Advances in synthetic biomanufacturing

ZHANG Yuanyuan; ZENG Yan; WANG Qinhong

doi:10.12211/2096-8280.2020-052

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Advances in synthetic biomanufacturing

Invited Review | 更新时间：2025-03-20

- Advances in synthetic biomanufacturing
  封面论文
- Synthetic Biology Journal Vol. 2, Issue 2, Pages: 145-160(2021)
- 作者机构：
  
  1.中国科学院天津工业生物技术研究所，中国科学院系统微生物工程重点实验室，天津 300308
  2.中国科学院科技促进发展局，北京 100864
- 作者简介：
- 基金信息：
- DOI：10.12211/2096-8280.2020-052
  CLC： Q81
- Received：07 June 2020，
  
  Revised：2021-02-04，
  
  Published：30 April 2021
- 稿件说明：
移动端阅览
张媛媛, 曾艳, 王钦宏. 合成生物制造进展[J]. 合成生物学, 2021, 2(2): 145-160

ZHANG Yuanyuan, ZENG Yan, WANG Qinhong. Advances in synthetic biomanufacturing[J]. Synthetic Biology Journal, 2021, 2(2): 145-160
张媛媛, 曾艳, 王钦宏. 合成生物制造进展[J]. 合成生物学, 2021, 2(2): 145-160 DOI： 10.12211/2096-8280.2020-052.

ZHANG Yuanyuan, ZENG Yan, WANG Qinhong. Advances in synthetic biomanufacturing[J]. Synthetic Biology Journal, 2021, 2(2): 145-160 DOI： 10.12211/2096-8280.2020-052.

摘要

合成生物制造是以合成生物为工具进行物质加工与合成的生产方式，有望彻底变革未来医药、化工、食品、能源、材料、农业等传统模式，触发新的产业变革，引领新的产业模式和经济形态，重塑碳基物质文明。合成生物制造具有清洁、高效、可再生等特点，能够减少工业经济对生态环境的影响。本文综述了近年来合成生物制造在大宗发酵产品、精细与医药化学品、可再生化学品与聚合材料、天然产物、未来农产品以及一碳原料利用方面的重要进展，对各领域代表性重大产品的技术进展及产业应用状况与潜力进行了探讨。未来，随着合成生物学发展，以及与人工智能、大数据等新技术的融合，通过合成生物制造可以获得更多的生物基产品，促进生物经济形成，更好地服务于人类社会的可持续发展。

Abstract

Synthetic biomanufacturing is a paradigm for material processing and synthesis via synthetic biology. It is expected to completely transform the traditional production mode for medicines

chemicals

food

energy

materials and agriculture in the future

trigger new industrial revolution

lead to new economic growth and reshape carbon-based civilization. In particular

the COVID-19 global spread that has accelerated the reshaping process of the world's economic and social development. In the foreseeable future

human life and production patterns will undergo profound changes in medicines and healthcare

food and agriculture

energy and materials

etc.

during which demands for new technologies will promote evolution in the field of biotechnology

and the biomanufacturing industry in the post COVID-19 era is facing unprecedented opportunities for revitalization and new challenges. According to the analysis of the research report from the Ministry of Economy

Trade and Industry of Japan

engineered biological cells and their combination with information

artificial intelligence technologies will become the main driving force for the "post-fourth industrial revolution".Synthetic biomanufacturing has the characteristics of cleanliness

efficiency and renewableness that can reduce the impact of industrial economy on the ecological environment. Here

in this review

we summarize the progress of synthetic biomanufacturing with respect to bulk fermentation products

fine and pharmaceutical chemicals

renewable chemic

als and bio-based polymeric materials

natural products

foods and the utilization of C

raw materials. The technological progress

status and potential of industrial applications of many important bio-based products

via

synthetic biomanufacturing are analyzed and discussed. The development of synthetic biomanufacturing shows great potentials for building up the ecological route of industrial economy and addressing current issues of economic sustainability in terms of limited substrate

high cost

and poor viability

and to form whole new industry chain with sustainable growth. In the future

with the development of synthetic biology

and the integration of new technologies such as artificial intelligence and big data

more and more bio-based products can be produced via synthetic biomanufacturing. The formation of bioeconomy can be promoted

and the sustainable development of human society will be better served.

关键词

Keywords

references

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