
  Revised：2021-03-03，
  
  Published：30 June 2021
- 稿件说明：
移动端阅览
周廷尧，罗源，蒋兴宇. DNA数据存储：保存策略与数据加密［J］. 合成生物学， 2021， 2（3）： 371-383

ZHOU Tingyao， LUO Yuan， JIANG Xingyu. DNA data storage： preservation approach and data encryption［J］. Synthetic Biology Journal， 2021， 2（3）： 371-383
周廷尧，罗源，蒋兴宇. DNA数据存储：保存策略与数据加密［J］. 合成生物学， 2021， 2（3）： 371-383 DOI： 10.12211/2096-8280.2020-084.

ZHOU Tingyao， LUO Yuan， JIANG Xingyu. DNA data storage： preservation approach and data encryption［J］. Synthetic Biology Journal， 2021， 2（3）： 371-383 DOI： 10.12211/2096-8280.2020-084.

摘要

随着信息技术和互联网应用的不断升级，人类社会进入数据爆炸式增长的时代。为缓解海量数据与存储技术不足之间的矛盾，人们开始寻求新一代的存储方式。DNA作为一种新兴的数据存储媒介，具有巨大的发展潜力，其优势包括超高的数据存储密度（理论可达现有技术10

倍）、能耗低以及寿命长（理论可达数十万年）。这些特点可有效克服传统存储介质如硬盘、光盘和固体闪存等的不足。本文以DNA数据存储为主线，阐述了DNA数据存储的基本理论和工作流程，重点介绍了DNA保存的方法与策略研究进展，简要总结了信息安全与数据加密的最新研究成果，最后讨论DNA数据存储现阶段面临的主要挑战

及发展趋势，特别是，DNA数据存储效率提升、存储读取高度集成自动化以及数据加密新策略等方面将是DNA数据存储的重要研究方向。相信随着合成生物学的不断发展，DNA数据存储将成为未来最具应用潜力的新型存储方式。

Abstract

With the rapid development of information technology and the Internet

human society has entered a new big data era. According to the global DataSphere by international data corporation (IDC)

more than 5.9×10

bytes of data will be created and consumed within 2020

and a 26% data growth rate will be sustained through 2024. These data have outpaced the existing storage formats' capability

including magnetic

optical and electronic media. To alleviate the growing gap between explosive data production and current storage capability

it is highly desirable to explore novel solutions for data storage. As an emerging data storage medium

DNA offers substantial advantages over conventional media

including ultra-high data storage density (theoretically 10

times higher than existing technology)

low energy consumption

and long lifetime (up to several hundred thousand years in theory)

and has great potential applications in the future. In this review

we present the basic theory and the workflow of DNA data storage

including encode

write

store and encrypt

random access

read

and decode. We also discuss the research progress on data retention strategies

highlighting

in vitro

and

in vivo

DNA storage. In comparison with

in vivo

strategy

in vitro

storage may have the greatest potential for applications in consideration of cost

durability

and scalability. We briefly summarize the latest research about information security and data encryption using DNA. Finally

we discuss the current challenges and emerging trends in DNA data storage. The cost of DNA synthesis and sequencing largely restricts the rapid development of DNA data storage. Further unresolved questions include efficient preservation and feasible random access. To solve the challenges

imp

roving the efficiency of DNA data storage

storage

and reading automation and new strategies for data encryption will be important research directions for DNA data storage. It is believed that with the continuous development of synthetic biology

DNA data storage will become the most promising form for information storage in the future.

关键词

Keywords

references

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